concept

IFN-gamma

Also known as: IFN-gamma, IFN-γ, interferon-gamma

Facts (13)

Sources

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 7 facts

claimInterferon-gamma (IFN-γ) is a pro-inflammatory cytokine produced by T Cells and NK cells that binds to CDw119 (IFNG R1) and functions in anti-viral defense, macrophage activation, increasing neutrophil and monocyte function, and regulating MHC-I and -II expression.

claimThe release of IFN-γ or TNF-α during a cytokine storm leads to the activation of macrophages, dendritic cells, other immune cells, and endothelial cells.

claimIn the context of SARS-CoV-2 infection, the cytokines IL-12 and IL-8 enhance IFN-γ production, which attracts monocytes and T lymphocytes, but not neutrophils, to induce apoptosis and eliminate infected cells.

claimPro-inflammatory cytokines include IL-1, IL-2, IL-12, IL-17, IL-18, IFN-γ, and TNF-α.

procedureIn the pathogenesis of a cytokine storm, the activation of T cells or the lysis of immune cells induces the release of IFN-γ or TNF-α, which subsequently activates macrophages, dendritic cells, other immune cells, and endothelial cells.

claimThe activation of T-helper cells releases a wave of IL-6, IFN-γ, MCP1, and IP-10 (CXCL10) into circulation.

referenceIL-18 is classified as a pro-inflammatory cytokine, is produced by macrophages, dendritic cells, and epithelial cells, binds to the CD218a (IL-18Ra) receptor, targets monocytes and T cells, and functions in recruiting monocytes and T lymphocytes, synergizing with IL-12 to induce IFN-gamma production, and inhibiting angiogenesis.

3. The Innate Immune System - Immunopaedia immunopaedia.org.za Immunopaedia 3 facts

claimPlasmacytoid dendritic cells produce type I interferons (identified in the source as IFN-γ and IFN-γ) during viral infections, driven by activation via endosomal TLR7 and TLR9 pathways.

claimNatural Killer (NK) cells stimulate inflammatory responses by secreting IFN-gamma, TNF-alpha, GM-CSF, and chemokines including CCL4, CCL5, and CCL22.

claimUpon antigen activation, Mucosa-associated invariant T (MAIT) cells produce IFN-gamma, IL-4, IL-5, and IL-10.

Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Frontiers Jul 1, 2024 1 fact

claimTherapeutic immunosuppressive strategies to reduce IFN or IFN-related pathway signaling are associated with an increased risk of malignancy and infection.

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 1 fact

measurementGinsenoside Rg1 enhances Th1 cytokine production (IFN-γ, IL-2) by 40–70% while diminishing Th2 cytokines (IL-4, IL-5) by 30–50% in allergen-sensitized mice.

Bioelectricity - The Levin Lab drmichaellevin.org drmichaellevin.org 1 fact

referenceErndt-Marino, J., Yeisley, D. J., Chen, H., Levin, M., Kaplan, D. L., and Hahn, M. S. published a study in 2020 in Bioelectricity regarding the impact of ionic composition and osmolarity on interferon-gamma stimulated murine macrophages in vitro.