concept

cardiomyocytes

Also known as: functional cardiomyocytes

Facts (10)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 4 facts

claimCao, N. et al. demonstrated the conversion of human fibroblasts into functional cardiomyocytes using small molecules.

claimFibroblasts can be directly reprogrammed into cardiomyocytes, as reported by Chen et al. in Stem Cell Research & Therapy (2017).

procedureCellular reprogramming for cardiac regenerative medicine treats cardiovascular disease (CVD) through three methods: (1) in vitro reprogramming of cells like fibroblasts into cardiomyocytes by initiating cardiac development programs to provide a cell source for regeneration; (2) in vivo cardiac reprogramming using lineage transcription factors or microRNA manipulation to convert resident cardiac fibroblasts into cardiomyocytes in situ; (3) partial reprogramming of mature cardiomyocytes into a fetal state to restore function in senescent cells by temporarily reactivating nascent developmental programs.

claimHeart-specific in vivo reprogramming induces adult cardiomyocytes to a fetal state, conferring regenerative capacity and reducing myocardial infarction-induced damage.

A Hilbertian approach to biological problems | PLOS Complex ... journals.plos.org PLOS Nov 5, 2024 3 facts

claimThe phenomenon of altering electrophysiological properties in excitable membranes, such as those of neurons or cardiomyocytes, can be studied through mixed models combining recursion and dynamics.

claimRepetitive pacing transforms the electrophysiological attributes of cardiomyocytes to a new semi-stable state.

claimThe shift in the functional space of cardiomyocytes occurs through a reduction in the mRNA concentration of INa and ICa channels, which alters their expression.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 2 facts

claimThe proteins mitofusin 1 (MFN1), mitofusin 2 (MFN2), and optic atrophy 1 (OPA1) are required for the differentiation of stem cells into cells that depend on oxidative phosphorylation (OXPHOS) metabolism, such as cardiomyocytes and neurons.

claimNon-replicative cells, specifically neurons and cardiomyocytes, typically rely on oxidative phosphorylation (OXPHOS) for energy.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 1 fact

claimiPSC-based platforms have been utilized to investigate systemic stress responses to SARS-CoV-2 infection, revealing cytokine-driven feedback loops between infected tissues and circulating immune cells through the integration of transcriptomic data from cardiomyocytes and patient blood samples.