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white matter hyperintensities
Also known as: WMH, white matter hyperintensity burden, white matter hyperintensity
Facts (11)
Sources
Impact of sleep duration on executive function and brain structure nature.com Mar 3, 2022 11 facts
referenceThe study 'Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden' was published in Alzheimer's Research & Therapy in 2025.
procedureThe Brain Intensity Abnormality Classification Algorithm (BIANCA) is an automated method used for white matter hyperintensity (WMH) segmentation by classifying voxels based on relative intensity and spatial features.
referenceWhite matter hyperintensities are considered a brain marker closely related to cardiovascular burden.
claimEight hours of sleep is associated with the lowest burden of white matter hyperintensities (WMH) in the brain.
claimWhite matter hyperintensity (WMH) volume is considered a structural marker of cerebrovascular burden on the ageing brain.
measurementIndividuals who slept between six and eight hours exhibited a smaller volume of white matter hyperintensities.
measurementIndividuals who slept between six-to-eight hours exhibited a smaller volume of white matter hyperintensities, which is a brain marker closely related to cardiovascular burden.
claimWhite Matter Hyperintensity (WMH) volume and sleep duration exhibit a quadratic relationship, similar to the relationship observed between sleep duration and other brain structural measures.
referenceGriffanti, L. et al. published 'BIANCA (Brain Intensity AbNormality Classification Algorithm): A new tool for automated segmentation of white matter hyperintensities' in the journal Neuroimage in 2016.
referenceWhite matter hyperintensities are a factor in vascular contributions to cognitive impairment and dementia (VCID), as identified in a 2019 review in Alzheimer’s & Dementia.
measurementIndividuals who sleep between six and eight hours have significantly lower white matter hyperintensity (WMH) volume compared to individuals with other sleep durations, based on permutation testing with Bonferroni correction.