Knowledge Tree
Relations (1)
related 3.17 — strongly supporting 8 facts
The prefrontal cortex and the default mode network are functionally linked as key components of higher-level cognitive integration and self-referencing processes, which are simultaneously disrupted during altered states of consciousness as described in [1], [2], [3], and [4]. Their combined compromise is central to the emergence of non-ordinary experiences, as noted in [5] and [6].
Facts (8)
Sources
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org 8 facts
claimPsychedelic experiences do not typically manifest operators that depend on higher-level cognitive integration provided by the prefrontal cortex (PFC) or the self and autobiographical qualities maintained by the Default Mode Network (DMN).
claimVisionary experiences across diverse modes of altering consciousness share a common mechanism released by the interruption of the prefrontal cortex (PFC) and the default mode network (DMN).
claimThe common mechanisms underlying diverse alterations of consciousness involve the disruption of normal functions in the prefrontal cortex and the default mode network (DMN).
claimPsychedelics and other processes that alter consciousness share common mechanisms involving the disabling of the prefrontal cortex and default mode networks.
claimEgoless experiences, measured as 'oceanic boundlessness,' are associated with alterations in the frontolimbic-parieto-striatal network and are positively correlated with cerebral glucose metabolism in Default Mode Network regions (anterior cingulate cortex, hippocampus, inferior parietal cortex) and prefrontal cortex areas (frontomedial superior, frontolateral, and left inferolateral).
claimPositive emotional experiences and profound quiescence of meditative practices result from a deafferentation of limbic stimulation from the peripheral parasympathetic system, combined with reverberating parietal lobule connections with Prefrontal Cortex (PFC) circuits that result in stimulation of both divisions of the Autonomic Nervous System and enhanced connections of the sensory association areas with the inferior parietal lobe, a key Default Mode Network (DMN) area.
claimThe disruption of top-down control mediated by the prefrontal cortex (PFC) and the compromise of self-referencing processes in the default mode network (DMN) leads to the emergence of processes from lower-level brain systems, which manifest as innate intelligences, modules, and operators.
claimPsychedelics, meditation, hypnosis, and epilepsy all cause an interruption of ordinary brain control processes by compromising the integrity of the Default Mode Network (DMN) and its connectivity with other brain areas, particularly the prefrontal cortex (PFC).