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The ventral anterior cingulate cortex (ACC) has strong connections to limbic structures (amygdala, hippocampus), cortical areas mediating limbic structures (orbitofrontal cortex and anterior insula), the periaqueductal gray, the nucleus accumbens, and the hypothalamus, giving it a central role in assessing and mediating emotionally salient stimuli, as stated by Washington and VanMeter (2015).

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