Knowledge Tree
Relations (1)
related 3.17 — strongly supporting 8 facts
Insulin resistance is a core pathophysiological mechanism in the development of type 2 diabetes, as evidenced by its role in glucose metabolism [1], [2] and its association with obesity and beta-cell dysfunction [3]. Furthermore, clinical research highlights that mitigating insulin resistance is a primary therapeutic goal for managing type 2 diabetes [4], and both conditions are frequently linked as comorbid risk factors for heart disease [5] and metabolic syndrome [6], [7].
Facts (8)
Sources
A Consensus Proposal for Nutritional Indicators to Assess ... - Frontiers frontiersin.org 1 fact
procedureThe 'Diet-Related Morbidity/Mortality Statistics' indicator uses two primary parameters: (1) the prevalence of individuals with physician-diagnosed obesity, cardiovascular diseases (CHD, stroke, hypertension), type II diabetes, osteoporosis, neurodegenerative diseases, and obesity-related cancers; and (2) disability-adjusted life years (DALYs) as a measure of disease burden associated with nutrition-related factors like high blood pressure, high cholesterol (total and LDL), and high blood sugar (insulin resistance/diabetes).
Chronic inflammation in the etiology of disease across the life span nature.com 1 fact
referenceSleep influences obesity, insulin resistance, and the risk of type 2 diabetes, according to a 2018 article by S. Reutrakul and E. Van Cauter in Metabolism: Clinical and Experimental.
Why Is Sleep Important for Our Mental and Physical Health? insightspsychology.org 1 fact
claimSleep deprivation affects the body's ability to metabolize sugar, which increases the risk of developing insulin resistance and type 2 diabetes.
Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov 1 fact
claimThe activation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and adipocytes due to Obstructive Sleep Apnea (OSA) leads to the release of catecholamines, cortisol, and inflammatory cytokines, which may mediate the development of glucose intolerance, insulin resistance, and type 2 diabetes.
Long-Term Effects of Chronic Sleep Deprivation empowersleep.com 1 fact
claimChronic sleep deprivation causes insulin resistance by affecting the body's ability to metabolize glucose, thereby increasing the risk of type 2 diabetes.
Origins and evolution of the Western diet: health implications for the ... academia.edu 1 fact
referenceBoden G and Shulman GI defined the role of free fatty acids in obesity and type 2 diabetes, specifically regarding their role in the development of insulin resistance and beta-cell dysfunction, in a 2002 article in the European Journal of Clinical Investigation.
The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu 1 fact
claimObesity, insulin resistance, and type 2 diabetes increase the risk for heart disease.
Medicinal plants and human health: a comprehensive review of ... link.springer.com 1 fact
claimBioactive compounds derived from garlic, onion, and Andrographis paniculata mitigate insulin resistance in patients with type 2 diabetes by decreasing cellular inflammation and augmenting insulin signaling pathways.