Knowledge Tree
systemic inflammation
Also known as: systemic inflammatory response, systemic immune inflammation
Facts (23)
Sources
Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Jul 1, 2024 5 facts
perspectiveSystemic inflammation and poverty should be a focus of primary care for preventing disease and monitoring its progression.
claimAn index based on daily step count and systemic inflammation levels predicts clinical outcomes in patients with chronic obstructive pulmonary disease.
claimHealthy lifestyles are associated with systemic inflammation and breast cancer risk, with systemic inflammation acting as a mediator, according to a 2024 analysis by Zhang et al.
referenceElevated systemic immune inflammation levels increase the risk of total and cause-specific mortality among patients with chronic kidney disease, according to a 2023 multi-center longitudinal study published in Inflammation Research.
claimSystemic inflammation is associated with cancer-related mortality, cardiovascular mortality, and all-cause mortality according to a 2017 study by Singh-Manoux et al.
A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org Feb 12, 2021 4 facts
claimReducing systemic inflammation may decrease the incidence of diseases affecting the heart, lungs, joints, and brain.
claimSystemic inflammation can potentially be delayed or prevented by eating a diversity of whole foods, particularly fiber-rich fruits and vegetables, and avoiding unnecessary antibiotics.
perspectiveSuzanne Devkota hypothesizes that systemic inflammation likely originates in the gut because the gastrointestinal tract is a hollow tube that encounters foreign substances before the rest of the body.
quote"It's highly likely that living a lifestyle that limits systemic inflammation and infection is going to diminish the negative effects of aging."
Tracking Inflammation Through Biomarkers rupahealth.com Jul 24, 2024 3 facts
claimElevated levels of IL-6 and TNF-alpha are associated with systemic inflammation, such as that seen in sepsis.
claimBiomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) help differentiate whether systemic inflammation is caused by infectious sources.
claimSystemic inflammation can be caused by infectious sources or noninfectious causes, including pancreatitis, cardiac ischemia, bowel perforation, vasculitis, and pulmonary embolism.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 2 facts
Male Hormone Changes by Age & Solutions - Infusion Health infusionhealth.org Jul 21, 2025 1 fact
claimChronically elevated cortisol levels in men contribute to muscle breakdown, visceral abdominal fat storage, cognitive fog, and systemic inflammation.
Healthy vs. Infected Wounds: A Clinician's Guide - Net Health nethealth.com Jun 24, 2025 1 fact
claimInfected wounds are characterized by delayed healing, purulent drainage, and a systemic inflammatory response.
The Center for Inflammation Science and Systems Medicine wertheim.scripps.ufl.edu 1 fact
claimThe regulation of inflammatory processes can be corrupted by factors such as genetics, leading to excessive and sustained systemic inflammation that causes harm to patients.
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 1 fact
referenceSystemic inflammation is a predictor of all-cause mortality.
Inflammation: Definition, Diseases, Types, and Treatment - WebMD webmd.com Jul 14, 2024 1 fact
claimSystemic inflammation can cause flu-like symptoms, including headache, fatigue, fever, chills, or achy muscles.
Inflammatory Markers | Choose the Right Test arupconsult.com Jun 16, 2025 1 fact
claimC-Reactive Protein (CRP) concentrations are a reliable early indicator of active systemic inflammation and reflect the severity of the inflammatory insult.
Wound Inflammation lakecountyin.gov 1 fact
claimDiagnostic testing for wound inflammation includes wound cultures to identify causative pathogens if infection is suspected, and blood tests to assess for systemic inflammation, infection, or underlying conditions affecting healing.
How the Modern Western Diet is Destroying Us cornellhealthcarereview.org Dec 18, 2025 1 fact
claimThe gut-brain axis is a bi-directional communication network that, in tandem with the gut lining, protects the human body from systemic inflammation by serving as a barrier that limits toxins.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
claimHypertrophied adipose tissue contributes to an inflammatory state through four mechanisms: (1) altered adipokine secretion, specifically increased pro-inflammatory leptin and reduced anti-inflammatory adiponectin; (2) release of free fatty acids that induce systemic inflammation; (3) increased endoplasmic reticulum stress triggered by adipocyte expansion, leading to oxidative stress and inflammation; and (4) increased inflammatory gene expression and immune cell activation in hypoxic regions.