concept

TGF-β

Also known as: TGFβs, TGFβ, Transforming growth factor-beta

Facts (10)

Sources

Wound Healing Phases - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov National Library of Medicine 2 facts

claimTransforming growth factor and other cytokines play a role in healing, but the optimal timing and dosage for clinical application are still being debated.

claimPlatelet-derived growth factor attracts fibroblasts and, in conjunction with transforming growth factor, enhances the division and multiplication of fibroblasts, which then synthesize collagen.

3. The Innate Immune System - Immunopaedia immunopaedia.org.za Immunopaedia 2 facts

claimActivated dendritic cells produce IL-12 family cytokines (IL-12, IL-23, and IL-27) which have Th1-cell polarizing capacity, as well as IL-6, IL-10, and TGF-β which have regulatory T cell polarizing effects.

referenceEosinophils participate in acute and chronic inflammatory reactions, particularly in allergic diseases, by producing leukotrienes (LT), platelet-activating factor (PAF), and cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, IL-5, IL-6, IL-8, TNF-α, and TGF-β.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 2 facts

claimHuang et al. (2022) found that low-dose IL-2 attenuated depression-like behaviors and pathological changes in a chronic stress-induced mouse model of depression by restoring the balances between IL-6 and TGF-β and between Th17 and Treg.

claimChronic unpredictable stress elevates serum corticosterone and serum IL-6 levels, while simultaneously causing microglia activation and a decrease in TGF-β.

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com Thermo Fisher Scientific 2 facts

claimTransforming growth factor-beta (TGF-β) is an anti-inflammatory cytokine produced by T cells and B cells that binds to TGF-βR1, 2, and 3, and acts on activated T and B cells to inhibit their proliferation, inhibit hematopoiesis, and promote wound healing.

claimInterleukin-37 (IL-37/IL-1F7) is an anti-inflammatory cytokine produced by B-cells, NK cells, and monocytes that binds to CD218a (IL-18Ra) and potentially SIGGR, and is believed to act as a negative regulator inside the cell by interacting with SMAD3 activated downstream of TGFβ activity.

The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov Feingold KR, Adler RA, Ahmed SF · National Center for Biotechnology Information Aug 5, 2018 1 fact

claimTransforming growth factor-beta affects steroidogenesis and the expression of key steroidogenic enzymes in a human ovarian thecal-like tumor cell model, according to a 1996 study by Carr et al. published in the American Journal of Obstetrics and Gynecology.

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 1 fact

procedureThe generation of thymic epithelial progenitors (TEPs) from human embryonic stem cells (hESCs) involves a two-step procedure: first, treatment with activin A to direct cell fate toward definitive endoderm, followed by the regulation of Wnt, TGF‐β, Shh, retinoic acid, BMP4, and FGF signaling pathways.