psychedelic effects ↔ default mode network

Relations (1)

related 2.00 — strongly supporting 3 facts

The Default Mode Network is linked to psychedelic effects as its interruption or decreased activity is hypothesized to be a primary neural mechanism underlying the altered states of consciousness induced by psychedelics, as evidenced by [1], [2], and [3].

Facts (3)

Sources

The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Frontiers 3 facts

referenceBarrett and Griffiths (2017) identified parallels in the neural bases of psychedelic and meditative effects on the Default Mode Network (DMN), specifically hypothesizing that visionary experiences result from decreased activity and functional connectivity in the medial nodes of the DMN (PCC and MPFC), which mediate self-referential processing.

claimDos Santos et al. (2016) noted that variations in study results regarding psychedelic effects on the Default Mode Network may be attributed to differences in the phase of the experience studied, drug dosage, measurement time-scales, and the route of administration (oral vs. intravenous).

claimThe interruption of the Default Mode Network (specifically the posterior cingulate cortex) by meditation, hypnosis, and epilepsy necessitates a general explanation for psychedelic effects within the broader context of altered consciousness.