Pediatric studies indicate that children with sleep apnea experience elevations in systemic blood pressure during both wakefulness and sleep, as well as left ventricular wall changes detectable by echocardiography.
A 2003 study by Holmes et al. reported that vagal nerve stimulation can induce sleep apnea and excessive daytime somnolence.
Bliwise (2002) reviewed the relationship between sleep apnea, the APOE4 gene, and Alzheimer’s disease.
Bixler et al. (1998) examined the effects of age on the prevalence and severity of sleep apnea in men.
Grunstein et al. (1993) found an association between snoring and sleep apnea in men and the presence of central obesity and hypertension.
Opioids should be used cautiously in patients who snore because they may exacerbate sleep apnea, according to Montplaisir et al. (2005).
Approximately 30 percent of patients diagnosed with essential hypertension are found to have sleep apnea, according to case-control studies cited by Partinen and Hublin (2005).
A 2000 study by Redline et al. in the American Journal of Respiratory and Critical Care Medicine evaluated how different approaches for identifying respiratory disturbances affect the assessment of sleep apnea.
Javaheri S et al. studied sleep apnea in 81 ambulatory male patients with stable heart failure, documenting types, prevalences, consequences, and presentations in a 1998 Circulation article.
A 2003 study by Netzer et al. published in Chest examined the prevalence of symptoms and the risk of sleep apnea in primary care settings.
A 2004 study by Nieto et al. published in the American Journal of Respiratory and Critical Care Medicine examined the relationship between sleep apnea and markers of vascular endothelial function in a large community sample of older adults.
Restless legs syndrome (RLS), periodic limb movement disorder, sleep apnea, and excessive daytime sleepiness affect up to 70 percent of patients with end-stage renal disease receiving hemodialysis.
An observational follow-up study found that untreated sleep apnea patients (n=61) were more likely to die from cardiovascular disease compared to those treated with CPAP therapy for at least 5 years (n=107), with mortality rates of 14.8 percent versus 1.9 percent.
Vagal nerve stimulation may induce sleep apnea.
Studies of patients at sleep clinics tend to show an association between sleep apnea and mortality, according to He et al. (1988).
Nieto et al. (2000) identified an association between sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study known as the Sleep Heart Health Study.
Grunstein R., Wilcox I., Yang TS, Gould Y., and Hedner J. (1993) found an association between snoring and sleep apnea in men and central obesity and hypertension in the 'International Journal of Obesity-Related Metabolic Disorders'.
Taasan, Block, Boysen, and Wynne found that alcohol increases sleep apnea and oxygen desaturation in asymptomatic men, as published in the American Journal of Medicine in 1981.
Bliwise DL, Bliwise NG, Partinen M, Pursley AM, and Dement WC studied sleep apnea and mortality in an aged cohort, published in the American Journal of Public Health.
Punjabi and Beamer discussed sleep apnea and metabolic dysfunction in the 4th edition of 'Principles and Practice of Sleep Medicine', published by Elsevier/Saunders in 2005.
A 1990 study by Hung et al. found an association between sleep apnea and myocardial infarction in men.
Referral bias may result in a lower apparent rate of sleep apnea in females compared to males.
Netzer et al. (2003) conducted an international study in primary care settings to determine the prevalence of symptoms and the risk of sleep apnea.
Bassetti C and Aldrich MS reported on sleep apnea in 128 patients with acute cerebrovascular diseases in a 1999 study published in Sleep.
Studies of patients at sleep clinics tend to show an association between sleep apnea and mortality, but several population-based studies have failed to find this association, according to Young et al. (2002a,b), Lavie et al. (2005), He et al. (1988), Ancoli-Israel et al. (1996), Lindberg et al. (1998), and Kripke et al. (2002).
Bliwise et al. investigated the relationship between sleep apnea and mortality in an aged cohort.
Bassetti et al. (1996) conducted a prospective study of 59 patients which examined the prevalence of sleep apnea in individuals who had experienced a transient ischemic attack or stroke.
Somers, Mark, and Abboud found that hypoxia and hypercapnia cause sympathetic activation, which has implications for sleep apnea, as published in Clinical and Experimental Hypertension: Part A, Theory and Practice in 1988.
Vagal nerve stimulation has been reported to improve daytime alertness (Rizzo et al., 2003), but it may also induce sleep apnea (Holmes et al., 2003).
Sleep-disordered breathing and sleep apnea are associated with hypertension in community-based populations.
Bixler, Vgontzas, Ten Have, Tyson, and Kales studied the effects of age on the prevalence and severity of sleep apnea in men.
While studies of patients at sleep clinics tend to show an association between sleep apnea and mortality, most population-based studies have failed to find such an association, with the exception of a subgroup of patients under age 60 with both snoring and excessive daytime sleepiness, who experienced twice the risk of mortality.
Approximately 30 percent of patients diagnosed with essential hypertension turn out to have sleep apnea.
A 10-year observational study of 403 sleep apnea patients, snorers, and healthy controls found a threefold higher risk of fatal cardiovascular events in patients with severe Obstructive Sleep Apnea (OSA).
A 1993 study by Grunstein, Wilcox, Yang, Gould, and Hedner found an association between snoring and sleep apnea in men and the presence of central obesity and hypertension.
Redline et al. (2000) evaluated the effects of varying approaches for identifying respiratory disturbances on the assessment of sleep apnea.
The Sleep in Primary Care International Study Group investigated the prevalence of symptoms and the risk of sleep apnea within primary care settings.
Vgontzas A.N., Tan T.L., Bixler E.O., Martin L.F., Shubert D., and Kales A. found an association between sleep apnea and sleep disruption in obese patients, as published in the Archives of Internal Medicine in 1994.
Recent studies suggest that a referral bias may result in a lower apparent rate of sleep apnea in females than in males, as reported by Kapsimalis and Kryger (2002) and Shepertycky et al. (2005).
Bixler EO, Vgontzas AN, Ten Have T, Tyson K, and Kales A studied the effects of age on sleep apnea in men, specifically prevalence and severity, published in the American Journal of Respiratory and Critical Care Medicine in 1998.
Sleep apnea is associated with markers of vascular endothelial function in older adults.
Several population-based studies failed to find an association between sleep apnea and mortality, according to Ancoli-Israel et al. (1996), Lindberg et al. (1998), and Kripke et al. (2002).
Sleep apnea is linked to metabolic dysfunction, as discussed by Punjabi and Beamer in the 2005 edition of 'Principles and Practice of Sleep Medicine'.
The Sleep Heart Health Study, published in the Journal of the American Medical Association in 2000, found an association between sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study.
Vgontzas AN et al. studied sleep apnea and sleep disruption in obese patients, as published in the Archives of Internal Medicine in 1994.