Knowledge Tree
psychedelic effects
Also known as: psychedelic properties
Facts (17)
Sources
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Sep 27, 2017 6 facts
claimCorticothalamic networks are implicated in both epileptic seizures and psychedelic effects.
referenceBarrett and Griffiths (2017) identified parallels in the neural bases of psychedelic and meditative effects on the Default Mode Network (DMN), specifically hypothesizing that visionary experiences result from decreased activity and functional connectivity in the medial nodes of the DMN (PCC and MPFC), which mediate self-referential processing.
claimDos Santos et al. (2016) noted that variations in study results regarding psychedelic effects on the Default Mode Network may be attributed to differences in the phase of the experience studied, drug dosage, measurement time-scales, and the route of administration (oral vs. intravenous).
claimPsychedelic effects enhance the primary social functions of rituals by tuning interpersonal dynamics.
claimThe worldwide distribution and cultural use of psilocybin-containing mushrooms attest to the inevitability of psychedelic effects on human evolution.
claimThe interruption of the Default Mode Network (specifically the posterior cingulate cortex) by meditation, hypnosis, and epilepsy necessitates a general explanation for psychedelic effects within the broader context of altered consciousness.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 5 facts
referenceA 2024 study in 'Drug and Alcohol Dependence' found that acute psychedelic effects and clinical outcomes are associated with the therapeutic alliance among participants receiving psilocybin therapy.
referenceDavis, A. K., Xin, Y., Sepeda, N. D., Garcia-Romeu, A., and Williams, M. T. published 'Increases in Psychological Flexibility Mediate Relationship Between Acute Psychedelic Effects and Decreases in Racial Trauma Symptoms Among People of Color' in the journal Chronic Stress in 2021.
referenceThe study 'Cognitive control as a transdiagnostic mechanism of action in psychedelic effects' was published in Cognitive, Affective, & Behavioral Neuroscience in 2025 by Sayalı, C., Truesdale, A., and Rosen, D.S.
referenceA 2020 study by Davis, Barrett, and Griffiths determined that psychological flexibility mediates the relationship between acute psychedelic effects and subjective decreases in depression and anxiety.
referenceA 2023 literature review published in the 'Journal of Psychopharmacology' examined the psychedelic effects of cannabis.
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 3 facts
procedureResearchers propose using combined Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) methods, specifically using the 5-HT2A-selective ligand [11 C]Cimbi-36, to create a 'molecular-functional-clinical bridge' in understanding psychedelic effects.
claimThe use of neuroimaging in clinical trials provides scientific results, informs theories of psychedelic effects, and produces visually-arresting results that are reproduced in mainstream media.
claimTesting the relationship between network-disintegration observed in acute fMRI studies and longer-term measures of neuroplasticity, emotional function, or other post-dosing changes is considered a crucial test of current theories regarding psychedelic effects.
History and Current Status of Psychedelics and Entactogens ... - NCBI ncbi.nlm.nih.gov 1 fact
accountR. Gordon Wasson published an account of his experience with 'magic mushrooms' in Life magazine in 1957, which marked the first report of the mushrooms' psychedelic properties.
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 1 fact
referenceThe article 'A unified model of ketamine’s dissociative and psychedelic properties' by Marguilho et al. was published in the Journal of Psychopharmacology in 2023.
Psychedelics, Sociality, and Human Evolution frontiersin.org 1 fact
claimPsychedelic effects can reduce symptoms of autism, as shown by Sigafoos et al. in 2007, and can mimic certain aspects of psychosis, as shown by Carhart-Harris et al. in 2016.