Shorter sleep durations are linked with reduced density of slow-wave sleep activity in fronto-temporal regions and associated cortical thinning, possibly related to excessive wakeful neuronal activity.
The study findings support a target range of seven to nine hours of sleep for adults, which differs from some national guidelines that suggest seven hours or more with no upper boundary.
The study demonstrated a quadratic relationship between sleep duration and brain volume in several brain regions, while other areas showed lower volume only with longer sleep durations.
The researchers investigated the association between sleep duration and brain volume by comparing individuals who sleep six-to-eight hours against those with other sleep durations (N = 37,553).
A study of 613 participants found no association between sleep duration and overall grey and white matter volume.
After controlling for age using a quantile-based, age-residual analysis, seven hours of sleep was associated with the highest Executive Function score in the UK Biobank cohort.
Zitser, J. et al. conducted a prospective cohort study on sleep duration over 28 years in relation to cognition, gray matter volume, and white matter microstructure, published in Sleep in 2020.
The researchers emphasize the need for careful evaluation of sleep habits if an individual consistently falls outside a healthy sleep duration range, due to the relationship between sleep duration and both cognitive function and brain structural health.
In the study cohort, 48.5% of participants reported no change in sleep duration between baseline and imaging assessment, and 91.0% reported either the same sleep duration or a difference of only one hour.
Sleep duration remained stable across the age range of the UK Biobank cohort, centered around a median of seven hours.
The researchers performed sensitivity analyses on individual cognitive test performance and sleep duration to address potential bias in missing data when comparing against the Executive Function latent variable.
A sensitivity analysis of individual cognitive tasks used to create the Executive Function latent variable showed a quadratic relationship between sleep duration and performance in all tasks except one.
The pairs-matching cognitive task did not demonstrate a clear quadratic relationship with sleep duration, potentially due to a performance ceiling effect.
The scientific article titled 'Impact of sleep duration on executive function and brain structure' was authored by X.Y. Tai, C. Chen, S. Manohar, and others, and published in the journal Communications Biology in 2022.
Sleeping between six-to-eight hours is associated with greater grey matter volume in frontal, temporal, parietal, and cerebellar brain regions, according to the largest neuroimaging study to date using the UK Biobank cohort.
The study demonstrates that sleep duration is a modifiable lifestyle factor related to cognitive performance, which has implications for maintaining healthy cognitive aging in middle-to-late life individuals.
The UK Biobank is releasing actigraphy data intended to improve the resolution of sleep duration measurements and provide information about sleep quality for future studies.
A study on brain structural integrity and sleep duration found a widespread relationship between the two, consistent with longitudinal data associating poor sleep quality with an increased rate of atrophy in frontal, parietal, and temporal brain regions.
Seven hours of sleep per day is associated with the highest cognitive performance in middle-to-late life individuals, with performance decreasing for every hour of sleep below or above this duration.
Previous observational studies regarding sleep duration and cognition have been limited by small sample sizes or relatively insensitive cognitive measures.
The UK Biobank study measured subjective sleep duration in discrete one-hour blocks, a method that included daytime naps and resulted in a relatively insensitive measure of sleep.
The association between sleep duration and cognition is stronger in younger individuals but remains present in participants over 60 years old, based on analysis of the UK Biobank cohort.
Very long reported sleep durations may reflect mood-related chronic illnesses or hypersomnolence disorders such as obstructive sleep apnoea, which can impair cognitive processes directly or indirectly through poor sleep quality or sleep fragmentation.
The negative cognitive effects of very short (two to three hours) and very long (11 to 12 hours) sleep durations are more apparent in younger participants (38–59 years) than in older participants (60–73 years).
Volume in 56 brain regions significantly predicted executive function, while volume in 46 brain regions showed a significant quadratic relationship with sleep duration; 41 of these brain regions overlapped, including the hippocampi, thalami, orbitofrontal cortex, right frontal pole, left parahippocampal gyri, and cerebellar regions.
In the UK Biobank cohort, peak cognitive performance in middle-to-late healthy individuals is associated with seven hours of overnight sleep.
Sleep duration and cognitive performance show cross-sectional associations in the UK Biobank population, according to a 2017 study in Sleep Medicine.
Eight hours of sleep is associated with the lowest burden of white matter hyperintensities (WMH) in the brain.
The relationship between sleep duration and the Executive Function latent variable was visualized using a heatmap with a sample size of 479,420 participants.
Multiple regression analysis was used to test the relationship between sleep duration and the Executive Function latent variable while controlling for age, cardiovascular comorbidity, smoking pack years, BMI, genetic risk, and socioeconomic status.
Usual sleep duration is linked to cognitive function in older adults in Spain, according to a 2009 study in the Journal of Sleep Research.
Only a limited number of studies have explored the relationship between sleep duration and brain structure in middle-to-late life.
When comparing individuals sleeping six to eight hours against those sleeping longer than eight hours, 47 brain regions were significantly larger in the six-to-eight hour group, including 24 cerebellar sub-regions.
The sliding window approach used to study the relationship between age, Executive Function, and sleep duration does not assume a linear relationship between variables.
There is a quadratic, or 'u-shaped', relationship between sleep duration and both cognitive function and certain brain measures.
The mediation effect of brain volume on the relationship between sleep duration and executive function resulted in a significant drop in the beta value of a*b = 0.01 (p < 0.001).
Researchers have investigated sleep duration as a potential risk factor for dementia.
A longitudinal analysis of a 7,959-person sub-cohort of the Whitehall study found that sleeping six hours or less is associated with a higher risk of dementia compared to sleeping seven hours, while sleeping eight hours or more was not associated with higher risk.
A study of 613 participants did not find an association between sleep duration and overall grey and white matter volume, and a longitudinal assessment using latent class growth analysis suggested that the trajectory of sleep across 25 years did not impact brain structure.
Forty-one brain regions, including the hippocampi, thalami, orbitofrontal cortex, right frontal pole, left parahippocampal gyri, and cerebellar regions, showed both a significant quadratic relationship with sleep duration and predictive power for executive function.
Sleep duration is a predictive factor for cognitive function across age in middle-to-late healthy individuals, according to the study 'Impact of sleep duration on executive function and brain structure' published in Nature.
The multiple regression model examining the relationship between sleep duration and Executive Function controlled for age, sleep characteristics (chronotype, insomnia), obstructive sleep apnoea traits (daytime sleepiness, snoring), vascular co-morbidity, smoking, BMI, APOE ε4 genotype, and socioeconomic status.
Individuals with longer sleep durations in the study cohort exhibited a smaller cerebellum volume.
The study of sleep duration and cognitive function in the UK Biobank analyzed data from 479,420 middle-to-late life individuals aged 38–73 years.
The study on sleep duration and brain structure found that sleep duration is a modifiable lifestyle factor related to cognitive performance, with implications for maintaining healthy cognitive aging in middle-to-late life individuals.
Henry et al. investigated the relationship between sleep duration, cognition, and dementia using a Mendelian randomization study.
The six-to-eight hour sleep duration band used in the regression model was selected because seven hours of sleep is associated with the highest cognitive performance, and the one-hour buffer on either side accounts for self-reporting bias.
A sub-group of 37,553 individuals from the UK Biobank study was analyzed to determine the relationship between sleep duration and brain structure.
In the regression model, participants were assigned a score of one if their sleep duration was between six and eight hours, and a score of zero otherwise, to reflect the quadratic relationship between sleep duration and Executive Function.
The median self-reported daily sleep duration for the 479,420 individuals in the UK Biobank cohort was seven hours.
White Matter Hyperintensity (WMH) volume and sleep duration exhibit a quadratic relationship, similar to the relationship observed between sleep duration and other brain structural measures.
The current scientific literature lacks a clear parametric visualization of the relationship between sleep duration and cognition across age in later years.
In a study of 37,553 UK Biobank participants, 46 brain regions were significantly larger in volume in individuals who slept between six and eight hours compared to those with other sleep durations, including the orbital frontal cortex, pre-and post-central gyri, right frontal pole, hippocampi, and thalami.
The UK Biobank study measured sleep duration by asking participants to report the number of hours they sleep every 24 hours, with data collected during the initial UK Biobank assessment and again for participants who attended the imaging visit.
The researchers applied a mean smoothing factor of one hour for sleep duration and two years for age when visualizing the relationship between sleep duration and Executive Function.
A multiple regression analysis with Executive Function as the dependent variable demonstrated a quadratic relationship between sleep duration and Executive Function, comparing six-to-eight hour sleep durations to other reported sleep times.
Sleeping between six and eight hours remained predictive of higher brain volume in a regression model that controlled for baseline sleep characteristics, obstructive sleep apnoea traits, smoking, vascular co-morbidity, APOE ε status, body mass index, and socio-economic status.
Lo, J. C., Loh, K. K., Zheng, H., Sim, S. K. Y., and Chee, M. W. L. found that sleep duration is associated with age-related changes in brain structure and cognitive performance in a 2014 study published in the journal Sleep.
Longitudinal data indicates that longer sleep duration is associated with an increased rate of cortical thinning in the superior frontal gyrus.
The study examined the relationship between sleep duration and Executive Function age-residuals in younger participants (38–59 years, n = 262,409) and older participants (60–73 years, n = 212,006).
Spira, A. P. et al. examined the relationship between sleep duration and subsequent cortical thinning in cognitively normal older adults in a 2016 study published in Sleep.
A mendelian randomisation study on the UK Biobank cohort suggests that an optimal sleep duration exists to impact daily cognitive function and healthy cognitive ageing.
There were no brain regions that were significantly smaller in volume in the group of individuals who slept between six and eight hours compared to other sleep duration groups.
Sleeping between six and eight hours is a significant positive predictor of executive function, even after controlling for factors such as obstructive sleep apnoea traits.
A whole-brain study identified that longer sleep duration is associated with a thinner cortex in the left inferior occipital gyrus, while shorter sleep duration is associated with a smaller orbitofrontal cortex and precuneus.
Longitudinal data indicates that shorter sleep duration is associated with an increased rate of cortical thinning in the superior temporal gyrus, inferior frontal gyrus, and middle frontal gyrus.
The block duration approach assumes a linear relationship between cognition and sleep duration relative to a specific cut-off point.
The quadratic relationship between seven hours of sleep and optimal cognitive performance persists in individuals older than 60 years, based on an analysis of 212,006 individuals.
The researchers used a sliding window approach with an age window of fixed age-quantile widths and a smoothing Gaussian kernel of five to analyze the relationship between age, Executive Function, and sleep duration.
A Mendelian randomization study published in the International Journal of Epidemiology in 2019 examined the relationship between sleep duration, cognition, and dementia.
Researchers used permutation testing to analyze brain volume differences by shuffling datapoints for two different sleep duration groups across brain regions, testing 1000 permuted datasets per region.
A whole brain approach study identified that shorter sleep duration is related to a smaller orbitofrontal cortex and precuneus.
The heterogeneity of findings regarding sleep duration and brain structure may be explained by low sample sizes, which reduce statistical power, and the use of pre-specified region-of-interest approaches that may miss important brain areas related to sleep.
A multiple regression model using Executive Function as the dependent variable confirmed a quadratic relationship between sleep duration and cognitive performance, controlling for age, chronotype, insomnia, obstructive sleep apnoea traits, vascular co-morbidity, smoking, BMI, APOE ε4 genotype, and socioeconomic status.
In a sub-group of 37,898 individuals who underwent multi-modal brain imaging, researchers explored the relationship between sleep duration and brain volume.
Sleep duration is associated with white matter hyperintensity volume in older adults, as reported in the 2014 Northern Manhattan Study published in the Journal of Sleep Research.
The effect of sleep on cognition is similar across age groups, but older participants (60–73 years) show a smaller variance and range of Executive Function scores related to sleep duration compared to younger participants (38–59 years), with F (262,409, 212,006) = 1.01, 95% CI [1.0017, 1.0181], p = 0.017.
When comparing individuals sleeping six to eight hours against those sleeping less than six hours, the six-to-eight hour group had larger volumes in seven regions: the orbitofrontal cortex and precentral gyrus bilaterally, the right frontal pole, the right posterior cingulate, and the right amygdala.
The study of sleep duration and brain structure analyzed cross-sectional data from the UK Biobank cohort, which consists of individuals with a higher socioeconomic baseline and fewer comorbid diseases compared to the general population.
Ramos, A. R. et al. examined the association between sleep duration and the mini-mental score in the Northern Manhattan Study, published in the Journal of Clinical Sleep Medicine in 2013.
Researchers defined 'sleep-related brain regions' as those exhibiting a significant quadratic relationship with sleep duration, calculated by performing a z-score transformation of regional volume and averaging across regions.
Sleeping between six and eight hours is significantly associated with higher executive function, and this relationship is partially mediated by brain volume in sleep-related regions.
Individuals who sleep between six and eight hours have significantly lower white matter hyperintensity (WMH) volume compared to individuals with other sleep durations, based on permutation testing with Bonferroni correction.
Several individual brain regions showed a quadratic or inverted ‘u’-shape relationship between sleep duration and grey matter volume, while more areas showed smaller volume specifically with longer sleep duration.
Volume in 56 brain regions significantly predicted executive function, while volume in 46 brain regions showed a significant quadratic relationship with sleep duration.
Seven hours of sleep is associated with the highest Executive Function score when controlling for age, a pattern observed in both younger and older participant groups in the study 'Impact of sleep duration on executive function and brain structure'.
The study analyzed sleep duration and Executive Function in two age subgroups: younger participants (<60 years, N = 264,935) and older participants (>60 years, N = 212,006).
The study examined the relationship between sleep duration and cognitive performance in 479,420 healthy individuals aged 38 to 73, using data from the UK Biobank.
Ramos et al. found that sleep duration is associated with white matter hyperintensity volume in older adults in the Northern Manhattan Study.
Sleep duration exhibits a quadratic relationship with cognitive performance, where performance worsens as sleep duration decreases from six to three hours or increases from eight to 12 hours.
Previous studies using UK Biobank cognitive tests associated sleeping 10 hours or more (long sleep) and six hours or less (short sleep) with worse cognitive performance.
Self-reported sleep duration data in the UK Biobank study may be subject to reporting inaccuracy and recall bias, as older adults often report longer sleep durations than objective measurements indicate, particularly when sleep quality is poor.
Regional brain volume differences between individuals who slept six-to-eight hours compared to other durations were correlated (r2 = 0.32, p < 0.001) with the strength of regional brain volume predicting executive function.
Among the study participants, 48.5% reported no change in sleep duration between two timepoints, and 91.0% reported either the same sleep duration or a difference of only one hour.