concept

cancer cells

Also known as: cancer cell, cancerous cells

Facts (21)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 6 facts

referenceLapasset et al. (2022) published 'Cancer cells as a new source of induced pluripotent stem cells' in Stem Cell Research & Therapy, exploring the potential of cancer cells for reprogramming.

claimCancer cells can establish a senescence response, which allows for the potential exploitation of senescence as a strategy to treat cancer.

claimSenescence-associated secretory phenotype (SASP) can contribute to angiogenesis, facilitate tumor development, induce epithelial-mesenchymal transition (EMT) in neighboring cancer cells, and induce extracellular matrix (ECM) degradation, which results in the migration and metastasis of cancer cells.

claimSomatic cell reprogramming suggests that cancer cells, which possess genetic and epigenetic plasticity, could theoretically be transformed back to benign cell functions.

referenceWnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells.

claimCancer-derived iPSCs can undergo multi-lineage differentiation into cell types including epithelial cells, mesenchymal cells, and neurons, and these differentiated cells are less aggressive and lack the tumor-forming ability of their parental cancer cells.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 5 facts

claimPyruvate dehydrogenase kinases (PDK) 1 and 3 are over-expressed in cancer cells and primed pluripotent stem cells (PSCs), where they inhibit the pyruvate dehydrogenase complex (PDC) and redirect pyruvate away from the mitochondria into lactate.

claimThe metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis during induced pluripotent stem cell (iPSC) generation is similar to the "Warburg effect" or "aerobic glycolysis" described by Otto Warburg in cancer cells, where cells maintain high glycolytic rates even in the presence of oxygen.

claimContrary to the initial postulate by Warburg that mitochondria in cancer cells are defective, current evidence indicates that mitochondria are essential for tumor growth and progression and may serve as a therapeutic target.

claimPluripotent stem cells (PSCs) and cancer cells may maintain low levels of mitochondrial DNA (mtDNA) replication by reducing the activity of the nuclear-encoded mitochondrial polymerase gamma A (POLGA) through hypermethylation at its exon 2.

claimCancer cells exhibit a radically different sensitivity to cell death compared to stem cells, as they are capable of surviving in the presence of high levels of reactive oxygen species (ROS) and DNA damage.

A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org Cedars-Sinai Feb 12, 2021 2 facts

quote"Low-level inflammation feeds cancer cells, encouraging them to grow, thrive and proliferate."

claimChronic inflammation may encourage the growth and survival of cancerous cells.

Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua Bhanumati Sarkar, Paramita Biswas, Suman Adhikari · International Academic Publishing House (IAPH) 2 facts

referenceThawabteh et al. (2019) reviewed the biological activity of natural alkaloids against herbivores, cancerous cells, and pathogens in the journal Toxins.

claimDing, H. & Fisher, D. E. (2002) identified new therapeutic opportunities for inducing apoptosis in cancer cells.

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 2 facts

claimAlkaloids, such as berberine and camptothecin, restore the function of the p53 tumor suppressor protein in mutant cancer cells.

claimPolyphenolic compounds, specifically resveratrol and EGCG, induce apoptosis in cancer cells by depolarizing the mitochondrial membrane and releasing cytochrome c.

Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 1 fact

claimEugenol, ursolic acid, linalool, and isoeugenol exhibit anti-neoplastic and anticancer properties by restricting cancer cell growth through apoptosis induction, cellular blockade, and inhibition of DNA synthesis, specifically demonstrating cytotoxic activity against Michigan Cancer Foundation-7 cells.

Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu International Academic Publishing House 1 fact

referenceDing and Fisher (2002) discussed the induction of apoptosis in cancer cells as a new therapeutic opportunity.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

claimA variant of the SLC1A5 gene functions as a mitochondrial glutamine transporter that facilitates metabolic reprogramming in cancer cells.

Vernonia amygdalina: a comprehensive review of the ... frontiersin.org Frontiers 1 fact

referenceNarayanan B. A., Geoffroy O., Willingham M. C., Re G. G., and Nixon D. W. (1999) investigated p53/p21 (WAF1/CIP1) expression and its role in G1 arrest and apoptosis in cancer cells treated with ellagic acid.