Knowledge Tree

Relations (1)

related 2.32 — strongly supporting 4 facts

IFN-gamma is a cytokine that directly induces the activation of macrophages as described in [1], [2], and [3], while macrophages themselves are involved in the production of cytokines that regulate IFN-gamma levels as noted in [4].

Facts (4)

Sources

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 4 facts

claimInterferon-gamma (IFN-γ) is a pro-inflammatory cytokine produced by T Cells and NK cells that binds to CDw119 (IFNG R1) and functions in anti-viral defense, macrophage activation, increasing neutrophil and monocyte function, and regulating MHC-I and -II expression.

claimThe release of IFN-γ or TNF-α during a cytokine storm leads to the activation of macrophages, dendritic cells, other immune cells, and endothelial cells.

procedureIn the pathogenesis of a cytokine storm, the activation of T cells or the lysis of immune cells induces the release of IFN-γ or TNF-α, which subsequently activates macrophages, dendritic cells, other immune cells, and endothelial cells.

referenceIL-18 is classified as a pro-inflammatory cytokine, is produced by macrophages, dendritic cells, and epithelial cells, binds to the CD218a (IL-18Ra) receptor, targets monocytes and T cells, and functions in recruiting monocytes and T lymphocytes, synergizing with IL-12 to induce IFN-gamma production, and inhibiting angiogenesis.