Knowledge Tree
insulin resistance
Also known as: insulin resistance syndrome
Facts (30)
Sources
Origins and evolution of the Western diet: health implications for the ... academia.edu 7 facts
referenceZammit VA, Waterman IJ, Topping D, and McKay G examined the role of insulin stimulation of hepatic triacylglycerol secretion in the etiology of insulin resistance in a 2001 article in the Journal of Nutrition.
referenceThomson MJ, Williams MG, and Frost SC investigated the development of insulin resistance in 3T3-L1 adipocytes in a 1997 study published in the Journal of Biological Chemistry.
referenceGerald M. Reaven published a review on the pathophysiology of insulin resistance in human disease in Physiological Reviews in 1995.
referenceElliott SS, Keim NL, Stern JS, Teff K, and Havel PJ published a review in 2002 linking fructose consumption to weight gain and the insulin resistance syndrome.
measurementRefined sugars and grains comprise 39% of the typical United States diet's energy intake, which promotes insulin resistance.
referenceC. Taghibiglou, A. Carpentier, S.C. Van Iderstine, et al. published research on the mechanism of hepatic very low density lipoprotein overproduction in insulin resistance in the Journal of Biological Chemistry in 2000.
referenceBoden G and Shulman GI defined the role of free fatty acids in obesity and type 2 diabetes, specifically regarding their role in the development of insulin resistance and beta-cell dysfunction, in a 2002 article in the European Journal of Clinical Investigation.
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 3 facts
referenceCircadian misalignment increases markers of insulin resistance and inflammation independently of sleep loss, according to a 2014 study by Leproult, Holmbäck, and Van Cauter published in Diabetes.
referenceSleep influences obesity, insulin resistance, and the risk of type 2 diabetes, according to a 2018 article by S. Reutrakul and E. Van Cauter in Metabolism: Clinical and Experimental.
referenceTumour necrosis factor antagonists affect insulin sensitivity and resistance in patients with rheumatoid arthritis.
Western diet – Knowledge and References - Taylor & Francis taylorandfrancis.com 3 facts
claimInsulin resistance causes lipid accumulation and lipid peroxidation in the liver of rats.
measurementA high-fat and high-carbohydrate diet consisting of 46.1% fat, 35.8% carbohydrate, and 18.1% protein by weight causes insulin resistance in rats, characterized by increased Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and fasting blood glucose (FBG) levels.
claimLong-term consumption of high-fat and high-carbohydrate foods, characteristic of the Western diet, is associated with obesity, insulin resistance, hypertriglyceridemia, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH), as well as inflammatory and oxidative stress conditions.
A Consensus Proposal for Nutritional Indicators to Assess ... - Frontiers frontiersin.org 2 facts
procedureThe 'Diet-Related Morbidity/Mortality Statistics' indicator uses two primary parameters: (1) the prevalence of individuals with physician-diagnosed obesity, cardiovascular diseases (CHD, stroke, hypertension), type II diabetes, osteoporosis, neurodegenerative diseases, and obesity-related cancers; and (2) disability-adjusted life years (DALYs) as a measure of disease burden associated with nutrition-related factors like high blood pressure, high cholesterol (total and LDL), and high blood sugar (insulin resistance/diabetes).
claimIncreased waist circumference can serve as a marker for increased health risk, including insulin resistance, even in individuals who are of normal weight.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 2 facts
referenceNair et al. (2024) discuss the importance and scope of traditional medicinal plants in the holistic management of occupational lifestyle disorders, with a specific focus on clinical syndromes associated with insulin resistance.
claimBioactive compounds derived from garlic, onion, and Andrographis paniculata mitigate insulin resistance in patients with type 2 diabetes by decreasing cellular inflammation and augmenting insulin signaling pathways.
Male Hormone Changes by Age & Solutions - Infusion Health infusionhealth.org Jul 21, 2025 2 facts
Implications of the Western Diet for Agricultural Production, Health ... frontiersin.org 2 facts
claimIn the USA, rising temperatures resulting from global climate change may deactivate metabolic processes in brown adipose tissue, potentially leading to insulin resistance and an increased prevalence of diabetes, according to Blauw et al. (2017).
referenceMaccdonald (2016) reviewed recent evidence regarding the relationship between sugars, insulin resistance, and diabetes.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
claimObesity is characterized by chronic, low-grade inflammation, which is considered an important contributor to the pathogenesis of insulin resistance.
referenceOlefsky JM and Glass CK published a review titled 'Macrophages, inflammation, and insulin resistance' in the Annual Review of Physiology, volume 72, pages 219-246.
The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu Feb 10, 2015 2 facts
Origins and evolution of the Western diet: health implications for the ... sciencedirect.com 1 fact
claimDiseases of insulin resistance are rare or absent in hunter-gatherer and other less westernized societies that maintain traditional diets and lifestyles, according to research cited in the article 'Origins and evolution of the Western diet: health implications for the ...'.
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Jul 1, 2024 1 fact
claimA healthy living index can be used to explore the link between lifestyle, inflammation, and insulin resistance, as proposed by Bruckner et al. in 2024.
Understanding the Difference Between Men & Women Hormones prestonspharmacy.com Jan 13, 2026 1 fact
claimMetformin is often prescribed for both men and women to treat insulin resistance, particularly in cases of polycystic ovary syndrome (PCOS).
Understanding chronic inflammation: Causes, symptoms and ... uhc.com 1 fact
quoteSonya Angelone states: "High-sugar foods can increase uric acid levels, which drive inflammation and can lead to insulin resistance."
Physiology, Male Reproductive System - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimComorbidities associated with low testosterone include metabolic syndrome, insulin resistance, and atherosclerosis.