Knowledge Tree
phytochemicals
Also known as: phytochemical, plant phytochemicals, phytochemical compounds
Facts (70)
Sources
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 16 facts
claimPhytochemicals offer advantages over traditional chemotherapeutic drugs, including lower systemic toxicity, multi-target efficacy, and the ability to overcome drug resistance mechanisms.
claimInnovative delivery systems, including liposomal formulations, nanoparticle encapsulation, and prodrug techniques, mitigate the bioavailability constraints of phytochemicals, thereby enhancing therapeutic efficacy and minimizing necessary dosages.
claimAcharya (2024) states that incorporating phytochemicals with traditional therapies requires evaluating pharmacokinetic interactions and synergistic effects to enhance therapeutic advantages while reducing adverse effects.
claimSpecific phytochemicals activate the Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) pathway, resulting in the upregulation of Phase II detoxification enzymes and endogenous antioxidant systems.
claimContemporary cancer research indicates that effective treatment requires the simultaneous targeting of cancer stem cells, the tumor microenvironment, and resistance pathways, areas where phytochemicals show potential.
referenceTaleghani, Eghbali, Moghimi, and Mokaber-Esfahani (2024) analyzed the phytochemical, antioxidant, and antimicrobial potentials of Crataegus pentagyna Willd. fruits, leaves, and roots.
claimPhytochemicals inhibit cancer metastasis and growth by preventing angiogenesis and cellular invasion, as reported by Utpal et al. (2025).
claimSophisticated delivery systems for phytochemicals safeguard chemicals against degradation, improve cellular absorption, and offer regulated release patterns, including targeted administration to specific tissues, traversing biological barriers, and circumventing efflux pump processes.
claimThe stimulation of EDHF pathways by phytochemicals is particularly beneficial for vascular control in aging and diabetes patients, where conventional vasodilatory mechanisms may be compromised.
claimCertain phytochemicals stimulate endothelium-derived hyperpolarizing factor (EDHF) pathways by activating calcium-activated potassium channels, which causes smooth muscle hyperpolarization and vasodilation independently of nitric oxide and prostacyclin pathways.
referenceSrivastava, Singh, and Singh (2023) reviewed drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy.
claimPhytochemicals, including alkaloids, phenolic compounds, terpenoids, and sulfur-containing molecules, demonstrate significant pharmacological capabilities that have placed them at the forefront of modern drug development and therapeutic innovation.
referenceAhmed MB, Islam SU, Alghamdi AA, Kamran M, Ahsan H, and Lee YS (2022) authored 'Phytochemicals as chemo-preventive agents and signaling molecule modulators: current role in cancer therapeutics and inflammation', published in the International Journal of Molecular Sciences, volume 23, issue 24, article 15765.
referencePhytochemicals are being investigated as a potential solution for combating antibiotic resistance in microbial pathogens, as explored by Khare et al. (2021).
claimPhytochemicals exert antioxidant effects through direct radical scavenging, metal chelation, and the upregulation of enzymatic antioxidant systems.
procedureMethodologies for evaluating combination therapies involving phytochemicals include preclinical investigations, pharmacokinetic modeling, and meticulously structured clinical trials.
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 11 facts
referenceSuganya et al. (2023) investigated methods for tackling multiple-drug-resistant bacteria using conventional and complex phytochemicals.
claimThe intricate amalgamation of phytochemicals in medicinal plants can demonstrate synergistic effects, where the collective activity of the compounds surpasses the sum of the individual constituents, potentially augmenting antibacterial efficacy and diminishing the probability of resistance emergence.
claimThe MTT assay indicated that (+)-nootkatone displays no toxicity to human foreskin fibroblast (HFF) cells, suggesting it is a potentially safe phytochemical for application in the food industry.
claimPhytochemicals from medicinal plants possess antioxidant, antibacterial, and antifungal activities.
referenceDiris M, Basri A, Metali F, Ahmad N, and Taha H published a 2017 study in the Research Journal of Phytochemistry titled 'Phytochemicals and antimicrobial activities of Melastoma malabathricum and Melastoma beccarianum leaf crude extracts', which investigates the phytochemical and antimicrobial properties of these two species.
referenceQi Y, Zhang Q, and Zhu H reviewed the phytochemical, pharmacological, and pharmacokinetic investigations of the Huang-Lian Jie-Du decoction in Chinese Medicine (2019).
claimResearch on the screening, identification, and characterization of plant constituents is considered crucial for discovering novel phytochemicals with antimicrobial activities.
referenceKhameneh et al. (2021) discussed the potential of phytochemicals as a treatment against antibiotic-resistant bacteria in the journal Antibiotics.
referenceHan A-R, Kim H, Piao D, Jung C-H, Seo EK reviewed the phytochemicals and bioactivities of Zingiber cassumunar Roxb.
claimScientific and pharmaceutical communities are increasingly interested in medicinal plants as potential sources of antimicrobial drugs, with selective screening of phytochemicals through medical data serving as a dependable approach for identifying innovative medicines.
claimTailored therapeutic approaches using phytotherapeutics can be facilitated by comprehending the interplay between phytochemicals and specific patients, considering factors such as personal genetic composition, gut microbiota, and additional variables.
Vernonia amygdalina: a comprehensive review of the ... frontiersin.org 8 facts
claimInvestigations into Vernonia amygdalina demonstrate notable chemical variations between plant preparations or extracts in terms of both the type and quantity of phytochemicals present.
referenceOgunnowo et al. (2010) conducted a comparative antioxidant, phytochemical, and proximate analysis of aqueous and methanolic extracts of Vernonia amygdalina and Talinum triangulare.
referenceLyumugabe Loshima F., Uyisenga J. P., Bayingana C., and Songa E. B. (2017) analyzed the antimicrobial activity and phytochemicals of Vernonia aemulans, Vernonia amygdalina, Lantana camara, and Markhamia lutea leaves for use as natural beer preservatives.
claimFuture research on Vernonia amygdalina should clarify the mechanisms of action of important phytochemicals, conduct clinical trials to support conventional claims, investigate possible synergistic effects of compounds, and create standardized formulations for therapeutic applications.
referenceTula et al. performed a systematic study comparing the phytochemicals and antimicrobial activities of different parts of the plant Vernonia amygdalina in 2012.
claimThe nutritional composition of Vernonia amygdalina is rich in vital nutrients, vitamins, and minerals, while its biological and pharmacological characteristics are determined by phytochemicals including flavonoids, alkaloids, terpenoids, and phenolic compounds.
claimVernonia amygdalina contains numerous phytochemicals including alkaloids, glycosides, sesquiterpene lactones, steroids, flavonoids, proanthocyanidins, tannins, terpenoids, phenylpropanoids, resins, lignans, furocoumarines, naphthodianthrones, proteins, and peptides.
referenceDegu S., Meresa A., Animaw Z., Jegnie M., Asfaw A., and Tegegn G. published a comprehensive review titled 'Vernonia amygdalina: a comprehensive review of the nutritional makeup, traditional medicinal use, and pharmacology of isolated phytochemicals and compounds' in Frontiers in Natural Products.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 7 facts
claimPhytochemicals can extend longevity, as explored by Leonov, A., Arlia-Ciommo, A., Piano, A., Svistkova, V., Lutchman, V., Medkour, Y., and Titorenko, V. I. in 2015.
referenceDarro and Khan (2024) provided an ethno-medicinal, phytochemical, and physico-chemical characterization of selected endangered medicinal plants from Indravati National Park in Chhattisgarh, India, in the International Journal of Experimental Research and Review.
referenceBanerjee et al. (2014) review the pharmacological activities and medicinal uses of phytochemicals found in Lycopodium clavatum.
referencePhootha et al. (2022) conducted a systematic review on the potential of plants and phytochemicals in treating anxiety, published in Phytomedicine Plus.
referenceAyaz et al. (2019) propose that the synergistic interaction of phytochemicals with antimicrobial agents is a potential strategy to counteract drug resistance.
claimHyptis spicigera leaves contain phytochemicals that can be extracted and analyzed, as reported by Idi and Muhammad (2021).
referenceBachheti et al. (2022) review the use of plant phytochemicals for the prevention and treatment of cardiovascular diseases.
Investigation of nutritional and phytochemical properties of wild ... nature.com Dec 9, 2025 5 facts
claimMedicinal plants in the research area contain a significant number of phytochemicals and minerals, which are integral to evaluating their medicinal properties and safety for use in folk and complementary drugs.
claimPhytochemicals exhibit antioxidant, antimicrobial, and anticancer activities, supporting the use of medicinal plants in treating a wide range of health conditions.
claimPlants contain phytochemicals such as alkaloids, flavonoids, phenols, saponins, and tannins, which often exhibit antioxidant, antimicrobial, and anti-inflammatory properties.
referenceUltra Performance Liquid Chromatography–Photodiode Array (UPLC-PDA) is an analytical technique used to identify and quantify phytochemicals in plant materials by detecting bioactive compounds like polyphenols, flavonoids, and alkaloids based on their UV absorbance and retention time.
claimThe phytochemicals found in the studied medicinal plants exhibit antioxidant and anticancer properties, offering potential for the development of new pharmaceuticals and nutraceuticals.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 4 facts
referenceR. K. Bachheti, L. A. Worku, Y. H. Gonfa, M. Zebeaman, Deepti, D. P. Pandey, and A. Bachheti reviewed the use of plant phytochemicals for the prevention and treatment of cardiovascular diseases in a 2022 article published in Evidence-Based Complementary and Alternative Medicine.
referenceLeonov et al. (2015) reviewed the extension of longevity through the use of phytochemicals.
referenceM. Ayaz, F. Ullah, A. Sadiq, F. Ullah, M. Ovais, J. Ahmed, and H. P. Devkota examined the synergistic interactions of phytochemicals with antimicrobial agents as a strategy to counteract drug resistance in a 2019 article published in Chemico-Biological Interactions.
claimPhytochemicals in medicinal plants possess antibacterial, anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and immunomodulatory properties.
A critical review of industrial fiber hemp anatomy, agronomic ... bioresources.cnr.ncsu.edu 3 facts
claimHemp leaves contain higher concentrations of phytochemicals due to their chronological arrangement from the root to the top of the plant.
referenceLiu, Y., Xiao, A. P., Cheng, H., Liu, L. L., Kong, K. W., Liu, H. Y., Wu, D. T., Li, H. Bin, and Gan, R. Y. (2022) analyzed the phytochemical differences of hemp (Cannabis sativa L.) leaves from different germplasms and their regulatory effects on lipopolysaccharide-induced inflammation in Matin-Darby canine kidney cell lines.
claimHemp leaves and inflorescences are utilized as sources of phytochemicals for therapeutic applications, offering antioxidant, anti-inflammatory, and hypoglycemic effects.
Advances in Pharmacognosy for Modern Drug Discovery and ... jbph.org 3 facts
referenceRaj A and Jhariya MK published 'Conservation and sustainable uses of medicinal plants phytochemicals' in the book 'Herbal Medicine Phytochemistry: Applications and Trends' in 2024.
referenceBitwell C, Indra SS, Luke C, and Maseka KK published a review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants in Scientific African in 2023.
referencePriya S and Satheeshkumar P authored a chapter on natural products from plants, focusing on phytochemicals, phytopharmaceuticals, and plant-based nutraceuticals as anticancer agents, published in 'Functional Preservation of Phytochemicals' in 2020.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 3 facts
claimMousavi, MohdSalleh, and Murugaiyah (2018) identified phytochemical and bioactive compounds in the methanol extract and fractions of Ocimum tenuiflorum leaves, noting its anti-diabetic potential.
claimPhytochemicals reduce inflammation, improve metabolic processes, inhibit cancer cell growth, protect the body from free radical damage associated with aging and chronic disease, boost the immune system, and reduce cholesterol.
claimPlant phytochemicals possess higher antioxidant properties than chemically synthesized medicines, specifically acting as radical scavengers, hydrogen donors, and singlet oxygen quenchers.
Ethnobotanical study of food plants used in traditional medicine in ... link.springer.com Nov 26, 2025 2 facts
referenceMasengo CA, Vulenga GK, Mawunu M, Tshibangu DS, Mpiana PT, and Ngbolua K-T-N conducted ethnobotanical, phytochemical, and pharmacological studies of the red-leaf hibiscus (Hibiscus acetosella), published in the Moroccan Journal of Agricultural and Veterinary Sciences in 2024.
referenceCoria-Téllez et al. (2018) published 'Annona muricata: a comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity' in the Arab J Chem, providing a detailed scientific review of the plant Annona muricata.
Ethnobotanical and Food Composition Monographs of Selected ... ouci.dntb.gov.ua 2 facts
referenceGarcía-Herrera P et al. published a study in 2014 in Food Research International regarding the nutrients, phytochemicals, and antioxidant activity in wild populations of Allium ampeloprasum, identifying it as a valuable underutilized vegetable.
referenceBarros, Carvalho, Morais, and Ferreira (2010b) published a detailed characterization of nutrients and phytochemicals with antioxidant properties found in strawberry-tree, blackthorn, and rose fruits in the journal Food Chemistry.
Medicinal plants: bioactive compounds, biological activities ... - PMC pmc.ncbi.nlm.nih.gov 1 fact
claimNaturally occurring phytochemicals found in medicinal plants have demonstrated diverse advantageous qualities, including antioxidant, antibacterial, and antifungal activity, as reported in the article 'Medicinal plants: bioactive compounds, biological activities ... - PMC' (citation 173).
A Review on Traditional Uses, Phytochemistry and Pharmacological ... journals.sagepub.com Jun 11, 2024 1 fact
referenceThe review article titled 'A Review on Traditional Uses, Phytochemistry and Pharmacological ...' compiles information regarding the pharmacological activities, traditional medicinal uses, and phytochemicals present in the plant genus Calendula.
Bioactive Compounds from Medicinal Plants and Their Importance ... ideas.repec.org 1 fact
claimHafiza Salaha Mahrosh and Ghulam Mustafa authored a 2021 study titled 'An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals,' which cites the article 'Bioactive Compounds from Medicinal Plants and Their Importance in Drug Discovery in Pakistan.'
A Comprehensive Review on the Therapeutic Properties of ... traditionalmedicine.actabotanica.org 1 fact
claimOcimum sanctum Linn contains phytochemicals and exhibits various biological activities, according to a 2011 overview.
An ethnobotanical study on wild edible plants in Taishan County ... frontiersin.org Jul 10, 2025 1 fact
referenceNde A. L. et al. (2022) published 'Ethnobotanical, phytochemical, toxicology and anti-diabetic potential of Senna occidentalis (L.) link; a review' in the Journal of Ethnopharmacology, volume 283.
Medicinal Plants and Traditional Uses and Modern Applications jneonatalsurg.com Mar 17, 2025 1 fact
referenceGhosh and Ray (2020) published an overview titled 'Phytochemicals and bioactive compounds from medicinal plants: An overview' in Medicinal Chemistry Research.