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related 0.60 — strongly supporting 6 facts
Psilocybin directly modulates amygdala activity during emotional processing, as shown by increased amygdala responses to emotional faces in treatment-resistant depression patients [1], [2], [3], decreased amygdala response to negative stimuli in healthy subjects [4], reduced top-down modulation from amygdala to visual cortex [5], and correlations between amygdala blood flow changes and depression scores [6].
Facts (6)
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Neuroimaging in psychedelic drug development: past, present, and ... nature.com 3 facts
claimThe first open-label study of psilocybin for treatment-resistant depression showed that changes in cerebral blood flow in the amygdala, measured with arterial spin-labelling MRI, correlated with changes in depression scores.
claimResearch on the cohort from the first open-label psilocybin study for treatment-resistant depression found increased amygdala responses to emotional stimuli, that changes in amygdala connectivity predict some clinical outcomes, and that patients show increased brain response to music stimuli following treatment.
referenceRoseman et al. (2018) observed increased amygdala responses to emotional faces in patients after receiving psilocybin for treatment-resistant depression.
Psychedelics, Sociality, and Human Evolution frontiersin.org 1 fact
measurementHealthy subjects (n=12) experienced enhanced emotional self-control and tolerance, decreased negative mood, increased positive mood, and decreased amygdala response to negative affective stimuli after psilocybin administration, according to Barrett et al. (2020).
Psychedelics and Consciousness: Distinctions, Demarcations, and ... ouci.dntb.gov.ua 1 fact
claimLeor Roseman et al. observed increased amygdala responses to emotional faces after psilocybin treatment for treatment-resistant depression, published in Neuropharmacology, volume 142, page 263.
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org 1 fact
claimPsilocybin produces a shift in emotional biases toward positive stimuli by decreasing visual threat processing, which is achieved by reducing the modulation caused by top-down connections from the amygdala to the primary visual cortex.