concept

interleukin-1β

Also known as: IL-1β, Interleukin-22, Interleukin-37, Interleukin-38, IL-22, IL-37, IL-1F7, IL-38, IL-1F10, IL-1, interleukin-1 beta, interleukin-Iβ

Facts (14)

Sources

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 5 facts

claimInterleukin-22 (IL-22) is an anti-inflammatory cytokine produced by activated T-cells and NK cells that acts on stromal and epithelial cells via the IL-22R receptor to stimulate cell survival and proliferation.

claimThe interleukins IL-10, IL-37, and IL-38 regulate inflammation by suppressing innate and acquired immunity through binding to inhibitory receptors such as IL-18Ra (IL-R5) and IL-1R6.

claimB cells and macrophages produce IL-38, which inhibits IL-1, IL-6, IL-17, IL-22, and TNF.

claimInterleukin-38 (IL-38/IL-1F10) is an anti-inflammatory cytokine produced by B cells and macrophages that binds to the IL-1R1 receptor.

claimInterleukin-37 (IL-37/IL-1F7) is an anti-inflammatory cytokine produced by B-cells, NK cells, and monocytes that binds to CD218a (IL-18Ra) and potentially SIGGR, and is believed to act as a negative regulator inside the cell by interacting with SMAD3 activated downstream of TGFβ activity.

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 3 facts

referenceProinflammatory cytokines, including interleukin-1, tumor necrosis factor-α, and interleukin-6, possess somnogenic and pyrogenic properties and are linked to postdialytic symptoms such as daytime sleepiness and sleep disturbances (Konsman et al., 2002; Raison and Miller, 2001; Capuron et al., 2002).

claimInterleukin-1, tumor necrosis factor-α, and interleukin-6 are proinflammatory cytokines involved in hemodialysis-related symptoms, as identified by Pertosa et al. (2000).

referenceInterleukin-1, tumor necrosis factor-α, and interleukin-6 are identified as the major proinflammatory cytokines involved in the inflammatory response to hemodialysis (Pertosa et al., 2000).

The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu Vanderbilt University Feb 10, 2015 2 facts

claimWhite blood cells proliferate when binding to inflammatory cytokines, specifically interleukin 4 (IL-4) and interleukin 13 (IL-13).

claimOverproduction of interleukin 4 and interleukin 13 can trigger asthma attacks.

Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 2 facts

claimDetecting pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) is an expensive method that may identify specific factors causing chronic inflammation, though these assays are not standardized.

claimCherries and cherry juice consumption has been shown to be uricosuric and inhibitory for interleukin-1 (IL-1) in patients with gout.

How do the indices based on the EAT-Lancet recommendations ... medrxiv.org medRxiv May 14, 2024 1 fact

claimThe Dietary Inflammatory Index (DII) was developed based on a literature review identifying 45 dietary parameters associated with six inflammatory biomarkers: interleukin (IL)-1β, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)-α, and C-reactive protein.

EBM Tools for Practice: Best Biomarkers for Inflammation lipid.org National Lipid Association 1 fact

claimEpidemiologic studies primarily focus on downstream markers of inflammation, such as C-reactive protein (CRP) and fibrinogen, while a significant body of evidence also involves the interleukin-Iβ/interleukin-6 (IL-Iβ/IL-6) axis.