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Psilocybin is directly involved in clinical trials, as evidenced by the detailed protocol for its use at Johns Hopkins University in treating major depressive disorder [1] and approvals by governing bodies for such trials alongside other psychedelics [2].

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Sources
Ancient Roots of Today's Emerging Renaissance in ... link.springer.com Springer 1 fact
claimIn the last decade, governing bodies have approved clinical trials for MDMA, ketamine, LSD, psilocybin, and dimethyltryptamine.
History and Current Status of Psychedelics and Entactogens ... - NCBI ncbi.nlm.nih.gov Stroud C, Posey Norris SM, Matney C · National Academies Press 1 fact
procedureThe psilocybin clinical trial protocol at Johns Hopkins University for major depressive disorder includes preparatory visits with a facilitator, treatment sessions involving eyeshades and headphones with standardized music, and subsequent integrative sessions to process insights.