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pro-inflammatory cytokine genes
Also known as: inflammatory gene expression, pro-inflammatory cytokine genes, inflammatory genes
Facts (11)
Sources
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 3 facts
claimWhen a bacterium binds to surface receptors on a macrophage, it simultaneously triggers intracellular signaling that activates the transcription of pro-inflammatory cytokine genes in the nucleus, leading to the production and secretion of cytokines that act on nearby cells.
claimHypertrophied adipose tissue contributes to an inflammatory state through four mechanisms: (1) altered adipokine secretion, specifically increased pro-inflammatory leptin and reduced anti-inflammatory adiponectin; (2) release of free fatty acids that induce systemic inflammation; (3) increased endoplasmic reticulum stress triggered by adipocyte expansion, leading to oxidative stress and inflammation; and (4) increased inflammatory gene expression and immune cell activation in hypoxic regions.
claimVisceral fat accumulation (central adiposity) is more strongly associated with inflammation and adverse metabolic risk factors than subcutaneous fat, as it displays increased macrophage infiltration, lower adiponectin gene expression, and increased inflammatory gene expression.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 2 facts
claimCurcumin inhibits the DNA binding activity of the p65 subunit, which obstructs the transcription of inflammatory genes including IL-1β, IL-6, and COX-2.
claimCurcumin and gingerols modulate inflammatory gene expression at the post-transcriptional level by affecting the expression of microRNAs miR-146a and miR-155.
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Jul 1, 2024 2 facts
claimSocial and physical environments during early development are predictive of DNA methylation of inflammatory genes in young adulthood, according to a 2017 study by McDade et al.
claimMutations in age-related, clonal hematopoiesis of indeterminate potential (CHIP) increase the expression of inflammatory genes, which is associated with nearly double the risk of coronary artery disease.
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au Jan 2, 2026 2 facts
claimWell-being therapy, developed by Fava, focuses on building optimal wellbeing (euthymia) rather than merely reducing symptoms, an approach that shows reduced inflammatory gene expression.
claimWell-being therapy, developed by Fava, focuses on building optimal wellbeing (euthymia) rather than merely reducing symptoms, an approach showing reduced inflammatory gene expression.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 1 fact
referencePericentromeric noncoding RNA alters the DNA binding of CTCF and influences inflammatory gene expression in senescence and cancer, as reported in the 2021 paper 'Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer' published in the Proceedings of the National Academy of Sciences.
The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu Feb 10, 2015 1 fact
claimNuclear transport modifiers increased survival in mice exposed to high doses of a bacterial endotoxin by preventing the expression of inflammatory genes.