concept

SIRT1

Also known as: SIRT6, SIRT7, SIRT2, SIRT3, Sirtuin 1

Facts (18)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 10 facts

referenceSIRT1 and SIRT6 play roles in aging-related diseases, according to You and Liang in a 2023 review in Biochimica et Biophysica Acta - Molecular Basis of Disease.

referenceZhu et al. (2021) reported in Frontiers in Cell and Developmental Biology that N6-methyladenosine induced miR-34a-5p promotes TNF-α-induced nucleus pulposus cell senescence by targeting SIRT1.

referenceThe article 'Metformin protects human lens epithelial cells from high glucose-induced senescence and autophagy inhibition by upregulating SIRT1' published in Graefe's Archive for Clinical and Experimental Ophthalmology in 2024 (262:477–85) states that metformin protects human lens epithelial cells from high glucose-induced senescence and autophagy inhibition by upregulating SIRT1.

referenceHu S. and Wang S. published 'The role of SIRT3 in the osteoporosis' in Frontiers in Endocrinology in 2022, investigating the function of SIRT3 in bone health.

referenceLiu F. et al. published 'S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis' in Pharmacological Research in 2023, identifying S-sulfhydration of SIRT3 as a mechanism to improve bone marrow mesenchymal stem cell (BMSC) health.

referenceThe article 'Redox regulation of SIRT1 in inflammation and cellular senescence' published in Free Radical Biology and Medicine in 2013 (61:95–110) explores the redox regulation of SIRT1 during inflammation and cellular senescence.

referenceC. Chen, M. Zhou, Y. Ge, and X. Wang published 'SIRT1 and aging related signaling pathways' in Mechanisms of Ageing and Development in 2020, which reviews the relationship between SIRT1 and various aging-related signaling pathways.

claimThe protein hnRNP A1 antagonizes cellular senescence and the senescence-associated secretory phenotype by regulating the stability of SIRT1 mRNA.

referenceLu et al. (2021) reported in Cell Death & Disease that METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1.

referenceSIRT1-FOXOs activity regulates diabetic complications, as reported by Jalgaonkar et al. in a 2022 study in Pharmacological Research.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 4 facts

referenceSIRT7 plays a role in the aging process, as detailed in a 2022 review by Lagunas-Rangel in Cellular and Molecular Life Sciences.

claimFisetin is a selective senolytic candidate with low hematological toxicity that activates SIRT1 to block inflammatory responses in osteoarthritis (OA) chondrocytes and is currently in clinical trials (NCT04210986).

referenceSirt1, a class III histone deacetylase, induces autophagy to prevent prion peptide neurotoxicity, according to Jeong et al. in Neurobiology of Aging (2013).

referenceFisetin inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice, as reported by Wang et al. in International Immunopharmacology (2017).

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 3 facts

referenceTang et al. (2017) established that methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.

referenceLee et al. (2012) demonstrated that Sirtuin 1 facilitates the generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR‐34a and p53 pathways.

referenceSharma et al. (2013) investigated the role of the SIRT6 protein in the aging and reprogramming of human induced pluripotent stem cells.

Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 1 fact

claimSilymarin partially reduces UV-induced apoptosis by activating the Akt, SIRT1, and MAPK pathways, according to Cheon [109].