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Silibinin
Also known as: Silibinin, Silybin
Facts (24)
Sources
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 24 facts
claimSilybin derived from Silybum marianum possesses properties specific to Gram-positive bacteria, as reported by Lee DG et al. in 2003.
claimSilybin, an active constituent found in Silybum marianum, exhibited higher binding affinity with targets in SARS-CoV-2 compared to existing drugs against SARS-CoV-2.
claimSilybin downregulates the Slit-2/Robo-1 pathway and mir-92-3p, while upregulating mir223-3p and mir16-5p in hepatocarcinoma, according to Zappavigna et al. [99].
claimSilybin and related flavonolignans demonstrate in-vitro activity against Leishmania infantum and Leishmania donovani, according to a 2018 study by Olias-Molero AI et al.
measurementThe Chinese Pharmacopeia specifies that silybin should constitute 0.6% of standardized Silybum marianum herbs.
measurementSilymarin, a standardized extract from Silybum marianum seeds, is composed of 40-65% silybin, 20-45% silychristin, and 10-20% isosilybin, and constitutes 70-80% of the plant's hydro-alcoholic extract.
claimSilybin reduces the migratory and adhesive capacities of MDA-MB-231 breast cancer cells by affecting levels of b1-integrin and downstream molecules Cdc42, Raf-1, and D4GDI, and impairs mitochondrial dynamics and biogenesis, according to Sharifi et al. [102].
claimSilybin induces autophagy in breast cancer via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3; it also prevents TPA and PMA induced MMP-9 expression and VEGF secretion via inactivation of the Raf/MEK/ERK pathway and blockade of AP-1 activation via MAPK signaling pathways, according to Wang et al. [101].
claimSilybin-induced apoptosis in human hepatocarcinoma cells occurs in parallel with increased ceramide synthesis and miRNA secretion, as reported by Zappavigna S et al. in 2019.
claimSilymarin, silybin, and 2,3-dehydrosilybin reduce immunosuppression and oxidative stress in mouse skin, according to Katiyar et al. [107].
claimSilybin exhibits retinoic acid-like activity in keratinocytes, which is relevant to skin irritation.
claimSilibinin triggers yeast apoptosis in Candida albicans by causing a mitochondrial calcium influx, according to a 2016 study by Yun DG and Lee DG.
claimSilibinin inhibits HIV-1 infection by reducing cellular activation and proliferation, as reported by McClure J et al. in 2012.
claimSilybin increases hair-inductive properties via Akt and Wnt/-catenin signaling activation in human dermal papilla cells, according to Karbasforooshan et al.
claimSilybin attenuates cellular functions involved in T-cell activation, proliferation, and HIV-I infection, according to McClure et al. [95].
referenceSilibinin, a compound from Silybum marianum seeds, inhibits confluent-induced keratinocyte differentiation as effectively as retinoic acid without inducing inflammatory cytokines, according to a 2009 study by Kitajima and Yamaguchi.
claimSilybin inhibits RNA and protein synthesis in gram-positive bacteria.
measurementWounds treated with 0.2% silybin gel showed more collagen fibers, fibroblasts, and proliferating blood capillaries, according to Hu et al. [104].
claimSilibinin induces protective superoxide generation in human breast cancer MCF-7 cells, as reported by Wang HJ et al. in 2010.
referenceThe flavonoid Silibinin increases hair-inductive properties in 3-dimensional-spheroid cultured human dermal papilla cells via Akt and Wnt/beta-Catenin signaling activation, as reported by Cheon, Bae, and Ahn in 2019.
claimSilybin, isosilybin, and silychristin are the main active flavonolignan ingredients of Silybum marianum.
claimSilybin prevents or manages advanced glycation end product (AGE)-mediated pathologies related to skin aging.
claimSilybin inhibits RNA and protein synthesis in the gram-positive bacterium Staphylococcus epidermidis, according to Lee et al. [93].
measurementSilybin is a chemical compound found in Silybum marianum with the molecular formula C25H22O10.