concept

Vitex negundo L.

Also known as: Vitex negundo, Vitex Negundo, Vitex negundo Linn., Vitex negundo cannabifolia

Facts (43)

Sources

Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 31 facts

measurement(3S,5R,10S)-3-[(β-D-glucopyranosyl)oxy]-labd-8,13-dien-16,15-olide and (3S,5R,10S)-3-hydroxy-labd-8,13-dien-16,15-olide from Vitex negundo Linn. inhibit LPS-induced NO production, with the former compound acting as the strongest inhibitor with an IC50 value of 15.8 ± 1.38 µm, and both compounds significantly inhibiting IL-1β and IL-6 levels.

claimAntioxidant lignans have been identified in the seeds of Vitex negundo cannabifolia.

measurementCasticin found in Vitex negundo Linn. has the chemical formula C19H18O8, a molecular weight of 374.3, and the identifier 5315263.

claimVitex Negundo perturbs cancer-signaling pathways involving p38, p-ERK1/2, p-JNK, N-Terminal Kinase (JNK), COX-1, MAPK, tumor necrosis factor, vascular endothelial growth factor, and hypoxia-inducible factor in LPS-stimulated cells.

claimPhytosterol and p-hydroxybenzoic acid have been isolated from the bark of Vitex negundo Linn. and identified from methanol and hexane extracts.

claimThe roots of Vitex negundo Linn. contain a furanoeremophilane.

claimVitex Negundo modulates biological processes including apoptosis, cell cycle, sperm motility, polycystic ovary disease, and menstruation.

claimSathiamoorthy et al. (2007) isolated a new antifungal flavonoid glycoside from Vitex negundo.

measurementVanillic acid found in Vitex negundo Linn. has the chemical formula C8H8O4, a molecular weight of 168.15, and the identifier 8468.

claimBioactive compounds extracted from Vitex Negundo possess anti-inflammatory, antioxidant, antidiabetic, anticancer, and antimicrobial properties.

measurementBetulinic acid found in Vitex negundo Linn. has the chemical formula C30H48O3, a molecular weight of 456.7, and the identifier 64971.

referenceGautam LM, Shrestha SL, Wagle P, and Tamrakar BM (2008) identified chemical constituents from Vitex negundo (Linn.) of Nepalese origin in the journal Scientific World.

referenceNeha B, Jannavi R, and Sukumaran P (2021) reviewed the phyto-pharmacological and biological aspects of the medicinal plant Vitex negundo in the journal Cardiovasc Dis.

claimVitex negundo Linn. is used to treat leprosy, dyspepsia, colic, rheumatism, worms, and boils.

claimPhyto-compounds from Vitex negundo, specifically oleanolic acid, ursolic acid, 3b-acetoxyolean-12-en-27-oic acid, and isovitexin, interact with the PLpro via hydrogen bonds, making them potential drug molecules for treating SARS-CoV-2.

referenceSingh et al. (2011) provided a phytopharmacological review of Vitex negundo (Sambhalu).

claimThe seeds of Vitex negundo Linn. contain two phenylnaphthalene-type lignans identified as 6-hydroxy-4-(4-hydroxy-3-methoxy-phenyl)-3-hydroxy-methyl-7-methoxy-3, 4-dihydro-2-naphthaldehyde and vitedoamine A.

measurementLuteolin found in Vitex negundo Linn. has the chemical formula C15H10O6, a molecular weight of 286.24, and the identifier 5280445.

claimSichaem et al. (2021) identified a new labdane-type diterpenoid from the leaves of Vitex negundo.

measurementLinalool found in Vitex negundo Linn. has the chemical formula C10H18O, a molecular weight of 154.25, and the identifier 6549.

measurementNishindacin A and Isonishindacin A from Vitex negundo Linn. show weak radical-scavenging effects on stable free radicals, with scavenging activity percentages of 27.14% and 25.80%, respectively.

measurementLeucoanthocyanidin found in Vitex negundo Linn. has the chemical formula C15H14O8, a molecular weight of 322.27, and the identifier 3081374.

referenceMitra et al. conducted molecular docking and simulation studies of natural compounds found in Vitex negundo L. in 2022.

claimNegundoside, Agnuside, and Vitegnoside are present in the methanolic extract of Vitex negundo leaves.

claimMethanol extracts of Vitex negundo Linn. roots contain lignins that inhibit tyrosinase.

referenceKoirala N, Dhakal C, Munankarmi NN, Ali SW, and Hameed A (2020) analyzed the phytochemical composition, nutritional content, and antioxidant and antimicrobial activity of Vitex negundo L. in the journal Cellular and Molecular Biology.

referenceKhan MF, Arora P, and Dhobi M (2021) published a prospective review on the phyto-pharmacological aspects of the medicinal plant Vitex negundo in the journal Current Traditional Medicine.

claimVitex Negundo, also known as the chaste tree, contains bioactive compounds including volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids in its leaves, seeds, and roots.

claimThe most common flavonoid glycosides found in the ethanolic extract of Vitex negundo leaves are 5-hydroxy-3, 6, 7-trimethoxy-2-(3, 4-dimtoxypheny)-4H-chrome-4-on and 5, 7-dihydroxy-2-(3, 4-dihydroxyphenyl)-4H-chromen4-one.

claimA flavonoid compound isolated from Vitex negundo leaves demonstrates inhibition efficiency against the cattle-endosymbiont Setaria cervi, suggesting potential as a phytomedicine for lymphatic filariasis.

measurementIridoid glycosides 19–20 found in Vitex negundo Linn. exhibit antioxidant effects with IC50 values greater than 20 µm.

Investigation of nutritional and phytochemical properties of wild ... nature.com Nature Dec 9, 2025 12 facts

claimThe quantitative analysis of Achyranthes aspera L. leaves, Berberis lycium Royle roots, and Vitex negundo L. leaves was performed using UPLC-PDA, which confirmed the presence of polyphenols and flavonoids in their methanolic extracts.

measurementIn a study of wild edible plants, Vitex negundo L. had the highest crude fat content at 6.601 ± 0.676, while Aegle marmelos (L.) Correa had the lowest at 0.827 ± 0.344.

claimResearchers collected leaf and root samples of ten plant species—Achyranthes aspera L., Aegle marmelos (L.) Correa, Azadirachta indica A. Juss., Berberis lycium Royle, Cassia fistula L., Senna tora (L.) Roxb, Senegalia catechu (L.f.) P.J.H.Hurter & Mobb., Syzygium cumini (L.) Skeels, Tinospora cordifolia (Willd.) Hook.f. & Thomson, and Vitex negundo L.—from sanctuary areas in the Sirmaur district of Himachal Pradesh.

claimLeaf extract of Vitex negundo L. is applied to the skin to relieve muscle aches and joint pains.

measurementProtocatechuic acid was detected at a concentration of 4.156 µg/10 mg in the plant Vitex negundo.

measurementMoisture content in sampled plants was highest in Vitex negundo L. (14.803 ± 1.153) and lowest in Senna tora (L.) Roxb. (4.303 ± 0.867).

claimThe ten wild medicinal plant species studied in the Renukaji Wildlife Sanctuary are Achyranthes aspera L., Aegle marmelos (L.) Correa, Azadirachta indica A. Juss., Berberis lycium Royle, Cassia fistula L., Senegalia catechu (L.f.) P.J.H. Hurter & Mabb., Senna tora (L.) Roxb., Syzygium cumini (L.) Skeels, Tinospora cordifolia (Willd.) Hook.f. & Thomson, and Vitex negundo L.

measurementIn a study of wild edible plants, Senna tora (L.) Roxb. had the highest crude fiber content at 17.343 ± 0.763, while Vitex negundo L. had the lowest at 5.399 ± 0.524.

claimResearchers analyzed the medicinal plants Achyranthes aspera L., Berberis lycium Royle, and Vitex negundo L. gathered from the Renukaji Wildlife Sanctuary in Sirmaur for polyphenols and flavonoids using the UPLC-PDA method (Waters Acquity UPLC H-class).

claimVanillic acid was detected in the plant Vitex negundo, although the concentration was not quantified.

measurementUPLC analysis of the methanolic leaf extract of Vitex negundo L. collected from Wildlife Sanctuaries identified the presence of Protocatechuic acid (4.156 µg/10 mg), while Vanillic acid was present but not quantified.

claimBerberis lycium Royle, Ahyranthes aspera L., and Vitex negundo L. were selected for quantitative analysis because they are widely available and frequently used by local communities for medicinal purposes.