Knowledge Tree
vitamin D
Facts (45)
Sources
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 34 facts
referenceYang CY, Leung PS, Adamopoulos IE, and Gershwin ME published a comprehensive review titled 'The implication of vitamin D and autoimmunity' in the journal Clinical Reviews in Allergy & Immunology in 2013.
claimVitamin D is suggested to have utility in preventing and treating autoimmune diseases and graft rejections because Th2 cells and regulatory T cells are important regulators in these conditions.
referenceAntico A, Tampoia M, Tozzoli R, and Bizzaro N published 'Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature' in Autoimmunity Reviews in 2012 (volume 12, issue 2, pages 127-136), providing a systematic review on Vitamin D supplementation and autoimmune diseases.
measurementAn estimated 1 billion people worldwide suffer from vitamin D deficiency or insufficiency.
referenceMora JR, Iwata M, and von Andrian UH published 'Vitamin effects on the immune system: vitamins A and D take centre stage' in Nature Reviews Immunology in 2008 (volume 8, issue 9, pages 685-698), which reviews the effects of vitamins A and D on the immune system.
referenceDuan S, Lv Z, Fan X, et al. published 'Vitamin D status and the risk of multiple sclerosis: a systematic review and meta-analysis' in Neuroscience Letters in 2014 (volume 570, pages 108-113), reporting on the relationship between Vitamin D status and multiple sclerosis risk.
claimDeficiencies or inadequacies of B vitamins and vitamins A, C, D, and E have been associated with obesity.
referenceDeluca HF and Cantorna MT published 'Vitamin D: its role and uses in immunology' in The FASEB Journal in 2001 (volume 15, issue 14, pages 2579-2585), reviewing the role and applications of Vitamin D in immunology.
referenceAgmon-Levin N, Theodor E, Segal RM, and Shoenfeld Y published 'Vitamin D in systemic and organ-specific autoimmune diseases' in Clinical Reviews in Allergy & Immunology in 2013 (volume 45, issue 2, pages 256-266), discussing the role of Vitamin D in autoimmune diseases.
referenceA 2013 meta-analysis by James E, Dobson R, Kuhle J, Baker D, Giovannoni G, and Ramagopalan SV published in Multiple Sclerosis examined the effect of vitamin D-related interventions on multiple sclerosis relapses.
claimA 2013 systematic review reported no effect of vitamin D supplementation on Multiple Sclerosis relapse.
referenceVitamin D application has evolved from rickets prophylaxis to general preventive healthcare, according to a 2013 update in Dermatoendocrinology.
referenceVitamin D induces the expression of the antimicrobial protein hCAP18 in human skin, according to a 2005 study in the Journal of Investigative Dermatology.
referenceDörr J, Ohlraun S, Skarabis H, and Paul F published a study protocol in 2012 in the journal Trials for a randomized controlled trial investigating the efficacy of vitamin D supplementation in patients with multiple sclerosis, known as the EVIDIMS Trial.
claimMacrophages produce the 25-hydroxyvitamin D3-1-hydroxylase enzyme, which allows for the local conversion of vitamin D to its active form.
referenceVitamin D plays a role in fighting infections, as discussed in a 2006 article in Nature Medicine.
referenceMunger KL and Ascherio A published an article in 2011 in the journal Multiple Sclerosis discussing the prevention and treatment of multiple sclerosis through the study of vitamin D effects.
claimLower exposure to ultraviolet-B radiation and the associated decrease in endogenous vitamin D synthesis are hypothesized to play a role in the pathology of autoimmune diseases.
referenceA 2012 meta-analysis by Song GG, Bae SC, and Lee YH published in Clinical Rheumatology examined the association between vitamin D intake and the risk of rheumatoid arthritis.
referenceVitamin D functions as more than a bone-related hormone, according to a 2003 review in Molecular Endocrinology.
referenceA 2013 meta-analysis of observational studies by Dong JY, Zhang WG, Chen JJ, Zhang ZL, Han SF, and Qin LQ published in Nutrients examined the relationship between vitamin D intake and the risk of type 1 diabetes.
referenceCantorna MT and Mahon BD published a review in 2004 in Experimental Biology and Medicine presenting evidence for vitamin D as an environmental factor affecting the prevalence of autoimmune diseases.
referencevan der Mei IA, Ponsonby AL, Dwyer T, et al. published a study in the Journal of Neurology in 2007 comparing vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia.
referenceToll-like receptor triggering initiates a vitamin D-mediated human antimicrobial response, according to a 2006 study in Science.
referenceMunger KL, Zhang SM, O'Reilly E, et al. published a study in Neurology in 2004 regarding vitamin D intake and the incidence of multiple sclerosis.
claimGenetic factors, such as VDR polymorphisms, and environmental factors, such as low UVB exposure and low dietary vitamin D intake, may contribute to low vitamin D status in autoimmune diseases.
claimVitamin D stimulates innate immunity components, including immune cell proliferation and cytokine production, which helps protect against infections.
referenceMerlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, and Saag KG reported in the Arthritis & Rheumatism journal in 2004 that vitamin D intake is inversely associated with rheumatoid arthritis, based on results from the Iowa Women's Health Study.
claimThe active form of vitamin D regulates the antimicrobial proteins cathelicidin and defensin.
referenceExtra-renal 1 alpha-hydroxylase plays a novel role in vitamin D-mediated barrier function, according to a 2004 study in Molecular and Cellular Endocrinology.
claimLow vitamin D intake is associated with an increased risk of Multiple Sclerosis (MS), Insulin-Dependent Diabetes Mellitus (IDDM), and Rheumatoid Arthritis (RA).
measurementA 2013 meta-analysis of five randomized controlled trials, involving 129 patients and 125 controls, found no significant effect of high-dose vitamin D supplements on the risk of relapse in Multiple Sclerosis patients.
referenceA 2001 birth-cohort study by Hyppönen E, Laara E, Reunanen A, Jarvelin MR, and Virtanen SM published in The Lancet investigated the intake of vitamin D and the risk of type 1 diabetes.
referencePozuelo-Moyano B, Benito-Leon J, Mitchell AJ, and Hernandez-Gallego J published a systematic review in Neuroepidemiology in 2013 of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis.
How do the indices based on the EAT-Lancet recommendations ... medrxiv.org May 14, 2024 2 facts
measurementThe EAT-Lancet Index (ELI), which uses semi-quantitative scores, shows positive associations with polyunsaturated fatty acids and vitamins D and E, but negative associations with protein, B-complex vitamins, phosphorus, calcium, and iron.
measurementThe HSDI and ELDS indices, which are based on binary scoring, correlated inversely with several nutrients including protein, DHA, EPA+DHA, riboflavin, niacin, pantothenic acid, vitamin B-6, vitamin B-12, vitamin D, iodine, phosphorus, zinc, calcium, and iron.
Comparison of Traditional Indigenous Diet and Modern Industrial ... isom.ca Feb 26, 2024 2 facts
claimThe traditional Inuit diet provided high levels of vitamin A and D through the consumption of liver organ meats, seal oil, whale blubber, and fish eyes and eggs.
claimThe processed diet consumed by some residents of Bethel, Alaska, consisted of white flour, white sugar, canned goods, coffee, and tea, and was inherently lacking in trace minerals and vitamins A, D, and C.
What Are The Global Impacts of The Western Diet On Health? rupahealth.com 2 facts
claimThe authors of the Rupa Health article claim that incorporating a Mediterranean diet and adding supplements such as Vitamin D and Reishi mushrooms can contribute to better metabolic health.
claimVitamin D is important for various physiological processes, including gene regulation, and low levels of this nutrient can negatively affect metabolic health.
Western Diet: How it affects health, risks, and complications medicalnewstoday.com Oct 27, 2023 2 facts
claimThe Standard American Diet (SAD) provides inadequate levels of micronutrients, which may lead to deficiencies in zinc and Vitamins A, C, D, and E.
measurementIn the U.S. population, the percentage of people with inadequate levels of key immune-related micronutrients is 45% for Vitamin A, 46% for Vitamin C, 95% for Vitamin D, 84% for Vitamin E, and 15% for Zinc.
Inflammation: Definition, Diseases, Types, and Treatment - WebMD webmd.com Jul 14, 2024 1 fact
claimSupplements that may have anti-inflammatory effects include omega-3 fatty acids, white willow bark, curcumin, green tea, capsaicin, magnesium, and vitamins B6, C, D, and E.
History of modern nutrition science—implications for current ... bmj.com Jun 13, 2018 1 fact
claimThe identification of vitamins in animal and human studies established the nutritional basis for deficiency diseases, leading to dietary strategies to address beriberi (vitamin B1), pellagra (vitamin B3), scurvy (vitamin C), pernicious anaemia (vitamin B12), and rickets (vitamin D).
Men and Women: Different to the Bone - El Camino Health elcaminohealth.org 1 fact
procedureThe recommended procedure for exercising safely includes: (1) talking to a doctor before starting an exercise program, (2) warming up and stretching to prevent muscle strain, (3) addressing leg alignment issues, potentially with orthotics, (4) adding resistance exercises to work large and small muscles, (5) maintaining healthy eating habits, including sufficient calcium and vitamin D intake, (6) training consistently with strength, flexibility, balance, and coordination exercises, and (7) working the core and lower body to protect the back and improve balance.