concept

cellular reprogramming

Also known as: stem cell reprogramming, nuclear reprogramming, cell reprogramming

Facts (15)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 11 facts

referenceA. Ocampo, P. Reddy, and J. C. I. Belmonte reviewed anti-aging strategies based on cellular reprogramming in Trends Mol. Med. (2016).

referenceGuan et al. (2011) published 'Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state' in Genes & Development, demonstrating that reprogramming can reverse aging markers in human cells.

claimCellular reprogramming contributes to cancer initiation, development, and recurrence.

procedureTechniques for cellular reprogramming that trigger the switch from malignancy to benignity include the use of transcription factors, chemical cocktails, microRNAs, and exosomes.

claimCellular reprogramming mediated by specific transcription factors or epigenetic gene mutations initiates cancer.

procedureCellular reprogramming for cardiac regenerative medicine treats cardiovascular disease (CVD) through three methods: (1) in vitro reprogramming of cells like fibroblasts into cardiomyocytes by initiating cardiac development programs to provide a cell source for regeneration; (2) in vivo cardiac reprogramming using lineage transcription factors or microRNA manipulation to convert resident cardiac fibroblasts into cardiomyocytes in situ; (3) partial reprogramming of mature cardiomyocytes into a fetal state to restore function in senescent cells by temporarily reactivating nascent developmental programs.

claimThe regulation of cellular reprogramming for malignancy conversion using microRNA or exosomes currently faces significant obstacles and lacks extensive research.

claimCellular reprogramming strategies can reverse age-related physiological changes and promote tissue regeneration by resetting the epigenetic clock and changing cell fate, but are limited by low reprogramming efficiency and safety concerns.

claimThe generation of cancer stem cells (CSCs) via cellular reprogramming contributes to therapy resistance and cancer recurrence, potentially serving as the biological basis for poor clinical outcomes.

claimCellular reprogramming mediates cancer development via cancer cell trans-differentiation or dedifferentiation.

claimIn vitro cellular reprogramming alleviates age-associated phenotypes and resets the age clock.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 4 facts

referencePrieto and Torres (2017) reviewed the role of mitochondrial dynamics in cell reprogramming and cancer.

referenceFolmes et al. (2011) reported that somatic oxidative bioenergetics transition into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

referencePrieto et al. (2016) found that early ERK1/2 activation promotes DRP1-dependent mitochondrial fission, which is necessary for cell reprogramming.

claimGlobal DNA hypomethylation is a feature of pluripotent stem cells (PSCs) required during cellular reprogramming to establish pluripotency.