obstructive sleep apnea ↔ hypothalamic-pituitary-adrenal axis

Relations (1)

related 2.00 — strongly supporting 3 facts

Obstructive sleep apnea (OSA) is linked to the hypothalamic-pituitary-adrenal axis because the intermittent hypoxia and sleep fragmentation characteristic of OSA stimulate this axis [1], [2]. This activation subsequently triggers the release of cortisol and other mediators that contribute to metabolic dysfunction [3].

Facts (3)

Sources

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 3 facts

claimThe activation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and adipocytes due to Obstructive Sleep Apnea (OSA) leads to the release of catecholamines, cortisol, and inflammatory cytokines, which may mediate the development of glucose intolerance, insulin resistance, and type 2 diabetes.

claimThe biochemical cascade by which Obstructive Sleep Apnea (OSA) disrupts glucose metabolism begins with intermittent hypoxia and recurrent sleep arousals (sleep fragmentation), which stimulate the sympathetic nervous system, the hypothalamic-pituitary-adrenal axis, and adipocytes.

claimPunjabi and Beamer (2005) describe the biochemical cascade of obstructive sleep apnea (OSA) as beginning with intermittent hypoxia and recurrent sleep fragmentation, which stimulates the sympathetic nervous system, the hypothalamic-pituitary-adrenal axis, and adipocytes.