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Relations (1)
related 2.58 — strongly supporting 5 facts
Psilocybin is a psychedelic compound that acts as an agonist for the serotonin 2A receptor, as evidenced by its primary targeting of this receptor subtype [1] and the correlation between receptor occupancy and psilocybin's psychedelic effects [2]. Furthermore, the activation of these receptors is established as the underlying mechanism for psilocybin-induced visual and cognitive effects [3], [4].
Facts (5)
Sources
Psychedelics, Sociality, and Human Evolution frontiersin.org 2 facts
claimPsilocybin and similar psychedelics primarily target the serotonin 2A receptor subtype, which stimulates an active coping strategy response and promotes a flexible, associative mode of cognition.
claimKometer et al. (2013) established that the activation of serotonin 2A receptors underlies psilocybin-induced effects on alpha oscillations, N170 visual-evoked potentials, and visual hallucinations.
Neuroimaging in psychedelic drug development: past, present, and ... nature.com 2 facts
referenceStenbæk et al. (2021) found that brain serotonin 2A receptor binding predicts the subjective temporal and mystical effects of psilocybin in healthy humans.
referenceMadsen et al. (2019) found that the psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.
The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org 1 fact
claimWhile some experts define the term 'psychedelic' specifically as agonists of serotonin 2A receptors (such as psilocybin), psychedelic treatment models have been applied to diverse psychoactive drugs including MDMA, ibogaine, cannabis, and ketamine.