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randomized controlled trial
Also known as: RCT, randomized controlled trials, randomized control trial, RCTs, randomized clinical trial
Facts (36)
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A systematic review of cognitive behavioral therapy-based ... frontiersin.org 15 facts
claimThe evidence supporting the efficacy of Mindfulness-Based Interventions (MBI) for depression comes from a pilot Randomized Controlled Trial (RCT) with a small sample size (De Jong et al., 2016, 2018).
claimThe systematic review could not examine whether specific forms of cognitive behavioral therapy (CBT) are more effective than others due to the limited number of randomized controlled trials (RCTs).
measurementThe systematic review included twelve randomized controlled trials and one non-randomized controlled trial, involving a total of 1,661 participants.
referenceIn a 2016 randomized controlled trial conducted in Australia, Migliorini et al. studied patients with chronic spinal cord injury and depression or anxiety, comparing a treatment group receiving CBT (n=34) against a waitlist control group (n=25).
referenceIn a study by Torrijos-Zarcero et al. (2021) in Spain, patients with chronic pain, depression, and anxiety were treated in a randomized controlled trial comparing Mindfulness-Based Stress Reduction (MSC) (n=62) against Cognitive Behavioral Therapy (CBT) (n=61) using weekly face-to-face sessions.
measurementThe systematic review included 14 articles, consisting of 12 randomized controlled trials (RCTs) and 1 non-randomized controlled trial.
referenceTorrijos-Zarcero et al. (2021) conducted a randomized controlled trial to evaluate a mindful self-compassion program for patients with chronic pain.
claimThe systematic review included randomized controlled trials (RCTs) and non-RCTs, but excluded research with other study designs.
perspectiveMore randomized controlled trials (RCTs) based on Mindfulness-Based Interventions (MBI), Acceptance and Commitment Therapy (ACT), and Behavioral Activation Treatment for Depression (BATD) are needed to determine the overall efficacy of these interventions for patients with comorbid chronic pain and psychological distress.
claimThe systematic review included both Randomized Controlled Trials (RCTs) and non-RCTs of any follow-up length, provided the studies received ethical approval and were published in English or Spanish.
referenceSanabria-Mazo et al. (2023) conducted a randomized controlled trial in Spain involving patients with chronic low back pain (CLBP) and depression, comparing Acceptance and Commitment Therapy plus Treatment as Usual (ACT+TAU), Behavioral Activation Therapy plus Treatment as Usual (BATD+TAU), and Treatment as Usual (TAU) alone.
measurementA systematic review of CBT-based interventions for patients with chronic pain and clinically relevant psychological distress analyzed twelve Randomized Controlled Trials (RCTs) and one non-RCT published between 2011 and 2023, finding positive but modest results.
claimEvidence is emerging regarding the effects of third-wave CBT therapies compared with treatment as usual (TAU), but further research is required to determine which therapy is most effective for specific circumstances and populations, as supported by studies from De Jong et al. (2016, 2018), Gardiner et al. (2019), Bell et al. (2020), Torrijos-Zarcero et al. (2021), and Sanabria-Mazo et al. (2023).
claimBell et al. (2020) are conducting an upcoming Randomized Controlled Trial (RCT) to evaluate the efficacy of internet-delivered Acceptance and Commitment Therapy (ACT) and internet-delivered Cognitive Behavioral Therapy (CBT) compared to attention control in patients with chronic non-cancer pain and major depression.
referenceIn a 2015 randomized controlled trial conducted in Sweden, Buhrman et al. studied patients with chronic pain (CP) and depression, comparing a treatment group receiving CBT plus treatment as usual (TAU) (n=28) against a control group receiving only TAU (n=24).
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 3 facts
claimA randomized controlled trial (RCT) investigating music with ketamine found that both music and non-music interventions were effective and tolerable in a patient population characterized by high rates of comorbidity, suicidality, and chronicity.
measurementA randomized controlled trial (RCT) involving 32 patients compared the effects of music versus matched non-music support (such as relaxation or mindfulness exercises) during ketamine treatments.
accountThe Montreal model of psychedelic therapy was evaluated in a randomized controlled trial (RCT) examining the effects of music on ketamine infusions in patients with treatment-resistant depression (TRD).
Track: Poster Session 3 - aistats 2026 virtual.aistats.org 2 facts
claimRemi Khellaf, Aurélien Bellet, and Julie Josse derived the asymptotic variance of ATE estimators for linear models in the context of Randomized Controlled Trials (RCTs).
claimAnup Rao and Peng Zhang investigate experimental design for randomized controlled trials (RCTs) involving both equal and unequal treatment-control assignment probabilities.
Evidence-Based Treatments for Anxiety, Depression, and Behavior ... advancedtherapeuticsolutions.org 2 facts
quoteThe APA Dictionary of Psychology defines a randomized-clinical trial as "an experimental design in which patients are randomly assigned to a group that will receive an experimental treatment, such as a new drug, or to one that will receive a comparison treatment, a standard-of-care treatment, or a placebo. The random assignment occurs after recruitment and assessment of eligibility but before the intervention. There may be multiple experimental and comparison groups, but each patient is assigned to one group only. Also called randomized controlled trial."
procedureA randomized-clinical trial follows this procedure: (1) recruitment and assessment of patient eligibility, (2) random assignment of patients to either an experimental treatment group, a comparison treatment group, a standard-of-care treatment group, or a placebo group, and (3) administration of the intervention.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
claimThe clinical efficacy of vitamin D supplementation in the prevention and treatment of autoimmune diseases remains uncertain due to a lack of randomized controlled trials.
claimA 2013 review of six trials regarding vitamin C supplementation for pneumonia prevention or treatment found only two double-blind, placebo-controlled, randomized controlled trials, leading to the conclusion that prophylactic use of vitamin C supplements for pneumonia cannot be advocated for the general population due to methodological shortcomings and variable study populations.
Knowledge graphs - Amazon Science amazon.science 1 fact
procedureThe Measurement & Experimentation role at Amazon involves owning measurement end-to-end for lifecycle marketing campaigns by designing experiments such as randomized controlled trials (RCTs), geo-tests, and audience holdouts; building measurement frameworks and experimental best practices; and establishing experimental standards and tooling for lifecycle marketing.
Measurement of diets that are healthy, environmentally sustainable ... frontiersin.org 1 fact
claimEligible study designs for the review included cross-sectional studies, case-control studies, experimental studies (including uncontrolled, non-randomized controlled, and randomized controlled trials), cohort studies (retrospective and prospective), and optimization modeling studies.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 1 fact
referenceThe systematic review 'Control Conditions in Randomized Trials of Psychedelics: An ACTTION Systematic Review' by Nayak et al. was published in the Journal Clinical Psychiatry in 2023.
Long-Term Effects of Chronic Sleep Deprivation empowersleep.com Mar 15, 2023 1 fact
referenceBlack et al. (2015) conducted a randomized clinical trial published in JAMA Internal Medicine, which found that mindfulness meditation improved sleep quality and reduced daytime impairment among older adults with sleep disturbances.
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 1 fact
measurementIn a randomized clinical trial, caffeine and modafinil demonstrated similar benefits for performance and alertness.
U shaped association between sleep duration and long ... nature.com by F Feng · 2025 1 fact
perspectiveFuture research should incorporate objective sleep measurements such as polysomnography and actigraphy, and conduct randomized controlled trials to determine if sleep duration interventions targeting the optimal range of 7.23 hours can reduce dementia risk.
Introduction to children's attachment - NCBI - NIH ncbi.nlm.nih.gov 1 fact
claimThe Washington State research group developed the Circle Of Security intervention, which has not yet been subjected to a randomized controlled trial (RCT).
Diet Quality Indices: Measures for Bridging Nutrition and Public Health link.springer.com 2 days ago 1 fact
referenceLiu X, Morris MC, Dhana K et al. (2021) described the rationale, design, and baseline characteristics of a randomized control trial of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on cognitive decline, published in Contemp Clin Trials 102:106270.
Work environment risk factors causing day-to-day stress in ... link.springer.com Feb 5, 2022 1 fact
claimModifying work schedules is a potential intervention to reduce job strain, but the authors of the systematic review note that only a randomized clinical trial can definitively assess its effectiveness.
Efficacy of Cognitive Behavioral Therapy for Anxiety-Related Disorders link.springer.com Dec 19, 2022 1 fact
claimTreatment as Usual (TAU) is considered a suboptimal control condition in Randomized Controlled Trials (RCTs) because it is associated with type 1 errors that result in an overestimation of treatment effect size.
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 1 fact
claimClinical and mechanistic research into psychedelics was effectively halted for nearly 50 years due to legal restrictions and a shift in medical research standards toward randomized controlled trials.
EdinburghNLP/awesome-hallucination-detection - GitHub github.com 1 fact
referenceEvaluation metrics for the FactCC, Polytope, SummEval, Legal Contracts, and RCT datasets include EM (Exact Match) and Memorisation ratio.