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Obesity and insulin resistance are linked through shared metabolic pathways, where obesity-induced chronic inflammation contributes to the pathogenesis of insulin resistance [1]. Furthermore, both conditions are frequently co-occurring outcomes of Western diet consumption [2] and are identified as interconnected risk factors in clinical research regarding diabetes and cardiovascular health {fact:2, fact:3, fact:6}.
Facts (6)
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A Consensus Proposal for Nutritional Indicators to Assess ... - Frontiers frontiersin.org 1 fact
procedureThe 'Diet-Related Morbidity/Mortality Statistics' indicator uses two primary parameters: (1) the prevalence of individuals with physician-diagnosed obesity, cardiovascular diseases (CHD, stroke, hypertension), type II diabetes, osteoporosis, neurodegenerative diseases, and obesity-related cancers; and (2) disability-adjusted life years (DALYs) as a measure of disease burden associated with nutrition-related factors like high blood pressure, high cholesterol (total and LDL), and high blood sugar (insulin resistance/diabetes).
Chronic inflammation in the etiology of disease across the life span nature.com 1 fact
referenceSleep influences obesity, insulin resistance, and the risk of type 2 diabetes, according to a 2018 article by S. Reutrakul and E. Van Cauter in Metabolism: Clinical and Experimental.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
claimObesity is characterized by chronic, low-grade inflammation, which is considered an important contributor to the pathogenesis of insulin resistance.
Origins and evolution of the Western diet: health implications for the ... academia.edu 1 fact
referenceBoden G and Shulman GI defined the role of free fatty acids in obesity and type 2 diabetes, specifically regarding their role in the development of insulin resistance and beta-cell dysfunction, in a 2002 article in the European Journal of Clinical Investigation.
The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu 1 fact
claimObesity, insulin resistance, and type 2 diabetes increase the risk for heart disease.
Western diet – Knowledge and References - Taylor & Francis taylorandfrancis.com 1 fact
claimLong-term consumption of high-fat and high-carbohydrate foods, characteristic of the Western diet, is associated with obesity, insulin resistance, hypertriglyceridemia, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH), as well as inflammatory and oxidative stress conditions.