Serotonergic psychedelics ↔ psilocybin

Relations (1)

related 2.32 — strongly supporting 4 facts

Psilocybin is classified as a serotonergic psychedelic, as evidenced by its inclusion in studies of the class [1] and its shared mechanism of action on the 5-HT2A receptor [2]. Furthermore, both psilocybin and other serotonergic psychedelics are noted for their similar effects on cortical brain activity [3] and their potential to substitute for serotonin in specific physiological conditions [4].

Facts (4)

Sources

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 2 facts

claimThe psychedelic instrumentalization model predicts that psilocybin and other serotonergic psychedelics can substitute for 5-HT (serotonin) under conditions of tryptophan depletion, potentially ameliorating costs associated with impaired serotonergic neural signaling, such as depressed mood, increased stress vulnerability, and cognitive inflexibility.

referenceSerotonergic psychedelics, specifically LSD and psilocybin, increase the fractal dimension of cortical brain activity in both spatial and temporal domains, as reported in Neuroimage (2020).

Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature 1 fact

claimClassic serotonergic psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), primarily act on the 5-HT2A receptor.

The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Frontiers 1 fact

referenceA 2016 review by dos Santos et al. of 25 neuroimaging studies concluded that oral administration of serotonergic psychedelics, including mescaline, psilocybin, and ayahuasca, produces excitatory effects in the frontolateral/frontomedial cortex and medial temporal lobe areas, which are central to cognitive functioning, self-awareness, emotional processing, and memory.