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ascorbic acid
Also known as: AA
Facts (34)
Sources
Comparison of Traditional Indigenous Diet and Modern Industrial ... isom.ca Feb 26, 2024 17 facts
claimDehydroascorbate (DHA) is taken up by glucose transporters GLUT1, GLUT3, and GLUT4, but only the GLUT1 transporter is utilized for ascorbic acid (AA) recycling in humans, as noted by Hornung and Biesalski (2019).
claimIn the human body, vitamin C exists in two main forms: ascorbic acid (AA) and dehydroascorbate (DHA), as stated by Packer (1997).
accountWillis and Fishman (1955) observed an acute deficiency of ascorbic acid (AA) in arterial ground substance in the presence of atherosclerotic plaques.
claimThe Inuit traditionally select animal parts with high Ascorbic Acid (AA) concentrations for consumption.
claimAscorbic Acid (AA) acts as an enzyme co-factor for Dopamine-b-hydroxylase in the synthesis of catecholamines and for prolyl-4-hydroxylase in collagen hydroxylation.
claimAscorbic Acid (AA) is required for insulin secretion from pancreatic islets in scorbutic guinea pigs.
claimPlaque buildup associated with ascorbic acid (AA) deficiency is reversible with intravenous AA therapy, with resolution timelines dependent on the severity of the plaques, according to Lamas et al. (2013) and Willis (1957).
claimMammals that synthesize their own Ascorbic Acid (AA) have the highest concentrations in the adrenals, pituitary, brain, liver, lung, and thyroid, while humans have the highest concentrations in lymphocytes, monocytes, pituitary, adrenals, eye lens, and brain.
claimIndividual requirements for Ascorbic Acid (AA) vary based on dietary glycemic load because AA and glucose compete due to their molecular similarity.
claimAscorbic acid (AA) is transported into cells via sodium-dependent vitamin C transporters SVCT1 and SVCT2, as reported by Rivas et al. (2008).
claimDiets with elevated carbohydrate levels and blood glucose may lead to reduced insulin secretion if Ascorbic Acid (AA) levels decline, potentially contributing to metabolic syndrome and diabetes.
claimThe evolutionary loss of the L-gulono-lactone-oxidase (GLO) enzyme, which is responsible for producing ascorbic acid (AA), is associated with frugality and the seasonal scarcity of AA, according to Hornung and Biesalski (2019).
claimThe Trial to Assess Chelation Therapy (TACT-1) compared data from type 2 diabetic populations to non-diabetics treated with intravenous Ascorbic Acid (AA) to determine ascorbate needs.
procedureRed blood cells (RBC) in humans express only GLUT1 transporters and not the SVCT family of transporters; they recycle ascorbic acid (AA) by taking up dehydroascorbate (DHA) from circulation and immediately reducing it to AA inside the cell via glutaredoxin and reduced glutathione, as described by Padayatty and Levine (2016).
claimThe lack of ascorbic acid (AA) causes a depolymerisation of the arterial ground substance and subsequent plaque buildup in chronic diseases such as cancer and diabetes, which further compromises microvascular blood flow, as noted by Willis (1957).
measurementThe average lifespan of red blood cells (120 days) corresponds to the onset of scurvy as the rate of ascorbic acid (AA) recycling in RBCs declines until the plasma level reaches below 10 mmol L-1, as noted by Carr and Cook (2018) and Léger (2008).
referenceClow, Laberge, and Scriver (1975) documented neonatal hypertyrosinemia and evidence for a deficiency of ascorbic acid in Arctic and subarctic peoples.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 9 facts
referenceA 1986 study by Vogel RI et al. published in the Journal of Periodontology examined the effects of megadoses of ascorbic acid on polymorphonuclear leukocyte (PMN) chemotaxis and experimental gingivitis.
referenceS. Vallance published a study in the British Medical Journal in 1977 regarding the relationships between ascorbic acid and serum proteins of the immune system.
referenceSchwager J, Bompard A, Weber P, and Raederstorff D published a study in Molecular Nutrition & Food Research in 2015 regarding how ascorbic acid modulates cell migration in differentiated HL-60 cells and peripheral blood leukocytes.
referenceA 1982 study by Evans RM, Currie L, and Campbell A published in the British Journal of Nutrition analyzed the distribution of ascorbic acid between various cellular components of blood in normal individuals and its relation to plasma concentration.
referenceHuijskens MJ, Walczak M, Koller N, et al. published a study in the Journal of Leukocyte Biology in 2014 reporting that ascorbic acid induces the development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells.
referenceJariwalla RJ and Harakeh S published a chapter in the 1996 book 'Ascorbic Acid: Biochemistry and Biomedical Cell Biology' regarding the antiviral and immunomodulatory activities of ascorbic acid.
referenceA 1976 study by Dahl H and Degré M published in Acta Pathologica et Microbiologica Scandinavica Section B examined the effect of ascorbic acid on the production of human interferon and its antiviral activity in vitro.
referenceA 1990 study by Bergsten P et al. published in the Journal of Biological Chemistry reported that purified human mononuclear leukocytes contain millimolar concentrations of ascorbic acid, which can be depleted and reaccumulated.
referencePrinz W, Bortz R, Bregin B, and Hersch M published a study in the International Journal for Vitamin and Nutrition Research in 1977 examining the effect of ascorbic acid (vitamin C) supplementation on parameters of the human immunological defense system.
Nutritional potential of underutilized edible plant species in coffee ... link.springer.com Apr 23, 2021 3 facts
referenceUddin et al. (2012) reported that mature leaves of Portulaca oleracea contain high amounts of calcium, iron, and zinc. Wenzel et al. (1990) further identified that Portulaca oleracea shoots are abundant in omega-3 fatty acid, α-tocopherol, ascorbic acid, β-carotene, and glutathione, making the plant a source of minerals, vitamins, and antioxidants for functional foods and nutraceutical applications.
claimAscorbic acid contributes to the absorption of iron, which is relevant for the benefits of iron-rich green vegetables and fruits in preventing anaemia.
referenceYadav and Sehgal (1995) investigated the effect of home processing on the ascorbic acid and beta-carotene content of spinach (Spinacia oleracea) and amaranth (Amaranthus tricolor) leaves.
Ethnobotanical and Food Composition Monographs of Selected ... ouci.dntb.gov.ua 3 facts
referenceAndarwulan et al. (2012) analyzed the content of polyphenols, carotenoids, and ascorbic acid in underutilized medicinal vegetables, published in the Journal of Functional Foods.
referenceKiliç and Coşkun (2007) conducted a comparative study on the ascorbic acid content of Capsella bursa-pastoris (L.) Medik.
referenceJabłońska-Ryś et al. (2009) analyzed the antioxidant capacity, ascorbic acid, and phenolics content in wild edible fruits.
Vernonia amygdalina: a comprehensive review of the ... frontiersin.org 1 fact
measurementA compound from Vernonia amygdalina inhibits HT-29 cell viability with an IC50 of 5.7 µM and exhibits antioxidant activity with a scavenger effect comparable to ascorbic acid.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimVitexdoin F exhibits stronger antioxidant activity than ascorbic acid in DPPH radical-scavenging assays.