concept

nitrate

Facts (21)

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Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 17 facts

claimNitrate-mediated suppression of oxidative stress and maintenance of gut microbiome homeostasis prevents colon damage induced by total body irradiation.

claimIn a salivary gland radiation injury model of miniature pigs, nitrate increased the expression of sialin in acinar cells, promoting the entry of nitrate into cells, according to Feng et al. (2021b).

claimThe interaction between nitrate and sialin is typically accompanied by elevated sialin expression in important organs, which promotes various cellular biological functions.

claimThe interaction between nitric oxide (NO), nitrate, and the protein sialin constitutes an important mechanism for homeostasis regulation within the field of homeostatic medicine.

claimThrough the nitrate-nitrite-NO pathway, nitrate performs NO-like physiological functions including protecting the digestive system by increasing blood flow and regulating intestinal flora, alleviating obesity by adjusting fat metabolism, and assisting tumor therapy by increasing sensitivity to cisplatin chemotherapy.

procedureThe nitrate-nitrite-NO pathway involves the following steps: (1) nitrate is absorbed into the blood in the upper digestive tract after a meal; (2) approximately 25% of nitrate is absorbed by salivary glands and secreted into the oral cavity via saliva; (3) nitrate-reducing bacteria in the oral cavity reduce nitrate to nitrite; (4) nitrites are swallowed and reabsorbed into the blood; (5) various enzymes in the blood and tissues reduce nitrites to nitric oxide (NO).

claimDaily intake of nitrate restores liver metabolic capacity in d-galactose-induced aging mice and naturally aging mice by preventing liver cell aging and the degeneration of glucose and lipid metabolism, according to Wang et al. (2018).

claimNitrate upregulates the expression of cellular signaling pathways including MAPK, PI3K-Akt, mTOR, WNT, glutathione metabolism, and the cell cycle, which are involved in cell regeneration, cell metabolism, and disease progression.

claimExogenous nitrate intake can effectively maintain nitric oxide (NO) homeostasis when endogenous NO synthesis is impaired, such as in cases of endothelial dysfunction.

claimSialin is highly expressed in human salivary glands, and salivary gland function is a significant factor in the physiological function of nitrate, as reported by Qu et al. (2016).

claimSialin acts as a key protein for nitrate entry into cells and participates in the regulation of nitric oxide (NO) production and body homeostasis.

claimNitrate is an important substance that regulates nitric oxide (NO) homeostasis through the nitrate-nitrite-NO pathway.

claimThe mutual effects of sialin and nitrate are beneficial for maintaining nitric oxide (NO) homeostasis and improving systemic homeostasis.

referenceHu L, Jin L, Xia D, Zhang Q, Ma L, Zheng H, et al. published 'Nitrate ameliorates dextran sodium sulfate-induced colitis by regulating the homeostasis of the intestinal microbiota' in Free Radical Biology and Medicine in 2020, demonstrating the role of nitrate in regulating intestinal microbiota homeostasis.

referenceQu XM et al. investigated the role of salivary glands and oral bacteria in the conversion of nitrate to nitric oxide in a 2016 study published in the Journal of Dental Research.

claimSialin interacts with nitrate and participates in the regulation of nitric oxide (NO) production and cell biological functions for body homeostasis.

claimSialin functions as a nitrate transporter in mammalian cell membranes and plays a key role in the beneficial effects of nitrate and the maintenance of nitric oxide (NO) homeostasis, according to Qin et al. (2012).

An ethnobotanical study on wild edible plants in Taishan County ... frontiersin.org Frontiers Jul 10, 2025 4 facts

referenceA 2004 study by Qiu and Zeng analyzed the nitrate, nitrite, and vitamin C content of six edible wild vegetables belonging to the Amaranthaceae family.

referenceA 2005 study by Qiu and Zeng analyzed the nitrate, nitrite, and vitamin C content of eight edible wild vegetables in Guangdong, China.

measurementA 2004 study by Qiu and Zeng measured the concentrations of nitrate, nitrite, and vitamin C in six species from the Amaranthaceae family: Celosia argentea L., Amaranthus spinosus L., A. cruentus L., Alternanthera philoxeroides (Mart.) Griseb., A. viridis L., and A. tricolor L.

measurementA 2005 study by Qiu and Zeng analyzed the concentrations of nitrate, nitrite, and vitamin C in eight wild vegetable species from the Asteraceae family: Crassocephalum crepidioides (Benth.) S. Moore, Emilia sonchifolia (L.) DC., Sonchus wightianus DC., Lactuca sibirica (L.) Benth. ex Maxim., Elephantopus scaber L., Erigeron canadensis L., Artemisia argyi H. Lév. & Vaniot, and A. lactiflora Wall. ex DC.