Fisetin is a selective senolytic candidate with low hematological toxicity that activates SIRT1 to block inflammatory responses in osteoarthritis (OA) chondrocytes and is currently in clinical trials (NCT04210986).

Authors

• Person: Not available Organization: Nature
  Cellular rejuvenation: molecular mechanisms and potential ... - Nature

Sources

• Cellular rejuvenation: molecular mechanisms and potential ... - Nature www.nature.com Nature via serper

Referenced by nodes (2)

• SIRT1 concept
• osteoarthritis concept