concept

flavonoids

Also known as: flavonoid

Facts (88)

Sources
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org Frontiers in Immunology 21 facts
claimFlavonoids are effective against multidrug-resistant (MDR) bacteria of both Gram-negative and Gram-positive types.
claimEchinacosides and flavonoids, bioactive compounds found in Echinacea purpurea (purple coneflower), are effective against the MDR microorganism Staphylococcus aureus.
claimThe chemotaxonomic method for selecting medicinal plants relies on the presence of specific chemotaxonomic markers within a plant family or genus, which involves phytochemical screening to detect active biological markers such as flavonoids and alkaloids.
claimFlavonoids exhibit redox activity that impacts human health, therapeutics, and chemical safety.
referenceUllah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, et al. authored 'Important flavonoids and their role as a therapeutic agent' published in Molecules in 2020.
claimBioactive chemicals in medicinal plants, such as terpenoids, flavonoids, and alkaloids, engage with microbial cell membranes to cause structural impairment.
claimFlavonoids derived from Chimonanthus salicifolius influence ATPase activity in Pseudomonas aeruginosa and Staphylococcus aureus, impeding their development.
claimPolyphenols are categorized into four distinct groups: phenolic acids, flavonoids, tannins, and stilbenes.
claimFlavonoids including quercetin and apigenin, and phenolic acids including ellagic acid and caffeic acid, impede biofilm formation in Candida species, including the drug-resistant Candida auris.
claimHypericin and flavonoids, bioactive compounds found in Hypericum perforatum (St John’s wort), are effective against the MDR microorganism Staphylococcus aureus.
claimFlavonoids are a subset of polyphenolic compounds that encompass over 9,000 recognized natural molecules.
claimMedicinal plants contain a complex array of bioactive chemicals, including alkaloids, terpenoids, flavonoids, and phenolics, which create a 'cocktail' effect that challenges bacteria attempting to acquire resistance.
claimFlavonoids possess antiallergic, antidiabetic, anti-inflammatory, antiviral, antibacterial, antifungal, antiproliferative, anticarcinogenic, hepatoprotective, and antioxidant properties.
claimFlavonoids, including quercetin and apigenin, inhibit the production of peptidoglycan, which is an essential component of the bacterial cell wall.
claimMedicinal plants contain diverse bioactive chemicals including coumarins, flavonoids, phenolics, alkaloids, terpenoids, tannins, essential oils, lectins, polypeptides, and polyacetylenes.
claimFlavonoids compromise the cell membranes of Candida species by increasing permeability and disrupting membrane protein functionality.
claimFlavonoids can elicit aberrant multicellular aggregation in Staphylococcus aureus, which inhibits the formation of structured biofilm formations.
claimFlavonoids from Chimonanthus salicifolius SY Hu. demonstrate antibacterial activity against Staphylococcus aureus, with mechanisms analyzed via transcriptome analysis.
claimThe polyphenol curcumin regulates efflux pump activity in yeast, while many flavonoids exhibit comparable inhibitory effects in fungi, resulting in cellular mortality.
claimAlkaloids, including ellagic and tannic acids, along with various flavonoids, impede efflux pump activity in bacteria such as Acinetobacter baumannii.
claimFlavonoids, specifically phloretin, impede biofilm development in Escherichia coli by downregulating curli gene expression, which limits fimbriae formation.
Investigation of nutritional and phytochemical properties of wild ... nature.com Nature Dec 9, 2025 13 facts
claimRutin is a flavonoid with antioxidant, anti-inflammatory, and vascular-protective effects; Gallic acid and Protocatechuic acid are phenolic acids with antimicrobial and radical-scavenging properties; and P-coumaric acid and Ferulic acid are hydroxycinnamic acids that contribute to antioxidant capacity and metabolic pathway modulation.
claimThe quantitative analysis of Achyranthes aspera L. leaves, Berberis lycium Royle roots, and Vitex negundo L. leaves was performed using UPLC-PDA, which confirmed the presence of polyphenols and flavonoids in their methanolic extracts.
claimSecondary phytochemical screening identifies bioactive compounds such as alkaloids, flavonoids, phenols, saponins, and tannins, which are responsible for the therapeutic efficacy of plants.
procedureThe standard stock solution for UPLC-PDA analysis of phenolic acids and flavonoids is formulated at a concentration of 1 mg/mL by dissolving standards in LC-MS grade methanol, filtering through a 0.22 μm syringe filter, and storing at 4 °C.
claimThe medicinal plants studied in the Renukaji Wildlife Sanctuary contain bioactive compounds including saponins, alkaloids, and flavonoids, as well as essential minerals including Na, N, K, P, Zn, Fe, Cu, Mn, Ca, Mg, and S.
claimPlants contain phytochemicals such as alkaloids, flavonoids, phenols, saponins, and tannins, which often exhibit antioxidant, antimicrobial, and anti-inflammatory properties.
referenceUltra Performance Liquid Chromatography–Photodiode Array (UPLC-PDA) is an analytical technique used to identify and quantify phytochemicals in plant materials by detecting bioactive compounds like polyphenols, flavonoids, and alkaloids based on their UV absorbance and retention time.
claimThe phenolic acids and flavonoids analyzed via UPLC-PDA include P-coumaric acid, Gallic acid, Pro-catechuic acid, Vanillic acid, Rutin, Syringic acid, Caffeic acid, Epicatechin, EGCG, Ferulic acid, Quercetin, and Kaempferol.
procedureQuantification of phenolic acids and flavonoids is performed using a Waters Acquity UPLC H-class system with an ACE Ultra Core 2.5 Super C18 column (2.1 mm X 100 mm, 2.5 μm) and detection set at 270 nm.
claimThe study of the nutraceutical value of medicinal plants aims to confirm traditional uses, understand nutritional and medicinal benefits, encourage use as natural health supplements, support conservation, and examine the presence of polyphenols and flavonoids in methanolic extract using 270 nm wavelength.
claimGallic acid is a phenolic acid with antioxidant and antimicrobial properties, while Epicatechin is a flavonoid known for antioxidant, anti-inflammatory, and cardioprotective effects.
claimPhytoconstituents are bioactive compounds found in vegetation, such as flavonoids, alkaloids, and saponins, that possess medicinal properties and contribute to therapeutic effects.
claimResearchers analyzed the medicinal plants Achyranthes aspera L., Berberis lycium Royle, and Vitex negundo L. gathered from the Renukaji Wildlife Sanctuary in Sirmaur for polyphenols and flavonoids using the UPLC-PDA method (Waters Acquity UPLC H-class).
Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 12 facts
perspectiveThe use of flavonoids as non-nucleoside reverse transcriptase inhibitors is a potential strategy for HIV treatment and an innovative approach for antiviral medication development.
claimSelective inhibition of cyclooxygenase-2 (COX-2) by certain flavonoids provides anti-inflammatory benefits while preserving the gastrointestinal protective function of COX-1, thereby reducing the risk of side effects associated with non-selective NSAIDs.
claimFlavonoids impair bacterial cellular energy production by affecting the electron transport chain, leading to cell death.
claimFlavonoids acting as non-nucleoside reverse transcriptase inhibitors bind to allosteric sites on the enzyme, causing conformational changes that reduce activity and processivity.
claimFlavonoids modulate COX-2 gene expression by inhibiting transcription factors such as NF-κB and AP-1, resulting in prolonged anti-inflammatory effects.
claimFlavonoids, such as apigenin and luteolin, inhibit cyclin-dependent kinases, which are required for cell cycle progression.
claimSpecific flavonoids function as non-nucleoside reverse transcriptase inhibitors to interfere with viral replication processes.
claimFlavonoids, including quercetin from onions and apples, rutin from buckwheat, and anthocyanins from blueberries and blackberries, bolster blood–brain barrier integrity by fortifying tight junction proteins and diminishing oxidative stress-induced permeability.
claimFlavonoids improve vascular function and regulate blood pressure by augmenting endothelial nitric oxide synthase (eNOS) activity, diminishing nitric oxide breakdown, increasing eNOS expression, improving enzyme coupling, and supplying cofactors for nitric oxide synthesis.
claimFlavonoids inhibit viral protease activity, which obstructs polyprotein processing and viral maturation.
claimMedicinal plants contain primary and secondary metabolites categorized as bioactive compounds, including alkaloids, steroids, tannins, phenolic compounds, and flavonoids, which can elicit physiological effects on the human body.
claimFlavonoids inhibit NF-κB activation and reduce viral transcription from integrated proviral DNA.
Vernonia amygdalina: a comprehensive review of the ... frontiersin.org Frontiers 9 facts
measurementVernonia amygdalina contains 305 mg/g of flavonoids, 104 mg/g of phytate, 6 mg/g of saponin, 1.7 mg/mL of tannin, and 20 mg/mL of alkaloids.
measurementThe ethanol extract of Vernonia amygdalina contains 99 mg/g of tannins, 70 mg/g of flavonoids, 64 mg/g of saponins, 36 mg/g of phenols, and 32 mg/g of alkaloids.
claimPhytochemicals found in Vernonia amygdalina—specifically alkaloids, flavonoids, terpenoids, phenolics, and tannins—exhibit biological activities including antimicrobial effects, antioxidant properties, disease prevention and therapy, free radical scavenging, anticancer activity, and antiviral potential.
claimPhytochemical screening of ethanol and aqueous leaf extracts of Vernonia amygdalina revealed the presence of flavonoids, alkaloids, saponins, tannins, triterpenoids, steroids, and cardiac glycosides.
measurementVernonia amygdalina (bitter leaf) contains 139 mg/g of alkaloids, 180 mg/g of flavonoids, 60 mg/g of saponin, 2.3 mg/g of oxalate, and 167 mg/g of phytate.
claimChemical analysis of Vernonia amygdalina reveals the presence of flavonoids, alkaloids, saponins, tannins, triterpenoids, sesquiterpene lactones, steroids, cardiac glycosides, oxalates, phytates, cyanogenic glycosides, and phenols.
claimThe nutritional composition of Vernonia amygdalina is rich in vital nutrients, vitamins, and minerals, while its biological and pharmacological characteristics are determined by phytochemicals including flavonoids, alkaloids, terpenoids, and phenolic compounds.
claimVernonia amygdalina contains numerous phytochemicals including alkaloids, glycosides, sesquiterpene lactones, steroids, flavonoids, proanthocyanidins, tannins, terpenoids, phenylpropanoids, resins, lignans, furocoumarines, naphthodianthrones, proteins, and peptides.
measurementThe aqueous leaf extract of Vernonia amygdalina contains 27 mg/g of saponins, 46 mg/g of alkaloids, 122 mg/g of flavonoids, 17 mg/g of terpenoids, 12 mg/g of tannins, 48 mg/g of steroids, and 36 mg/g of phenols.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 9 facts
referenceHusain A, Ahmad A, Mujeeb M, Khan SA, and Alghamdi AG (2015) performed a quantitative analysis of total phenolic and flavonoid contents and HPTLC fingerprinting for the standardization of Glycyrrhiza glabra roots in the journal Herb Med.
claimOcimum basilicum Linn. contains secondary metabolites including essential oils, phenols, flavonoids, anthocyanins, tannins, and steroids, along with minerals such as Fe, Ca, Mg, P, Mn, Na, K, and Zn.
claimHerbal plant infusions available as ready-to-serve drinks, instant tea, or squashes possess antidiabetic properties due to the presence of functional ingredients including phenols, flavonoids, tannins, alkaloids, and essential oils, which increase sugar metabolism by stimulating insulin secretion and maximizing sugar excretion through renal diuresis.
claimSilybum marianum contains flavonoids and fatty oils as its two major compound groups.
claimFlavonoid-rich extract of Murraya koenigii alleviates in-vitro LDL oxidation and oxidized LDL-induced apoptosis in raw 264.7 Murine macrophage cells.
claimThe medicinal properties of Murraya koenigii are attributed to carbazole alkaloids and various chemical constituents, including terpenoids, flavonoids, dihydropyridines, carbohydrates, carotenoids, vitamins, and nicotinic acid.
claimSilybum marianum contains the flavonoid compounds taxifolin, dihydrokaempferol, and quercetin.
claimVitex Negundo, also known as the chaste tree, contains bioactive compounds including volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids in its leaves, seeds, and roots.
claimPreliminary phytochemical analysis indicates that Ocimum basilicum Linn. contains terpenoids, alkaloids, phenolics, flavonoids, tannins, saponin, reducing sugars, cardiac glycosides, steroids, and glycosides.
Active Plant Principles and Applications in Plant Medicine irispublishers.com Daniela Rebeca Ardelean, Ramona Stef, Monica Butnariu · Iris Publishers May 2, 2024 7 facts
claimThe herbaceous species Hypericum perforatum (St. John’s wort) contains flavonoids, with rutoside being the most important constituent.
claimHeterosides are classified into several subgroups based on the chemical nature of their aglycone: aliphatic, seneval, cyanogenetic, glycoalkaloids, anthracenosides, cardiotonic heterosides, saponosides, flavonoids, and heterosides of unknown structure.
claimFlavonoids are subdivided into several series of compounds, including flavones and anthocyanins, depending on their degree of oxidation.
claimFlavonoids possess anti-inflammatory properties that improve peripheral blood circulation, increase the resistance of blood capillary walls to prevent hemorrhages, exhibit antibiotic and antiviral properties, and protect the human body against radiation by weakening the action of histamine.
claimMore than 500 natural flavonoids have been identified across various plant families and species, and this number is constantly increasing.
claimBurdock root (Arctium lappa) and its related species contain the flavonoid arctein.
claimFlavonoids are natural plant-derived substances, specifically derivatives of benzopyr with a phenyl radical, that function as colored pigments in flowers and fruits.
Ethnobotanical and Food Composition Monographs of Selected ... ouci.dntb.gov.ua Javier Tardío, María de Cortes Sánchez-Mata, Ramón Morales, María Molina, Patricia García-Herrera, Patricia Morales, Carmen Díez-Marqués, Virginia Fernández-Ruiz, Montaña Cámara, Manuel Pardo-de-Santayana, María Cruz Matallana-González, Brígida María Ruiz-Rodríguez, Daniel Sánchez-Mata 3 facts
measurementThe seeds of Ziziphus lotus contain significantly higher levels of protein (8.37 to 27.75%), lipid (35.39 to 48.01%), potassium (125.874 to 325.408 mg. 100−1 g), polyphenol (439.465 to 1349.46 mg.GAE.100 g−1), flavonoid (83.908 to 98.259 mg.QE.100 g−1), tannins (55.268 to 277.94 mg.GAE.100 g−1), and chlorophyll b (11.2 to 30.4 μg g−1) compared to the fruit pulp.
measurementPlantago coronopus exhibited the highest ability to accumulate selenium among the tested wild herb microgreens, and the selenium-enriched microgreens showed the highest chlorophyll and flavonoid content.
referenceF. Conforti et al. published a study in 2009 in Food Chemistry regarding the protective ability of Mediterranean dietary plants against oxidative damage, specifically examining the role of radical oxygen species in inflammation and the content of polyphenols, flavonoids, and sterols.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu International Academic Publishing House 3 facts
referenceDas et al. (2024) published a study in the book 'Neuroprotective Effects of Phytochemicals in Brain Ageing' detailing the role of flavonoids as neuroprotectants and their effects on age-related neurodegenerative disorders.
claimNair et al. (2006) found that the flavonoid Quercetin inhibits proinflammatory cytokine (Tumor Necrosis Factor Alpha) gene expression in normal peripheral blood mononuclear cells by modulating the NF-κβ system.
claimSecondary metabolites found in medicinal plants, including flavonoids, tannins, phenolic acids, terpenoids, alkaloids, coumarins, essential oils, and polypeptides, possess antibacterial, anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and immunomodulatory properties.
Advances in Pharmacognosy for Modern Drug Discovery and ... jbph.org Journal of Basic and Pharmaceutical Health 3 facts
referenceZou L, Li H, Ding X, Liu Z, He D, Kowah JAH, et al. published a review on the application of spectroscopy to flavonoids from medicine and food homology materials in Molecules in 2022.
referenceTungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. published an overview in Medicines (2018) regarding the pharmaceutical and medical aspects of flavonoids and other phenolic compounds derived from medicinal plants.
referenceFlavonoids may act as modulators of brain function.
Medicinal plants meet modern biodiversity science - OUCI ouci.dntb.gov.ua Charles C. Davis, Patrick Choisy · Elsevier BV 2 facts
claimPhytochemical analysis of Dichrostachys cinerea confirms the presence of biologically active compounds including flavonoids, polyphenols, alkaloids, saponins, terpenoids, and tannins.
claimAn inverse correlation between total chlorophyll and flavonoid content in Mikania laevigata highlights a trade-off between photosynthetic pigment synthesis and secondary metabolism.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua Bhanumati Sarkar, Paramita Biswas, Suman Adhikari · International Academic Publishing House (IAPH) 2 facts
claimDas, S.K., Sen, K., Sanyal, T., Saha, A., & Madhu, N.R. (2024) assert that flavonoids act as neuroprotectants and have salutary effects on age-related neurodegenerative disorders.
claimProminent bioactive compounds found in medicinal plants include flavonoids, tannins, phenolic acids, terpenoids, alkaloids, coumarins, essential oils, and polypeptides.
Ethnobotanical study of food plants used in traditional medicine in ... link.springer.com Springer Nov 26, 2025 1 fact
referenceFabaceae species are valued in traditional medicine due to their phytochemical richness, specifically the presence of bioactive compounds such as flavonoids, alkaloids, and coumarins, as noted in the source cited as [31].
A Comprehensive Review on the Therapeutic Properties of ... traditionalmedicine.actabotanica.org Acta Botanica 1 fact
claimMedicinal plants contain various chemical compounds, including alkaloids, flavonoids, terpenoids, and phenolic compounds, which contribute to their medicinal properties.
Medicinal Plant - an overview | ScienceDirect Topics sciencedirect.com ScienceDirect 1 fact
claimPlant extracts containing flavonoids, alkaloids, and sterols function as anti-oxidants and anti-inflammatory agents by reducing free radicals.
Ethnobotanical study of wild edible plants in the mountainous ... link.springer.com Springer Oct 4, 2024 1 fact
claimCrataegus species are abundant in amino acids, minerals, vitamins, and bioactive components such as polyphenols, flavonoids, and triterpenoids.