concept

serotonin 2A receptor

Also known as: serotonin 2A receptor, serotonin 2A receptors

Facts (10)

Sources

Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature Sep 27, 2023 4 facts

referenceEttrup et al. (2014) published a study in the Journal of Cerebral Blood Flow & Metabolism on serotonin 2A receptor agonist binding in the human brain using [11C]Cimbi-36.

referenceStenbæk et al. (2021) found that brain serotonin 2A receptor binding predicts the subjective temporal and mystical effects of psilocybin in healthy humans.

referenceMadsen et al. (2019) found that the psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.

referenceErritzoe et al. (2011) conducted in vivo imaging of cerebral serotonin transporter and serotonin 2A receptor binding in users of 3,4-methylenedioxymethamphetamine (MDMA or ‘Ecstasy’) and other hallucinogens.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 3 facts

claimPsilocybin and similar psychedelics primarily target the serotonin 2A receptor subtype, which stimulates an active coping strategy response and promotes a flexible, associative mode of cognition.

claimKraehenmann et al. (2017) reported that LSD increases primary process thinking through serotonin 2A receptor activation.

claimKometer et al. (2013) established that the activation of serotonin 2A receptors underlies psilocybin-induced effects on alpha oscillations, N170 visual-evoked potentials, and visual hallucinations.

The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org Frontiers Sep 27, 2017 1 fact

claimPsychedelic stimulation of excitatory cortical neurons with serotonin 2A receptors disrupts the normal rhythmic oscillations of cortical neurons, resulting in a decoupling between cells and an overall disorganization of cortical activity, as reported by Carhart-Harris et al. (2014a).

The Montreal model: an integrative biomedical-psychedelic ... frontiersin.org Frontiers in Psychiatry 1 fact

claimWhile some experts define the term 'psychedelic' specifically as agonists of serotonin 2A receptors (such as psilocybin), psychedelic treatment models have been applied to diverse psychoactive drugs including MDMA, ibogaine, cannabis, and ketamine.

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 1 fact

claimLSD-induced alterations in the neural response to dynamic changes in music are mediated by serotonin 2A receptor signaling.