Knowledge Tree
nucleus accumbens
Also known as: nucleus accumbens (NAcc)
Facts (11)
Sources
Self-awareness, self-regulation, and self-transcendence (S-ART) frontiersin.org 4 facts
referenceDavidson and Irwin (1999) delineated functional differences between the ventromedial and dorsolateral sectors of the prefrontal cortex (PFC), suggesting that activation of the ventromedial PFC represents immediate valenced goal states along with activation of the ventral striatopallidum (including the nucleus accumbens), while the dorsolateral PFC represents valenced goal states in the absence of immediately present incentives.
referenceBrain areas critical for their interactions with the prefrontal cortex (PFC) in emotion regulation include the amygdala, hippocampus, striatum (including the nucleus accumbens), thalamus, and insula.
claimThe ventromedial prefrontal cortex (VMPFC) supports the representation of affective and motivational states through a gradient of non-conscious and conscious affective appraisal by maintaining heavy interconnections with the amygdala and the ventral striatal pallidal complex, including the nucleus accumbens.
claimActivity in the prefrontal cortex (PFC) can modulate ventral striatopallidum and nucleus accumbens activity in a top-down manner, providing a mechanism for tracking internally driven approach motivation (Heller et al., 2009) and regulating craving associated with phasic nucleus accumbens activity (Robbins and Everitt, 1996).
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Dec 19, 2024 3 facts
claimChronic THC exposure during adolescence reduces BDNF levels via the CREB pathway in the hippocampus and prefrontal cortex of male rats, while paradoxically increasing BDNF in the nucleus accumbens of female rats.
measurementIbogaine treatment (at both 20 mg/kg and 40 mg/kg) resulted in the upregulation of proBDNF protein in the nucleus accumbens (NAcc) and GDNF protein in the ventral tegmental area (VTA) exclusively for the 40 mg/kg dose, as observed by Marton et al. (2019).
measurementIbogaine administration at doses of 20 mg/kg and 40 mg/kg dose-dependently upregulated BDNF and NGF mRNA in the prefrontal cortex (PFC), ventral tegmental area (VTA), substantia nigra (SN), and nucleus accumbens (NAcc) of rat brains 24 hours post-injection, according to Marton et al. (2019).
Is There a Male Brain and a Female Brain? | Child & Family Blog childandfamilyblog.com 1 fact
claimStudies of the pallidum, thalamus, cerebellum, and nucleus accumbens have found no significant sex/gender differences in average size.
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Sep 27, 2017 1 fact
referenceThe ventral anterior cingulate cortex (ACC) has strong connections to limbic structures (amygdala, hippocampus), cortical areas mediating limbic structures (orbitofrontal cortex and anterior insula), the periaqueductal gray, the nucleus accumbens, and the hypothalamus, giving it a central role in assessing and mediating emotionally salient stimuli, as stated by Washington and VanMeter (2015).
Western diet – Knowledge and References - Taylor & Francis taylorandfrancis.com 1 fact
claimSucrose consumption mimics the effects of nucleus accumbens µ-opioid receptor stimulation on fat intake and brain c-Fos-expression.
GWT: A Leading Consciousness Theory Depends on Information ... mindmatters.ai Oct 15, 2021 1 fact
referenceMorten L. Kringelbach and Gustavo Deco identify the global workspace as a core subset of brain regions including the precuneus, the posterior and isthmus cingulate, nucleus accumbens, putamen, hippocampus, and amygdala.