concept

induced pluripotent stem cells

Also known as: iPSCs, iPSC, iPS cells

Facts (38)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 21 facts

claimThe discovery of epidermal cell de-differentiation into stem cells and somatic cell reprogramming into induced pluripotent stem cells (iPSCs) demonstrated that cell fate is not a one-way process.

claimMelanoma cells, hepatoma cells, colorectal cancer cells, lung adenocarcinoma cells, and gastrointestinal cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs) through the induction of pluripotency-associated transcription factors, and these cancer-derived iPSCs maintain benignity without forming visible tumors in vivo.

referenceGobel et al. (2018) report that interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells, as published in Scientific Reports.

referenceLe et al. (2014) report enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells, as published in Cell Stem Cell.

referenceLapasset et al. (2022) published 'Cancer cells as a new source of induced pluripotent stem cells' in Stem Cell Research & Therapy, exploring the potential of cancer cells for reprogramming.

referenceWang et al. (2012) provide molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells in the journal Cell Research.

claimInduced pluripotent stem cells serve as a tool to study skeletal dysplasias and cartilage-related pathologic conditions, according to Liu et al. in Osteoarthritis and Cartilage (2017).

claimiPSC-derived LewisX+CXCR4+beta1-integrin+ neural stem cells improve the amyotrophic lateral sclerosis phenotype by preserving motor neurons and muscle innervation in human and rodent models, according to Nizzardo et al. in Human Molecular Genetics (2016).

claimTrabecular meshwork stem cells (TMSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) have demonstrated efficacy in maintaining intraocular pressure (IOP) equilibrium and restoring trabecular meshwork (TM) cellularity.

claimEctopic expression of the gene FOXN1 directs induced pluripotent stem cells (iPSCs) toward a thymus fate, creating FOXN1-mediated iPSC-derived thymic epithelial progenitors (iPSC-TEPs) that support T cell development and functional regeneration of the human thymus.

claimThe removal of DNA methylation is a prerequisite for epigenetic rejuvenation and the generation of induced pluripotent stem cells (iPSCs).

referenceRohani et al. (2014) investigate whether the aging signature is a hallmark of induced pluripotent stem cells in the journal Aging Cell.

claimPartial reprogramming can reduce the epigenetic age of cells without causing a loss of cell identity, suggesting that full reprogramming into induced pluripotent stem cells (iPSCs) is not required to reverse the aging of somatic cells.

claimInduced pluripotent stem cell (iPSC)-based treatment of age-related macular degeneration requires more than blind faith to succeed, according to Li, Hu, and He in Genes & Diseases (2017).

claimStem cell sources implicated in Parkinson’s disease treatment include neural stem cells, human embryonic stem cells, induced pluripotent stem cells, and directly induced dopamine neurons.

referenceHysolli et al. (2011) published 'DNA methylation dynamics in human induced pluripotent stem cells over time' in PLoS Genetics, analyzing how DNA methylation patterns change in iPSCs.

referenceHockemeyer and Jaenisch (2016) discuss the intersection of induced pluripotent stem cells and genome editing in the journal Cell Stem Cell.

referenceOh et al. (2019) reported the de novo generation of a functional human thymus from induced pluripotent stem cells.

claimLin et al. reported that microRNA-302s can convert skin cancer cells into iPSCs, resulting in decreased tumorigenicity and genomic demethylation, with these pluripotent cancer cells displaying more than 86% gene expression similarity to human embryonic stem cell (ESC) lines.

referenceInduced pluripotent stem cells face present and future challenges.

claim5-Azacytidine facilitates the reprogramming of human fibroblasts into induced pluripotent stem cells (iPSCs) by overcoming epigenetic barriers.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 14 facts

claimMetabolism-driven chromatin regulation is crucial for cellular plasticity, which dictates the changes required to modulate cellular identity during cancer transformation and reprogramming to induced pluripotent stem cells (iPSCs).

claimReprogramming to induced pluripotent stem cells (iPSCs) is significantly improved under high-glucose conditions, which support a non-fused mitochondrial network.

claimLow oxygen conditions increase the glycolytic flux of embryonic stem cells (ESCs) and improve the derivation of induced pluripotent stem cells (iPSCs).

claimSirtuins contribute to cell fate transition and have been implicated in enhancing the generation of induced pluripotent stem cells (iPSCs).

claimWhile a glycolytic switch is necessary to acquire pluripotency, the early phases of induced pluripotent stem cell (iPSC) generation are characterized by an initial increase in oxidative phosphorylation (OXPHOS) activity and the up-regulation of respiratory chain (RC) complexes.

claimWahlestedt et al. (2014) found that somatic cells with a heavy mitochondrial DNA mutational load produce induced pluripotent stem cells that exhibit distinct differentiation defects, as reported in 'Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects' published in Stem Cells.

claimMitochondrial DNA (mtDNA) mutagenesis impairs the derivation of induced pluripotent stem cells (iPSCs).

claimThe activation of dynamin-related protein 1 (DRP1), which regulates mitochondrial fission, is critical for reprogramming cells to induced pluripotent stem cells (iPSCs).

referenceLee et al. (2012) demonstrated that Sirtuin 1 facilitates the generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR‐34a and p53 pathways.

claimThe metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis during induced pluripotent stem cell (iPSC) generation is similar to the "Warburg effect" or "aerobic glycolysis" described by Otto Warburg in cancer cells, where cells maintain high glycolytic rates even in the presence of oxygen.

measurementInduced pluripotent stem cells (iPSCs) were discovered in 2006.

claimThe use of various antioxidants failed to increase the efficiency of induced pluripotent stem cell (iPSC) reprogramming and did not ameliorate growth defects in iPSCs carrying mitochondrial DNA (mtDNA) mutations.

referenceYoshida et al. (2009) reported that hypoxic conditions enhance the generation of induced pluripotent stem cells.

claimMitochondria in induced pluripotent stem cells (iPSCs) acquire a non-fused morphology with underdeveloped cristae during the induction of pluripotency.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 2 facts

claimHuman induced pluripotent stem cells (iPSCs), which are reprogrammed from a patient’s somatic cells, allow for personalized research that captures a patient’s specific genetic background while avoiding the ethical concerns associated with embryonic stem cells.

claimRecent research into stress adaptation mechanisms utilizes technologies including multi-omics approaches, induced pluripotent stem cells (iPSCs), and organoid technology.

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 1 fact

claimStanslowsky N, Jahn K, Venneri A, Naujock M, Haase A, Martin U, Frieling H, and Wegner F investigated the functional effects of cannabinoids during the dopaminergic specification of human neural precursors derived from induced pluripotent stem cells in 2017.