concept

silymarin

Facts (32)

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Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us Journal of Food Science & Nutrition 30 facts

claimSilymarin inhibits Mayaro virus (MAYV) replication and attenuates MAYV-induced oxidative stress, according to Camini et al. [96].

claimSilymarin and its fractions inhibit the HCV 3a core gene, according to a 2011 study by Ashfaq UA et al.

claimSilymarin exerts antioxidative and anti-inflammatory effects in wound healing, according to Samanta et al. [103].

claimSilymarin inhibits the expression of the HCV core gene in the 3a genotype and blocks viral entry and transmission of the Hepatitis C virus, according to Ashfaq et al. [94].

claimSilymarin enriched extract from Silybum marianum has an additive effect on Doxorubicin-mediated cytotoxicity in PC-3 prostate cancer cells, according to a 2019 study by Gioti K et al.

claimThe European Pharmacopoeia lists Silybum marianum dry extracts with a nominal silymarin content of 30 to 65%.

claimSilibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells, according to a 2013 study by Cufi S et al.

claimSilymarin interacts with heme in Plasmodium falciparum, according to Mina et al. (reference 89).

referenceSilymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by utilizing the nucleotide excision repair mechanism, as reported by Katiyar, Mantena, and Meeran in 2011.

claimSilymarin treatment reduces granuloma and hepatic fibrosis in experimental schistosomiasis, as demonstrated in a 2010 study by Mata-Santos HA et al.

claimSilymarin exhibits antiviral activity against the Mayaro virus and provides a protective effect against virus-induced oxidative stress, according to a 2018 study by Camini FC et al.

referenceSilymarin, a flavonoid derived from milk thistle (Silybum marianum), inhibits UV-induced oxidative stress in mouse skin by targeting infiltrating CD11b+ cells, according to a 2008 study by Katiyar, Meleth, and Sharma.

claimSilymarin, a chemical compound found in Silybum Marianum seeds, exhibits hepatoprotective, anti-inflammatory, and antioxidant effects.

claimSilymarin inhibits growth and induces apoptosis in AGS human gastric cancer cells by modulating the MAPK signalling pathway, as reported by Kim SH et al. in 2019.

claimSilymarin targets infiltrating CD11b+ cells in mouse skin and prevents UV radiation-induced damage, according to Li et al. [106].

measurementSilymarin, a standardized extract from Silybum marianum seeds, is composed of 40-65% silybin, 20-45% silychristin, and 10-20% isosilybin, and constitutes 70-80% of the plant's hydro-alcoholic extract.

claimSilymarin partially reduces UV-induced apoptosis by activating the Akt, SIRT1, and MAPK pathways, according to Cheon [109].

claimSilymarin prevents apoptosis partially through inhibition of the caspase-8 pathway, according to Rajnochova Svobodova et al. [108].

claimSilymarin induces cytotoxicity in prostate cancer cells, according to Gioti et al. [98].

measurementSilymarin is a chemical compound found in Silybum marianum with the molecular formula C25H22O10 and a molecular weight of 482.4.

claimSilymarin, silybin, and 2,3-dehydrosilybin reduce immunosuppression and oxidative stress in mouse skin, according to Katiyar et al. [107].

claimSilymarin exerts antibacterial, antiadherence, and antibiofilm effects against MRSA 43300, according to Evren et al. (reference 92).

measurementThe European Pharmacopoeia and the United States National Formulary state that mature fruits of Silybum marianum yield no less than 1.5-2% silymarin.

claimSilymarin inhibits gastric cancer growth and apoptosis through modulation of the MAPK signaling pathway, according to Kim et al. [97].

claimSilymarin destabilizes mature biofilms, inhibits the secretion of hydrolases, and mediates the destruction of the membrane in Candida albicans, according to Yun et al. (reference 88).

referenceTopical silymarin administration is effective for the prevention of acute radiodermatitis in breast cancer patients, according to a 2019 randomized, double-blind, placebo-controlled clinical trial by Karbasforooshan et al.

claimSilymarin exhibits antibacterial and antiadherent activities and affects biofilm viability in vitro, according to a 2015 study by Evren E and Yurtcu E.

claimSilymarin reduces the granulomatous periovular reaction in the liver and decreases hepatic fibrosis in mice infected with Schistosoma mansoni, according to Mata-Santos et al. (reference 91).

referenceSilymarin protects against UV-induced A375-S2 cell apoptosis through the roles of Akt and MAPK family members, according to a 2006 study by Li et al.

claimSilymarin, a polyphenolic flavonoid, impedes the growth of Plasmodium falciparum by interacting with heme, as reported by Mina PR et al. in 2020.

Medicinal plants and human health: a comprehensive review of ... link.springer.com Springer Nov 5, 2025 1 fact

referenceSilymarin, a compound found in milk thistle (Silybum marianum), exerts specific biological effects in laboratory animals, as reviewed by Khazaei et al. (2022).

Wild edible plants for food security, dietary diversity, and nutraceuticals frontiersin.org Frontiers Nov 27, 2025 1 fact

referenceSilybum marianum (fruits, leaves, and seeds) is used as a galactagogue agent, with hepatoprotectant, anti-haemorrhagic, anti-viral, and anti-cancer bioactivity, containing silymarin and taxifolin, as reported by Porwal et al. (2019).