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related 2.58 — strongly supporting 5 facts
Functional MRI is the primary neuroimaging technique used to study the neural mechanisms and brain connectivity changes induced by psilocybin, as evidenced by its use in clinical studies [1], [2], and [3], as well as in computational modeling of its effects [4] and PET-fMRI comparative research [5].
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Neuroimaging in psychedelic drug development: past, present, and ... nature.com 3 facts
claimAn open-label study of patients with major depressive disorder found that psilocybin treatment led to increased cognitive flexibility (measured by perseverative errors on a set-shifting task) and neural flexibility (measured by functional connectivity via fMRI) that persisted for up to four weeks post-treatment.
referenceCarhart-Harris et al. (2017) used fMRI to measure brain mechanisms associated with the use of psilocybin for treatment-resistant depression.
referenceR.L. Carhart-Harris, D. Erritzoe, T. Williams, J.M. Stone, L.J. Reed, A. Colasanti, et al. published 'Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin' in the Proceedings of the National Academy of Sciences USA in 2012.
A virtual clinical trial of psychedelics to treat patients with disorders ... eurekalert.org 1 fact
referenceAlnagger et al. published a study in the journal Advanced Science that utilized personalized computational models of patients' brains, constructed from individual functional MRI and diffusion-weighted imaging scans, to virtually simulate the effects of LSD and psilocybin on patients with disorders of consciousness.
Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org 1 fact
referenceSafron, A, Klimaj, V, Hipólito, I. published 'Human Cortical Serotonin 2A Receptor Occupancy by Psilocybin Measured Using [11C]MDL 100,907 Dynamic PET and a Resting-State fMRI-Based Brain Parcellation' in 'Frontiers in Neuroergonomics' in 2022.