Cellular reprogramming for cardiac regenerative medicine treats cardiovascular disease (CVD) through three methods: (1) in vitro reprogramming of cells like fibroblasts into cardiomyocytes by initiating cardiac development programs to provide a cell source for regeneration; (2) in vivo cardiac reprogramming using lineage transcription factors or microRNA manipulation to convert resident cardiac fibroblasts into cardiomyocytes in situ; (3) partial reprogramming of mature cardiomyocytes into a fetal state to restore function in senescent cells by temporarily reactivating nascent developmental programs.

Authors

• Person: Not available Organization: Nature
  Cellular rejuvenation: molecular mechanisms and potential ... - Nature

Sources

• Cellular rejuvenation: molecular mechanisms and potential ... - Nature www.nature.com Nature via serper

Referenced by nodes (3)

• cardiomyocytes concept
• partial reprogramming concept
• cellular reprogramming concept