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Psilocybin is related to the anterior cingulate cortex because it acts upon this brain region to modulate pain and mood circuits as noted in [1], and its administration has been shown to alter neurochemical concentrations within this specific area in patients with major depressive disorder as described in [2].
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Neuroimaging in psychedelic drug development: past, present, and ... nature.com 1 fact
measurementAn open-label study of patients with major depressive disorder reported reductions in glutamate and N-Acetylaspartate concentrations in the anterior cingulate cortex, as measured by Magnetic Resonance Spectroscopy (MRS), following psilocybin treatment.
Psychedelic Drugs News - ScienceDaily sciencedaily.com 1 fact
claimUniversity of Pennsylvania researchers found that psilocybin can calm brain circuits tied to pain and mood by working in the anterior cingulate cortex, which eases both physical suffering and emotional distress in animal studies.