Knowledge Tree
Serotonergic psychedelics
Also known as: Serotonergic psychedelic
Facts (19)
Sources
Psychedelics, Sociality, and Human Evolution frontiersin.org 5 facts
claimSerotonergic psychedelics provide homeostatic utility by substituting for 5-HT (serotonin) under circumstances in which endogenous biosynthesis and signaling functions are compromised.
claimThe psychedelic instrumentalization model predicts that psilocybin and other serotonergic psychedelics can substitute for 5-HT (serotonin) under conditions of tryptophan depletion, potentially ameliorating costs associated with impaired serotonergic neural signaling, such as depressed mood, increased stress vulnerability, and cognitive inflexibility.
referenceJ. Bouso, R. dos Santos, M. Alcazar-Corcoles, and J. Hallak conducted a systematic review of contemporary research on serotonergic psychedelics and personality in 2018.
claimSerotonergic psychedelics preferentially engage and functionally modulate the 5-HT2A receptor signaling pathway.
referenceSerotonergic psychedelics, specifically LSD and psilocybin, increase the fractal dimension of cortical brain activity in both spatial and temporal domains, as reported in Neuroimage (2020).
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 5 facts
claimSerotonergic psychedelic and ketamine experiences exhibit significant phenomenological overlap.
claimRecent neuroimaging research indicates that despite pharmacological differences, serotonergic psychedelics and ketamine share neural features, specifically heightened neural signal diversity, reduced within-network connectivity, and enhanced between-network connectivity.
referenceJohnston et al. provided an update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment involving ketamine and serotonergic psychedelics, published in Neuropharmacology in 2023.
claimThe use of calm, de-medicalized rooms reduces the distress associated with altered states of consciousness induced by serotonergic psychedelics and esketamine.
claimKetamine and serotonergic psychedelics are re-emerging as potential treatments for depression, generating considerable interest.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 3 facts
referenceA 2024 systematic review and meta-analysis published in Neuroscience and Biobehavioral Reviews examined the magnitude of long-term effects of serotonergic psychedelics on cognition, creativity, emotional processing, and personality.
referenceA 2025 study published in Schizophrenia Bulletin by Heller et al. investigates visual hallucinations in the context of serotonergic psychedelics and Lewy body diseases.
claimSerotonergic psychedelics are being explored as a potential treatment for personality disorders.
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 3 facts
claimClassic serotonergic psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), primarily act on the 5-HT2A receptor.
claimKetamine, 3,4-Methylenedioxymethamphetamine (MDMA), and ibogaine are psychoactive substances that hold promise for psychiatric treatment alongside classic serotonergic psychedelics.
claimSerotonergic psychedelics may treat depression through the mechanism of neuroplasticity.
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Sep 27, 2017 2 facts
referenceAlonso, J., Romero, S., Mañanas, M., and Riba, J. (2015) published 'Serotonergic psychedelics temporarily modify information transfer in humans' in the International Journal of Neuropsychopharmacology, volume 18, pages 1–9.
referenceA 2016 review by dos Santos et al. of 25 neuroimaging studies concluded that oral administration of serotonergic psychedelics, including mescaline, psilocybin, and ayahuasca, produces excitatory effects in the frontolateral/frontomedial cortex and medial temporal lobe areas, which are central to cognitive functioning, self-awareness, emotional processing, and memory.
Psychedelics and Consciousness: Distinctions, Demarcations, and ... ouci.dntb.gov.ua 1 fact
claimSerotonergic psychedelics induce altered states of consciousness and have shown potential for treating neuropsychiatric disorders, including depression and addiction.