Hypertrophied adipose tissue contributes to an inflammatory state through four mechanisms: (1) altered adipokine secretion, specifically increased pro-inflammatory leptin and reduced anti-inflammatory adiponectin; (2) release of free fatty acids that induce systemic inflammation; (3) increased endoplasmic reticulum stress triggered by adipocyte expansion, leading to oxidative stress and inflammation; and (4) increased inflammatory gene expression and immune cell activation in hypoxic regions.

Authors

• Person: Not available Organization: Linus Pauling Institute
  Immunity In Depth | Linus Pauling Institute

Sources

• Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu Linus Pauling Institute via serper

Referenced by nodes (5)

• oxidative stress concept
• inflammation concept
• systemic inflammation concept
• leptin concept
• pro-inflammatory cytokine genes concept