concept

osteoarthritis

Also known as: OA

Facts (24)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 14 facts

claimSenolytic agents and senomorphic therapy are potential treatments for osteoarthritis (OA).

claimNavitoclax and UBX0101 are potential senolytic agents for alleviating osteoarthritis (OA), and the clinical trial for UBX0101 (NCT03513016) has been completed.

referenceThe suppression of the circadian clock protein cryptochrome 2 promotes osteoarthritis, as reported by Bekki et al. in Osteoarthritis and Cartilage in 2020.

claimOsteoarthritis (OA) is a degenerative disease of the cartilage that develops with aging and shares a pathogenesis with the Senescence-Associated Secretory Phenotype (SASP) and senescence of joint tissue cells.

claimMMP13 is a critical target gene during the progression of osteoarthritis.

claimThe expression of the CLOCK protein is increased in osteoarthritis cartilage.

claimFisetin is a selective senolytic candidate with low hematological toxicity that activates SIRT1 to block inflammatory responses in osteoarthritis (OA) chondrocytes and is currently in clinical trials (NCT04210986).

referenceMechanisms and therapeutic implications of cellular senescence in osteoarthritis were reviewed by Zheng et al. in Nature Reviews Rheumatology (2021).

referenceThe extracellular matrix plays a central role in aging and osteoarthritis, according to Rahmati et al. in their research.

claimSenomorphic agents that target matrix metalloproteinases (MMPs) reduce osteoarthritis (OA) symptoms, increase type II collagen, and inhibit chondrocyte degeneration in wild-type (WT) mice.

claimAblation of the CLOCK protein in osteoarthritis cartilage increases antioxidant enzyme activity, lowers reactive oxygen species generation, and alleviates chondrocyte senescence by reestablishing autophagic flow.

claimSuppression of the CRY2 gene, which is a downstream gene of the CLOCK-BMAL1 complex, contributes to the loss of extracellular matrix homeostasis in cartilage in mice with ageing-related osteoarthritis.

claimUrolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis, according to a 2022 study in Aging Cell.

referenceFisetin inhibits IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice, as reported by Wang et al. in International Immunopharmacology (2017).

Medicinal plants: bioactive compounds, biological activities ... frontiersin.org Frontiers in Immunology 2 facts

claimMethanol extract of sweet cherry fruit is conventionally employed to alleviate osteoarthritis and address cardiovascular illnesses.

claimMethanol extract from sweet cherry fruit is used in the treatment of cancer, osteoarthritis, and cardiovascular disease, and shows activity against Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 2 facts

referenceYe G, Li J, Yu W, Xie Z, Zheng G, Liu W et al. reported in Experimental & Molecular Medicine (2023) that ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate mesenchymal stem cell (MSC) senescence and osteoarthritis progression.

referenceLin, S., Wu, B., Hu, X., Lu, H. (2024) found that Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis by mediating mitochondrial dysfunction, as published in the International Journal of Biological Sciences.

A Comprehensive Review on the Therapeutic Properties of ... traditionalmedicine.actabotanica.org Acta Botanica 2 facts

claimGinger possesses anti-inflammatory properties that can help reduce pain and inflammation associated with conditions like osteoarthritis.

claimGinger (Zingiber officinale) extract and ibuprofen have been compared for their effects on patients with osteoarthritis, according to a 2005 study.

Men and Women: Different to the Bone - El Camino Health elcaminohealth.org El Camino Health 1 fact

claimWomen are more susceptible to overuse injuries, such as stress fractures or repeat ankle sprains, and have a higher incidence of osteoarthritis, tendonitis, and carpal tunnel syndrome compared to men.

Difference between Male and Female Bones - BYJU'S byjus.com BYJU'S 1 fact

claimMales are less prone to bone diseases, while females are more prone to bone diseases such as osteoarthritis and osteopenia.

Inflammation: Definition, Diseases, Types, and Treatment - WebMD webmd.com WebMD Jul 14, 2024 1 fact

claimOsteoarthritis is a degenerative disorder characterized as a "wear and tear" issue, rather than an autoimmune disease.

Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu Linus Pauling Institute 1 fact

claimObesity is associated with an increased risk of morbidity from chronic diseases, including hypertension, cardiovascular disease, type 2 diabetes mellitus, liver and gallbladder disease, osteoarthritis, sleep apnea, and certain cancers.