concept

ghrelin

Facts (16)

Sources

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 4 facts

measurementA small randomized, cross-over clinical trial found that sleep restriction was associated with lower leptin levels and higher ghrelin levels (Spiegel et al., 2004).

referenceSpiegel, Tasali, Penev, and Van Cauter found that sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite, as published in the Annals of Internal Medicine in 2004.

claimSleep insufficiency increases appetite by lowering levels of leptin (an appetite-suppressing hormone produced by adipose tissue) and raising levels of ghrelin (an appetite-stimulating peptide), according to a study by Taheri et al. (2004).

claimSleep insufficiency is associated with lower levels of leptin (an appetite-suppressing hormone produced by adipose tissue) and higher levels of ghrelin (a peptide that stimulates appetite), which suggests a hormonally mediated increase in appetite explains the link between short sleep and obesity (Taheri et al., 2004).

Why Is Sleep Important for Our Mental and Physical Health? insightspsychology.org Insights Psychology Oct 29, 2024 2 facts

claimLack of sleep disrupts the balance of the hormones ghrelin, which stimulates hunger, and leptin, which signals fullness.

claimInsufficient sleep increases ghrelin levels and decreases leptin levels, causing individuals to feel hungrier and less satisfied after meals.

Long-Term Effects of Chronic Sleep Deprivation empowersleep.com Empower Sleep Mar 15, 2023 1 fact

claimChronic sleep deprivation increases the risk of obesity and weight gain by disrupting the balance of appetite-regulating hormones leptin and ghrelin, which leads to increased hunger and food consumption.

Short- and long-term health consequences of sleep disruption dovepress.com Goran Medic, Micheline Wille, Michiel EH Hemels · Dove Press May 19, 2017 1 fact

claimSleep abnormalities lead to metabolic changes including decreased leptin and increased ghrelin, which may contribute to increased appetite.

How Sleep Works: Understanding the Science of Sleep sleepfoundation.org Sleep Foundation Jul 8, 2025 1 fact

claimSleep affects the production of growth hormone, leptin, and ghrelin, which regulate appetite and may influence sleep-wake homeostasis and circadian rhythms.

Why Sleep Matters: Consequences of Sleep Deficiency sleep.hms.harvard.edu Harvard Medical School 1 fact

claimInsufficient sleep is associated with lower levels of leptin, a hormone that signals satiety to the brain, and higher levels of ghrelin, a biochemical that stimulates appetite.

10 Effects of Long-Term Sleep Deprivation sleephealthsolutionsohio.com Sleep Health Solutions Aug 20, 2025 1 fact

claimLong-term sleep deprivation is associated with an excess of ghrelin, a hormone produced in the stomach that increases feelings of hunger.

Altered State of Consciousness | Springer Nature Link link.springer.com Springer Sep 17, 2025 1 fact

referenceS. Taheri, L. Lin, D. Austin, T. Young, and E. Mignot published 'Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index' in PLoS Medicine in 2004.

The Effects of Sleep Deprivation on Your Body - Healthline healthline.com Healthline Aug 23, 2024 1 fact

claimSleep deprivation causes the brain to reduce levels of leptin and raise levels of ghrelin, which is an appetite stimulant.

Sleep Deprivation and Deficiency - How Sleep Affects Your Health nhlbi.nih.gov National Heart, Lung, and Blood Institute Jun 15, 2022 1 fact

claimSleep deficiency increases ghrelin levels and decreases leptin levels, which causes increased feelings of hunger.

7 Major Organ Systems: Functions and Connections instituteofhumananatomy.com Institute of Human Anatomy Nov 23, 2025 1 fact

claimThe endocrine system regulates digestion and metabolism through hormones such as gastrin, cholecystokinin (CCK), ghrelin, and leptin.

Physiology of Sleep - StatPearls - NCBI Bookshelf - NIH ncbi.nlm.nih.gov National Library of Medicine 1 fact

claimShort sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index, according to a 2004 study by Taheri et al. published in PLoS Medicine.