concept

default mode network

Also known as: DMN, default mode networks

synthesized from dimensions

The Default Mode Network (DMN) is a foundational, large-scale brain network characterized by a structural and functional core that links major cortical hubs, including the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), precuneus, and inferior parietal lobule Raichle on DMN core. While some models emphasize the cortical architecture, others highlight the integration of limbic and thalamic connections primarily involving thalamus, PCC, mPFC, limbic connections. This network serves as a structural core that facilitates cortico-cortical communication and acts as a "gateway" within the brain's global synergistic workspace, contrasting with the "broadcaster" role of the executive control or frontoparietal network (FPN) DMN as workspace gateways.

Functionally, the DMN is primarily associated with self-referential processing, autobiographical memory, and social cognition DMN role in self/social cognition. It is most active during resting states or internally directed thought and is characteristically inhibited during intensive, goal-oriented tasks that require external focus DMN silenced in goal tasks. The network's expansion is thought to be tied to human-accelerated (HAR) genes, suggesting it plays a significant role in the evolution of human neocortical innovation DMN-HAR genes association.

A significant body of research demonstrates that the DMN is highly sensitive to alterations in consciousness. Psychedelics such as psilocybin, LSD, and ayahuasca consistently reduce DMN integrity, functional connectivity, and oscillatory power psychedelics reduce DMN integrity. This dampening of DMN activity—particularly in the PCC and mPFC—is associated with the liberation of bottom-up sensory flow liberates bottom-up flow, which facilitates ego-dissolution, enhanced cognitive flexibility, and mystical or ineffable experiences compromised DMN boosts flexibility.

Similar patterns of DMN disruption are observed in other states of altered consciousness, including meditation, hypnosis, and epilepsy DMN disruption in consciousness changes. During meditation, for instance, reduced activity in DMN nodes correlates with states of concentration and choiceless awareness Brewer et al. (2011). In these states, the destabilization of top-down dynamics—often involving the compromise of DMN-PFC connectivity—appears to be a unified mechanism that allows for the emergence of alternative cognitive or perceptual modes destabilizing top-down dynamics.

The significance of the DMN lies in its role as a regulator of the balance between internal reflection and external engagement. When the network is interrupted, whether through task-based inhibition, pharmacological intervention, or meditative practice, the brain's capacity for self-referential narrative is diminished, often leading to broadened sensory content and increased cognitive plasticity. The DMN thus serves as a critical nexus for maintaining the continuity of the self, and its modulation is central to understanding both standard human cognition and profound shifts in conscious experience.

Model Perspectives (2)

openrouter/x-ai/grok-4.1-fast definitive 95% confidence

The Default Mode Network (DMN) is a core brain network involving key hubs such as the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC)/precuneus, inferior parietal lobule, and lateral parietal cortex, forming a structural core that links major brain hubs via cortico-cortical pathways, according to Raichle (2015) Raichle on DMN core and detailed subdivisions DMN major subdivisions. It supports self-referential processing, social cognition DMN role in self/social cognition, autobiographical memory, and creative problem-solving, where its activity correlates with external challenges and interruptions reduce abilities, per Shofty et al. (2022) and Bartoli et al. (2024) DMN interruptions reduce creativity. DMN activity is inhibited during intensive goal-oriented tasks DMN silenced in goal tasks and serves as 'gateways' in the global synergistic workspace, contrasting with 'broadcasters' in the executive control/frontoparietal network (FPN), as shown in Human Connectome Project data DMN as workspace gateways. Psychedelics like LSD, psilocybin, and ayahuasca consistently reduce DMN integrity, functional connectivity (e.g., between mPFC/PCC and parahippocampus/retrosplenial cortex), and oscillatory power psychedelics reduce DMN integrity, per Alonso et al. (2015) Alonso et al. on psychedelics DMN, Carhart-Harris et al. (2012, 2016) Carhart-Harris psychedelics DMN, and Palhano-Fontes et al. (2015) ayahuasca modulates DMN, leading to ego-dissolution, enhanced cognitive flexibility, ineffability, and broadened sensory/mnemonic content compromised DMN boosts flexibility. Similar DMN disruptions occur in meditation meditation alters DMN, epilepsy seizures impair DMN nodes, and other consciousness alterations DMN disruption in consciousness changes, often correlating with ego-loss or visionary states, as in Barrett and Griffiths (2017) psychedelic-meditative DMN parallels. Evolutionarily, DMN expansion ties to human-accelerated genes (HAR genes) and neocortical innovation DMN-HAR genes association. Variations in psychedelic effects on DMN stem from dosage, phase, and administration, per Dos Santos et al. (2016) variations in DMN effects.

openrouter/x-ai/grok-4.1-fast 90% confidence

The default mode network (DMN) is a brain network primarily involving thalamus, PCC, mPFC, limbic connections for information routing and integration, according to Buckner et al. (2008), with anterior connectivity between dorsal/ventral mPFC and ACC described by Washington and VanMeter (2015) mPFC-ACC connectivity. Raichle (2015) offered a comprehensive overview Raichle overview in the Annual Review of Neuroscience. The DMN supports self-referencing and top-down control processes, often linked to prefrontal cortex (PFC) functions. Psychedelics like psilocybin and ayahuasca disrupt DMN integrity: psilocybin reduces oscillatory activity in DMN regions per Muthukumaraswamy et al. (2013), while ayahuasca decreases activity in PCC, precuneus, mPFC and connectivity, as found by Palhano-Fontes et al. (2015). This dampening liberates bottom-up flow, inhibits self-related functions causing ego dissolution, and contributes to mystical effects, with Barrett, Johnson, and Griffiths (2017) at Johns Hopkins examining psilocybin's impact on meditators' DMN connectivity. Similar DMN deactivation occurs in meditation—Brewer et al. (2011) showed reduced activity in DMN nodes during concentration, loving-kindness, and choiceless awareness—and hypnosis, where anterior DMN reduction correlates with depth per McGeown et al. (2009) and Deeley et al. (2012). These states, including epilepsy, compromise DMN-PFC connectivity, destabilizing top-down dynamics and enabling bottom-up processes or mirror neuron overlaps per Molnar-Szakacs and Uddin (2013), suggesting a unified mechanism for altered consciousness via DMN interruption, particularly PCC.

Facts (103)

Sources

The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Frontiers Sep 27, 2017 51 facts

claimAlonso et al. (2015) reported that psychedelics reduce Default Mode Network (DMN) integrity and cause disintegration in normal system functions by reducing connectivity between the frontal cortex and lower brain areas.

claimPsychedelic experiences do not typically manifest operators that depend on higher-level cognitive integration provided by the prefrontal cortex (PFC) or the self and autobiographical qualities maintained by the Default Mode Network (DMN).

claimSpeech production is compromised under LSD because of the lack of connections with the neocortical components involving the frontal lobe (Broca's area), while the language capacity for understanding meaning persists because of its lower anatomical basis near the Default Mode Network (DMN) component, the inferior parietal lobule in the superior temporal gyrus (Wernicke's area).

referenceUddin et al. published 'Functional connectivity of default mode network components: correlation, anticorrelation, and causality' in Human Brain Mapping in 2009 (Hum. Brain Mapp. 30, 625–637).

referenceBarrett and Griffiths (2017) identified parallels in the neural bases of psychedelic and meditative effects on the Default Mode Network (DMN), specifically hypothesizing that visionary experiences result from decreased activity and functional connectivity in the medial nodes of the DMN (PCC and MPFC), which mediate self-referential processing.

referenceRaichle (2015) concluded that the cortico-cortical axonal pathways involve a structural core comprised of the posterior medial cortex and parietal cerebral cortex, as well as the temporal and frontal modules that link all major structural hubs of the brain through the posterior areas of the Default Mode Network.

referenceThe hypothesis that innate operators explain features of psychedelic experiences is supported by evidence of innate modular functions in entoptic images (Siegel, 1977), the modular structure of the human brain (Gardner, 1983, 2000), cognitive science of religion explanations for supernatural experiences (Boyer, 2001, 2017; Clements, 2017), and the relationship of the MNS (Mirror Neuron System) to the DMN (Default Mode Network) and mimesis (Garrels, 2006, 2011).

claimVisionary experiences across diverse modes of altering consciousness share a common mechanism released by the interruption of the prefrontal cortex (PFC) and the default mode network (DMN).

referenceThe Default Mode Network is functionally and anatomically connected with the thalamus and precuneus, a connectivity that is crucial to consciousness, according to Cunningham et al. (2017).

claimDos Santos et al. (2016) noted that variations in study results regarding psychedelic effects on the Default Mode Network may be attributed to differences in the phase of the experience studied, drug dosage, measurement time-scales, and the route of administration (oral vs. intravenous).

claimThe common mechanisms underlying diverse alterations of consciousness involve the disruption of normal functions in the prefrontal cortex and the default mode network (DMN).

claimThe activation or disinhibition of areas within the dorsal medial subsystem of the Default Mode Network (DMN), which manages social information, is implicated in the high importance of a social 'other' in some mystical experiences.

claimPsychedelic use results in reduced functional connectivity among areas of the Default Mode Network.

claimPsychedelics and other processes that alter consciousness share common mechanisms involving the disabling of the prefrontal cortex and default mode networks.

claimThe neural correlates of out-of-body experiences involve a disruption of a specific Default Mode Network (DMN) area, the temporo-parietal junction (TPJ), which integrates bodily and sensory modalities.

referenceThe anterior cingulate cortex (ACC) provides a locus for the interaction between the default mode network (DMN) and the mirror neuron system (MNS), as reported by Uddin et al. (2007).

claimDisruption of the Default Mode Network (DMN) may account for the frequently reported sense of ineffability, defined as the inability to express the psychedelic experience in words.

claimEgoless experiences, measured as 'oceanic boundlessness,' are associated with alterations in the frontolimbic-parieto-striatal network and are positively correlated with cerebral glucose metabolism in Default Mode Network regions (anterior cingulate cortex, hippocampus, inferior parietal cortex) and prefrontal cortex areas (frontomedial superior, frontolateral, and left inferolateral).

claimEpileptic seizures, including complex partial, generalized tonic-clonic, and absence seizures, impair primary nodes of the Default Mode Network (DMN), specifically the precuneus/PCC, medial frontal cortex, lateral parietal cortex, and the anterior cingulate cortex (ACC), resulting in long-lasting decreases in DMN activity.

claimReduced activity and connectivity within the Default Mode Network (DMN) are observed in both psychedelic use and various non-pharmacological methods for altering consciousness.

claimDecreased integrity of the Default Mode Network is reflected by decreased functional connectivity between the parahippocampus and retrosplenial cortex, the magnitude of which is strongly correlated with self-report ratings of spiritual experience and ego-dissolution, according to Kometer et al. (2013), Lebedev et al. (2015), Carhart-Harris et al. (2016), and Tagliazucchi et al. (2016).

claimThe reduction in oscillatory activity and power in the Default Mode Network caused by psilocybin results from decreased functional coupling between the frontal cortex and the medial temporal lobe components of the Default Mode Network, as well as between the medial prefrontal cortex and the posterior cingulate cortex.

referenceThe 2016 review by dos Santos et al. reported a decrease in functional connectivity between key hubs of the Default Mode Network (DMN), specifically noting a reduction in connectivity between the posterior cingulate cortex (PCC) and the anterior cingulate cortex (ACC).

referenceThe paper 'Internal and external attention and the default mode network' by H. Scheibnera, C. Bogler, T. Gleich, C.J.-D. Haynes, and F. Bermpohla, published in NeuroImage in 2017, discusses the default mode network's role in attention.

referenceBrewer et al. (2011) found that meditation experience is associated with differences in default mode network activity and connectivity, as published in the Proceedings of the National Academy of Sciences of the United States of America.

referenceThe mirror neuron system (MNS) and the medial prefrontal cortex (mPFC) node of the default mode network (DMN) interact significantly during mentalizing and embodied simulation processes, according to Molnar-Szakacs and Uddin (2013).

claimPositive emotional experiences and profound quiescence of meditative practices result from a deafferentation of limbic stimulation from the peripheral parasympathetic system, combined with reverberating parietal lobule connections with Prefrontal Cortex (PFC) circuits that result in stimulation of both divisions of the Autonomic Nervous System and enhanced connections of the sensory association areas with the inferior parietal lobe, a key Default Mode Network (DMN) area.

referenceHigh-hypnotizability subjects exhibit greater decreases in Default Mode Network (DMN) activity, particularly in the dorsal anterior cingulate cortex (ACC), and reduced connectivity between the posterior cingulate cortex (PCC) and the Executive Control Network, according to a 2017 study by Jiang et al.

claimPsychedelics cause reduced activity in the Default Mode Network's hub structures, which leads to a reduction in oscillatory activity and network integrity, as documented by Carhart-Harris et al. (2012, 2016), Muthukumaraswamy et al. (2013), and Palhano-Fontes et al. (2015).

claimPalhano-Fontes et al. (2015) found that the psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network in the human brain.

referenceWashington and VanMeter published 'Anterior-posterior connectivity within the default mode network increases during maturation' in the International Journal of Medical and Biological Frontiers in 2015 (Int. J. Med. Biol. Front. 21, 207–218).

claimPanda et al. (2016) found that temporal dynamics of the default mode network characterize meditation-induced alterations in consciousness.

claimThe "meaning" network involved in understanding verbal and visual events overlaps with major areas of the Default Mode Network (DMN) and involves brain areas recognized for their role in semantic memory, embodied simulation, and visuo-spatial scene representation, according to Jouena et al. (2015).

referenceA 2016 study by Panda et al. using EEG and fMRI compared 20 Raja Yoga expert meditators to a control group and found that meditators had significant reductions in activity and connectivity of the posterior cingulate hub of the Default Mode Network.

referenceThe major subdivisions of the Default Mode Network include the ventral medial and dorsal medial regions of the prefrontal cortex, the posterior cingulate cortex (PCC) with the precuneus, and the lateral parietal cortex.

referenceThe Default Mode Network (DMN) is based in the medial and lateral cortices of the parietal and temporal lobes, as well as the medial prefrontal cortex (mPFC), according to Raichle (2015).

claimPsychedelics increase functional connectivity between normally disconnected brain networks, which contrasts with their acute effect of reducing functional connectivity within the Default Mode Network.

referenceRaichle (2015) provided an overview of the brain's default mode network in the 'Annual Review of Neuroscience'.

claimThe psychedelic-induced disruption of Default Mode Network (DMN) self-related functions likely causes the changes in the experience of self and the relationship to a spiritual 'other' typical of personalized theistic mystical experiences.

claimThe disruption of top-down control mediated by the prefrontal cortex (PFC) and the compromise of self-referencing processes in the default mode network (DMN) leads to the emergence of processes from lower-level brain systems, which manifest as innate intelligences, modules, and operators.

referenceThe major types of meditation techniques, specifically Concentration, Loving-Kindness, and Choiceless Awareness, produce a relative deactivation in the main nodes of the Default Mode Network (DMN) in experienced meditators, according to a 2011 study by Brewera et al.

claimPsychedelic-induced mystical effects are partly the result of inhibiting the normal functions of the Default Mode Network (DMN).

referencePalhano-Fontes et al. (2015) found that ayahuasca consumption causes a significant decrease in activity throughout most parts of the Default Mode Network, particularly in the posterior cingulate cortex, precuneus, and medial prefrontal cortex, while also reducing functional connectivity within the posterior cingulate cortex/precuneus.

claimThe interruption of the Default Mode Network (specifically the posterior cingulate cortex) by meditation, hypnosis, and epilepsy necessitates a general explanation for psychedelic effects within the broader context of altered consciousness.

referenceWashington and VanMeter (2015) characterized the connectivity between the dorsal and ventral regions of the medial prefrontal cortex (mPFC) and the dorsal and ventral areas of the anterior cingulate cortex (ACC) as the most anterior area of functional connectivity within the default mode network (DMN).

referenceThe Default Mode Network primarily involves connections among the thalamus, posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), and areas of the limbic system (parahippocampal cortex and the hippocampus) that function as a network for information routing and integration, as described by Buckner et al. (2008).

claimPsychedelics, meditation, hypnosis, and epilepsy all cause an interruption of ordinary brain control processes by compromising the integrity of the Default Mode Network (DMN) and its connectivity with other brain areas, particularly the prefrontal cortex (PFC).

claimThe Default Mode Network (DMN) connection with the Mirror Neuron System (MNS) is stimulated by increased activation of right fronto-parietal regions, which overlap with MNS areas involved in mapping the actions of others via simulation within one's own motor system, according to Molnar-Szakacs and Uddin (2013).

measurementMuthukumaraswamy et al. (2013) found that psilocybin caused a reduction in oscillatory activity and power in posterior and frontal association cortices and the Default Mode Network.

claimDestabilization of habitual cognitive mechanisms, specifically the Default Mode Network, reduces top-down brain dynamics and facilitates bottom-up information transfer.

referenceHypnosis reduces activity in the anterior areas of the Default Mode Network (DMN), with the depth of attentional absorption induced by hypnosis correlating with the degree of DMN activity reduction, according to studies by McGeown et al. (2009) and Deeley et al. (2012).

A Synergistic Workspace for Human Consciousness Revealed by ... elifesciences.org eLife 18 facts

claimGateways in the brain reside primarily in the default mode network, while broadcasters are mainly located in the executive control network, specifically the lateral prefrontal cortex.

claimFunctional MRI analysis reveals that gateway regions of the synergistic global workspace correspond to the brain’s default mode network, while broadcaster regions coincide with the executive control network.

claimResults from the Human Connectome Project (HCP) dataset indicate that workspace gateways correspond to the brain’s default mode network (DMN) and workspace broadcasters correspond to the executive control network (FPN).

referenceShanahan hypothesized that the Frontoparietal Network (FPN) and Default Mode Network (DMN) tandem functions as a 'connective core' along the brain's medial axis to support consciousness.

claimRegions showing consistent decreases in ΦR during loss of consciousness were primarily members of the global synergistic workspace, specifically the default mode network (bilateral precuneus and medial prefrontal cortex) and bilateral inferior parietal cortex, with involvement of left temporal cortices.

referenceThe paper 'Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients' by Vanhaudenhuyse et al. (2010) establishes that connectivity within the default mode network correlates with the level of consciousness in patients with brain damage who cannot communicate.

referenceThe paper 'Situating the default-mode network along a principal gradient of macroscale cortical organization' was published in the Proceedings of the National Academy of Sciences of the United States of America (113:12574–12579).

claimThe breakdown of Default Mode Network (DMN) connectivity within the synergistic workspace is associated with a failure to integrate an individual's self-narrative into the stream of consciousness, a concept originally described by William James.

claimThe default mode network (DMN) occupies a position at the convergence of functional gradients of macroscale cortical organization and forms a structural and functional core of the human brain.

claimThe Default Mode Network (DMN) exhibits compromised information content and integrative capacity during loss of consciousness induced by anesthesia, severe brain injury, and COVID-19.

claimThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' identify Default Mode Network (DMN) nodes as gateways for inputs to the synergistic global workspace.

claimThe default mode network (DMN) comprises the posterior cingulate, precuneus, medial prefrontal cortex, and inferior parietal cortices.

claimThe posterior regions of the default mode network (DMN) act as relays between the neocortex and the hippocampal memory system.

claimThe default mode network (DMN) is involved in self-referential processing, mental-time-travel, episodic memory, and future-oriented cognition.

claimThe reliance on 'resting-state' data without external stimuli may have resulted in an overestimation of the Default Mode Network's (DMN) role in consciousness and an under-estimation of the Frontoparietal Network (FPN), including the lateral prefrontal cortex, due to their different recruitment during no-task conditions.

claimThe Default Mode Network (DMN) is positioned to integrate and contextualize sensory information into the synergistic global workspace by combining it with past experiences and mental models of the self and world.

claimThe loss of consciousness across anaesthesia and disorders of consciousness corresponds to anterior-posterior disconnection between default mode network nodes that act as gateways into the synergistic workspace.

claimReductions in integrated information (ΦR) associated with the loss of consciousness occur specifically within the default mode network.

The evolution of human-type consciousness – a by-product of ... frontiersin.org Frontiers 14 facts

referenceInterruptions to the default mode network reduce creative problem-solving ability (Shofty et al., 2022; Bartoli et al., 2024).

perspectiveThe author hypothesizes that innovation is the survival benefit that promoted the evolution of the neocortex, specifically the default mode network and its chaotic activity.

perspectiveThe noisy activity of the default mode network is hypothesized to be a 'feature' (the primary reason for neocortex evolution) rather than a 'bug' (an excess or side effect), given its role in creative problem-solving.

referenceBartoli et al. (2024) published 'Default mode network electrophysiological dynamics and causal role in creative thinking' in Brain, volume 147, pages 3409–3425.

referenceDefault mode network activity positively correlates with external challenges during creative problem-solving, with activity peaks observed before solutions emerge (Broday-Dvir and Malach, 2021).

claimWhen intensive, goal-oriented action is required, the activity of the default mode network is inhibited and silenced.

claimThe default mode network is characterized by almost nonstop activity that lacks a visible relation to specific operational needs or external messages, which is similar to the incessant stream of thoughts associated with consciousness.

claimMany mammals possess similar innovation systems with similar interfaces because they share neural structures such as the neocortex, the claustrum (excluding monotremes), and the default mode network.

claimThe default mode network is involved in consciousness, according to scholarly consensus (Raichle, 2015).

referenceShofty et al. (2022) published 'The default network is causally linked to creative thinking' in Molecular Psychiatry, presenting evidence for the role of the default mode network in creativity.

claimDefault mode network activity subsides when brain resources are mobilized for demanding challenges.

referenceThe default mode network consumes a significant portion of neocortical activity, operates almost continuously, and its intensity is generally inversely proportional to concrete task performance (Raichle et al., 2001; Menon, 2023).

referenceRaichle et al. (2001) published 'A default mode of brain function' in the Proceedings of the National Academy of Sciences, which established the concept of the default mode network.

referenceMenon (2023) published '20 years of the default mode network: a review and synthesis' in Neuron, providing an overview of the default mode network's research history.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 9 facts

claimThe alteration of distributed neural processes by psychedelics manifests as increased synaptic plasticity and entropy, reduced integrity of discrete brain networks (such as the functional disintegration of the default-mode network), and reduced segregation between networks (such as increased functional connectivity between the default-mode network and the dorsal attention network).

claimThe degradation of the brain's ability to impose habitual organization during psychedelic states involves a temporal disabling of the Default Mode Network (DMN), which decreases top-down inhibition and liberates bottom-up information flow from sources like the limbic system.

claimCompromised default-mode network (DMN) function, induced by psychedelics, leads to an inhibition or reduction of personhood and agency, resulting in enhanced cognitive flexibility and emotional lability.

claimPsychedelics functionally modulate the activity and connectivity of the frontoparietal network and the Default Mode Network (DMN), which can enhance cognitive functioning and sociality, according to research by Carhart-Harris and Friston (2019), Vollenweider and Preller (2020), Cini et al. (2019), and Preller and Vollenweider (2019).

claimRapid evolutionary cortical expansion and reorganization in the human brain is most pronounced in higher-order cognitive networks, specifically the frontoparietal network and the Default Mode Network (DMN), and runs parallel with high expression of human-accelerated genes (HAR genes) involved in synapse and dendrite formation, according to Wei et al. (2019).

claimThe disabling of the Default Mode Network during psychedelic states broadens the volume and breadth of sensory and mnemonic content, increasing the potential for novel insights and perspectives.

claimHuman-accelerated genes (HAR genes) and Default Mode Network (DMN) genes show significant associations with individual variations in DMN functional activity, intelligence, social behavior, and mental conditions such as schizophrenia and autism, according to Wei et al. (2019).

claimThe default-mode network (DMN) plays a role in self and social cognition.

claimPsychedelics exert a temporal dampening effect on the activity and integrity of the default-mode network (DMN), which decreases top-down inhibition and liberates sensory and cognitive bottom-up information flow, thereby increasing the richness of subjective experience.

Self-awareness, self-regulation, and self-transcendence (S-ART) frontiersin.org Frontiers in Human Neuroscience 3 facts

referenceTaylor et al. (2012) studied the impact of meditation training on the default mode network during a restful state, as published in Social Cognitive and Affective Neuroscience.

referenceJ. H. Jang, W. H. Jung, D. H. Kang, M. S. Byun, S. J. Kwon, C. H. Choi, et al. published a 2010 study in Neuroscience Letters finding that increased default mode network connectivity is associated with meditation.

referenceOtt et al. (2010b) reported on the inhibition of default mode network activity during mindfulness meditation.

Adversarial testing of global neuronal workspace and ... - Nature nature.com Nature Apr 30, 2025 1 fact

referenceThe article 'Fragmentation and multithreading of experience in the default-mode network' published in Nature Communications in 2025 cites the Nature article 'Adversarial testing of global neuronal workspace and integrated information theories of consciousness'.

The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org Frontiers in Psychiatry 1 fact

referenceEvans et al. (2018) measured default mode connectivity in patients with major depressive disorder up to 10 days following the administration of ketamine, as published in Biological Psychiatry.

Ancient Roots of Today's Emerging Renaissance in ... link.springer.com Springer 1 fact

claimClassic psychedelics initiate a cascade of altered neural connectivity and blood-flow across brain regions including the default-mode network (medial prefrontal cortex, posterior cingulate cortex, inferior parietal lobule, lateral temporal cortex, hippocampus, and precuneus), the amygdala, the thalamus, and the claustrum.

Resting State Networks and Consciousness - PMC - NIH pmc.ncbi.nlm.nih.gov PMC 1 fact

claimFunctional magnetic resonance imaging (fMRI) resting state studies demonstrate that Default Mode Network (DMN) connectivity is reduced during altered states of consciousness, including sleep, sedation, anesthesia, and hypnotic states.

Altered states of consciousness – Knowledge and References taylorandfrancis.com Raquel Consul, Flávia Lucas, Maria Graça Campos · Taylor & Francis 1 fact

claimHypnosis is associated with decreased default mode network activity in the brain, and high hypnotizability correlates with increased functional connectivity between the executive control network and the salience network.

Understanding LLM Understanding skywritingspress.ca Skywritings Press Jun 14, 2024 1 fact

referenceJ. Smallwood, B. C. Bernhardt, R. Leech, D. Bzdok, E. Jefferies, and D. S. Margulies published 'The default mode network in cognition: a topographical perspective' in Nature Reviews Neuroscience in 2021.

Disruption of thalamic functional connectivity is a neural correlate of ... pmc.ncbi.nlm.nih.gov PMC 1 fact

claimUnconsciousness is associated with decreased thalamic cerebral metabolic rate of glucose (CMRglc), regional cerebral blood flow (rCBF), and functional connectivity to the Default Mode Network (DMN), according to the study 'Disruption of thalamic functional connectivity is a neural correlate of...'.

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 1 fact

referenceA 2017 study by Barrett, Johnson, and Griffiths published in Drug and Alcohol Dependence examined the effects of psilocybin on long-term meditators, specifically regarding default mode network functional connectivity and retrospective ratings of qualitative experience.