Knowledge Tree
heart failure
Facts (24)
Sources
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 6 facts
claimPatients with impaired baroreflexes, such as those with hypertension, heart failure, or premature infants, are susceptible to excessive autonomic responses to chemoreflex stimulation during apnea, which can lead to bradyarrhythmias, hypoxia, hypoperfusion, and sympathetic activation, potentially predisposing them to sudden death.
claimSleep-disordered breathing has been found in a high frequency of individuals with transient ischemic attacks (McArdle et al., 2003), hypertension (Morrell et al., 1999), myocardial infarction, and heart failure (Good et al., 1996; Shamsuzzaman et al., 2003).
referenceBradley TD, Logan AG, Kimoff RJ, Series F, Morrison D, Ferguson K, Belenkie I, Pfeifer M, Fleetham J, Hanly P, Smilovitch M, Tomlinson G, and Floras JS published a study titled 'Continuous positive airway pressure for central sleep apnea and heart failure' in the New England Journal of Medicine in 2005 (Volume 353, Issue 19, pages 2025–2033).
referenceJavaheri S et al. studied sleep apnea in 81 ambulatory male patients with stable heart failure, documenting types, prevalences, consequences, and presentations in a 1998 Circulation article.
claimSleep-disordered breathing is found in a high frequency of individuals with myocardial infarction and heart failure.
measurementThe Sleep Heart Health Study, a cross-sectional study of nearly 6,500 participants, found that individuals in the highest apnea-hypopnea index quartile (index greater than 11) were 42 percent more likely to self-report cardiovascular disease, including coronary heart disease, heart failure, or stroke, compared to those in the lowest quartile (adjusted OR = 1.42, 95% CI, 1.13–1.78).
Stress, Lifestyle, and Health – Introduction to Psychology open.maricopa.edu 2 facts
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 2 facts
claimEndothelial dysfunction contributes to heart failure development by disrupting endothelial nitric oxide synthase (eNOS) activity, which reduces nitric oxide availability, increases reactive oxygen species production, and activates inflammatory cascades involving NF-κb signaling and the expression of adhesion molecules ICAM1 and VCAM1.
claimDigoxin, derived from foxglove (Digitalis purpurea), remains a cornerstone therapy for heart failure patients who do not respond to modern alternatives.
How sleep deprivation can harm your health - Harvard Health health.harvard.edu Jul 22, 2025 2 facts
claimSleep apnea increases the risk of heart attack, heart failure, and heart rhythm disorders such as atrial fibrillation.
claimSleep apnea causes low oxygen and high carbon dioxide levels in the blood, which raises stress hormones, blood pressure, and heart rate, and increases the risk of heart attack, heart failure, and atrial fibrillation.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 2 facts
measurementGlobally, cardiovascular disease accounts for 31% of all deaths, with coronary heart disease accounting for most of these deaths, followed by stroke and heart failure.
referenceMichels da Silva D, Langer H, and Graf T (2019) discuss inflammatory and molecular pathways in heart failure, specifically regarding ischemia, heart failure with preserved ejection fraction (HFpEF), and transthyretin cardiac amyloidosis.
Western Diet: How it affects health, risks, and complications medicalnewstoday.com Oct 27, 2023 1 fact
measurementA 2021 analysis found that high levels of fried food consumption in the Western diet, compared to the lowest levels of consumption, were associated with a 28% higher risk of major cardiovascular events (such as heart attack or stroke), a 22% increased risk of heart disease, and a 37% heightened risk of heart failure.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 1 fact
referenceQuashie et al. (2017) evaluated the effectiveness of the drug digoxin in the treatment of heart failure.
Male menopause: Myth or reality? - Mayo Clinic mayoclinic.org Mar 26, 2025 1 fact
claimHealthcare professionals may recommend against testosterone therapy for men with a history of breast or prostate cancer, untreated severe obstructive sleep apnea, uncontrolled heart failure, a history of blood clots in the legs or lungs, or a recent heart attack or stroke.
Overview of Anxiety Disorders - Psychiatry - MSD Manuals msdmanuals.com 1 fact
claimMedical disorders including asthma, cardiac arrhythmias, chronic obstructive pulmonary disease (COPD), heart failure, hyperthyroidism, Cushing syndrome, and pheochromocytoma can induce anxiety as a symptom.
EBM Tools for Practice: Best Biomarkers for Inflammation lipid.org 1 fact
claimIn the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial (STABILITY) and the Stabilization of Plaques using Darapladib — Thrombosis in Myocardial Infarction 52 (SOLID-TIMI 52) trial, interleukin-6 (IL-6) was significantly and independently associated with incident cardiovascular events, including cardiovascular death, myocardial infarction, and heart failure.
Bridging the Gap Between LLMs and Evolving Medical Knowledge arxiv.org Jun 29, 2025 1 fact
claimSpironolactone is useful in heart failure or reduced ejection fraction but is not indicated for acute coronary syndrome (ACS) management when the ejection fraction is normal.
How Testosterone Changes Affect Men's Health as You Age columbiadoctors.org Dec 16, 2025 1 fact
claimMen with prostate cancer, severe sleep apnea, uncontrolled heart failure, or elevated red blood cell counts typically should not receive testosterone replacement therapy.
Health and environmental impacts of diets worldwide globalnutritionreport.org 1 fact
referenceBechthold A, Boeing H, Schwedhelm C, et al. conducted a systematic review and dose-response meta-analysis of prospective studies on the relationship between food groups and the risk of coronary heart disease, stroke, and heart failure, published in Critical Reviews in Food Science and Nutrition in 2019.
The Effect of Insomnia on Brain Health - American Brain Foundation americanbrainfoundation.org Sep 17, 2025 1 fact
claimChronic insomnia and sleep deprivation increase the risk of hypertension, type 2 diabetes, obesity, heart failure, vascular disease, stroke, cognitive impairment, obstructive sleep apnea, Alzheimer’s disease, and mortality.
Stress, Lifestyle, and Health – Psychology 2e OpenStax pressbooks.cuny.edu 1 fact
claimHigh blood pressure resulting from significant job strain can damage the heart over time, potentially leading to heart attack or heart failure.