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Systemic inflammation is a specific manifestation of the broader concept of inflammation, as evidenced by the release of free fatty acids from hypertrophied adipose tissue which directly induces this state as described in [1].
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Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
claimHypertrophied adipose tissue contributes to an inflammatory state through four mechanisms: (1) altered adipokine secretion, specifically increased pro-inflammatory leptin and reduced anti-inflammatory adiponectin; (2) release of free fatty acids that induce systemic inflammation; (3) increased endoplasmic reticulum stress triggered by adipocyte expansion, leading to oxidative stress and inflammation; and (4) increased inflammatory gene expression and immune cell activation in hypoxic regions.