Knowledge Tree
Relations (1)
related 3.17 — strongly supporting 8 facts
Sleep duration and brain volume are linked through research demonstrating a quadratic relationship between them [1], where sleeping between six and eight hours is predictive of higher brain volume [2]. Furthermore, brain volume acts as a mediator in the relationship between sleep duration and executive function {fact:2, fact:5}.
Facts (8)
Sources
Impact of sleep duration on executive function and brain structure nature.com 8 facts
claimThe study demonstrated a quadratic relationship between sleep duration and brain volume in several brain regions, while other areas showed lower volume only with longer sleep durations.
procedureThe researchers investigated the association between sleep duration and brain volume by comparing individuals who sleep six-to-eight hours against those with other sleep durations (N = 37,553).
measurementThe mediation effect of brain volume on the relationship between sleep duration and executive function resulted in a significant drop in the beta value of a*b = 0.01 (p < 0.001).
claimSleeping between six and eight hours remained predictive of higher brain volume in a regression model that controlled for baseline sleep characteristics, obstructive sleep apnoea traits, smoking, vascular co-morbidity, APOE ε status, body mass index, and socio-economic status.
procedureResearchers used permutation testing to analyze brain volume differences by shuffling datapoints for two different sleep duration groups across brain regions, testing 1000 permuted datasets per region.
claimIn a sub-group of 37,898 individuals who underwent multi-modal brain imaging, researchers explored the relationship between sleep duration and brain volume.
claimSleeping between six and eight hours is significantly associated with higher executive function, and this relationship is partially mediated by brain volume in sleep-related regions.
measurementVolume in 56 brain regions significantly predicted executive function, while volume in 46 brain regions showed a significant quadratic relationship with sleep duration.