Bisby et al. (2022) investigated whether internet-delivered pain management programs can reduce psychological distress in patients with chronic pain, specifically exploring the relationships between anxiety, depression, pain intensity, and disability.
Boersma et al. (2019) conducted a randomized controlled trial evaluating the efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients who also suffer from comorbid anxiety and depression.
The study by Boersma et al. (2019) in Sweden evaluated the efficacy of an online CBT intervention versus a hybrid intervention for patients with chronic musculoskeletal pain, depression, and anxiety.
Psychological distress can negatively impact adherence to pain management interventions, leading to decreased engagement in self-care activities and treatment plan compliance among patients with depression or anxiety, which ultimately affects treatment outcomes.
In a 2016 randomized controlled trial conducted in Australia, Migliorini et al. studied patients with chronic spinal cord injury and depression or anxiety, comparing a treatment group receiving CBT (n=34) against a waitlist control group (n=25).
The study by Ólason et al. (2018) in Iceland evaluated the efficacy of CBT combined with treatment as usual (TAU) versus TAU alone for patients with chronic pain and depression or anxiety.
The systematic review search strategy utilized a Boolean search string combining three categories: (1) pain-related terms (e.g., chronic pain, neuropathic pain, fibromyalgia), (2) psychological distress terms (e.g., depression, anxiety, stress, emotional regulation), and (3) intervention terms (e.g., psychotherapy, cognitive behavioral therapy, mindfulness, acceptance and commitment therapy).
In a study by Torrijos-Zarcero et al. (2021) in Spain, patients with chronic pain, depression, and anxiety were treated in a randomized controlled trial comparing Mindfulness-Based Stress Reduction (MSC) (n=62) against Cognitive Behavioral Therapy (CBT) (n=61) using weekly face-to-face sessions.
Cognitive behavioral therapy (CBT) interventions for anxiety were evaluated across 6 studies, involving 270 participants in the intervention group and 255 in the control group, with 83% of studies showing positive results at post-treatment and 75% at follow-up.
Drapeau et al. (2012) define psychological distress as a "state of emotional suffering characterized by the undifferentiated combinations of symptoms of depression (e.g., lost interest, sadness, hopelessness) and anxiety (e.g., restlessness, feeling tense) which are sometimes accompanied by somatic symptoms (e.g., insomnia, headaches, lack of energy)."
A single study (Torrijos-Zarcero et al., 2021) indicated significant differences in anxiety, pain interference, pain acceptance, pain catastrophizing, and self-compassion at post-treatment in favor of Mindfulness-Based Interventions (MBI) compared to Cognitive Behavioral Therapy (CBT).
Different forms of Cognitive Behavioral Therapy (CBT) are frequently applied to chronic pain and related conditions like anxiety and depression, and appear effective when explored independently, according to research by Churchill et al. (2013), Cuijpers et al. (2013), Buhrman et al. (2016), and Pasarelu et al. (2017).
Snyder and Handrup (2018) discuss the challenges involved in the treatment of patients with comorbid chronic pain, depression, and anxiety.
Behavioral activation therapy for depression (BATD) for anxiety was evaluated in 1 study, involving 78 participants in the intervention group and 78 in the control group, with 0% of studies showing positive results at post-treatment or follow-up.
Mindfulness-based interventions (MBI) for anxiety were evaluated in 1 study, involving 26 participants in the intervention group and 14 in the control group, with 0% of studies showing positive results at post-treatment or follow-up.
Rayner et al. (2016) demonstrate that individuals with chronic pain are more likely to experience psychological distress (such as anxiety and depression), and individuals with psychological distress are more likely to report chronic pain.
Traditional cognitive behavioral therapy (CBT) improves depression, anxiety, and quality of life in patients with comorbid chronic pain and clinically relevant psychological distress, but does not improve pain intensity or pain catastrophizing.
Ólason et al. (2018) conducted a randomized controlled trial with a 3-year follow-up on the use of cognitive behavioral therapy for depression and anxiety within an interdisciplinary rehabilitation program for chronic pain, published in the International Journal of Behavioral Medicine.
Buhrman et al. (2015) studied the use of individualized guided internet-delivered cognitive behavior therapy for patients suffering from chronic pain with comorbid depression and anxiety.
The systematic review explored pain-related variables (pain interference, pain intensity, pain acceptance, pain catastrophizing, and pain self-efficacy), emotional functioning (depression, anxiety, and stress), health-related quality of life, behavioral activation, and psychological flexibility.
CBT-based interventions were more effective than control groups in improving depression, anxiety, and quality of life at both post-treatment and follow-up, but not in improving pain intensity, according to the systematic review.
Pasarelu et al. (2017) performed a systematic review and meta-analysis of randomized controlled trials regarding internet-delivered transdiagnostic and tailored cognitive behavioral therapy for anxiety and depression, published in Cognitive Behaviour Therapy.
The CBT intervention in the Ólason et al. (2018) study consisted of 12 sessions of 45 minutes each, delivered by a multidisciplinary team including psychologists, nurses, occupational therapists, and social workers, and experienced a 34% dropout rate.
The systematic review excluded adults diagnosed with psychiatric disorders other than depression and/or anxiety, those with other clinically relevant psychiatric symptoms, substance dependence, or neurodegenerative disorders.
White, Linardon, Stone, Holmes-Truscott, Olive, Mikocka-Walus, et al. (2022) conducted a systematic review and meta-analysis of randomized controlled trials titled 'Online psychological interventions to reduce symptoms of depression, anxiety, and general distress in those with chronic health conditions', published in Psychological Medicine.
Depression and anxiety are among the most diagnosed mental health conditions in people with chronic pain, and comorbid pain and psychological distress are associated with a poorer prognosis and higher therapy resistance compared to either condition alone.
The systematic review concludes that traditional Cognitive Behavioral Therapy may produce significant benefits for the improvement of depression, anxiety, and quality of life, but not for pain intensity and pain catastrophizing.
An internet-based CBT program for stress and anxiety, as described in the systematic review, utilizes psychoeducation, mindfulness, and positive psychology over 10 sessions without therapists and experienced a 32% dropout rate.
Acceptance and commitment therapy (ACT) for anxiety was evaluated in 1 study, involving 78 participants in the intervention group and 78 in the control group, with 0% of studies showing positive results at post-treatment or follow-up.
The systematic review measured outcomes including pain-related variables (pain interference, intensity, acceptance, catastrophizing, and self-efficacy), emotional functioning (depression, anxiety, and stress), health-related quality of life, behavioral activation, and psychological flexibility.